Conserved Protein Domain Family
RNA_polI_A34

?
pfam08208: RNA_polI_A34 
DNA-directed RNA polymerase I subunit RPA34.5
This is a family of proteins conserved from yeasts to human. Subunit A34.5 of RNA polymerase I is a non-essential subunit which is thought to help Pol I overcome topological constraints imposed on ribosomal DNA during the process of transcription.
Statistics
?
PSSM-Id: 311912
View PSSM: pfam08208
Aligned: 76 rows
Threshold Bit Score: 65.8442
Threshold Setting Gi: 74625889
Created: 21-Jul-2016
Updated: 4-Aug-2016
Structure
?
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74615533  348 SEGKQIWYFTAPASIPIEVIQehAL--PLSKIQSGE-----PI-ITHNGAEYNATLE--E----------G-TT------ 400
gi 74625889   70 kKESNVFLVRLPPGMSADQIS--QL--KVGSKPTVE-----LK--QENENTYQIREEs---------------------- 116
gi 74857228   27 iDGKELWLIKIPRDLPYESLPn-KI--QVSDLNKVN-----VKsIDINKKKFTIHQDd-------------tEQ------ 79
gi 169866573  76 DDDVEIWVIRAPSAVKPKHLSslQIdpPSSSKTLKV-----GT-LKKKHAAFDIWSI--GkeitdetpvgG-EE------ 140
gi 302693354  69 DPDNEVWLIRIPEGVKPKHLEgaVM--SASSLSKSSrtskvGS-LWRKHTTYDIWSL--A----------E-TDdaenad 132
gi 470236734  31 qSKDQLWLMKLPKNFDINDLNglQF--TSSINNIKS-----DG-TSIGDSKYTITQE--K----------NiEE------ 84
gi 170094470  80 SDDVDLWLIRVPESVKPKYLEnlQVevPSSSKSTRI-----GT-VKRKHATFDIWSIgg------------dDDdl---- 137
gi 156403937 107 NKKKEIWLIKVPFNFDRRSLSgeTF--VLNG-SQDL-----LV-TQANTKKYEISSRalK----------S-HD------ 160
gi 512897957 346 tSDDEIFLIKCPSIIDLAAFKgvKI--NLDK----K-----CK-IKINNQTYECNWD---------------EG------ 392
gi 748495003 179 lgGKQIFLFTAPSKFKFSDVK--KI--KLHSGLDGE-----TI--ESDDVKFTIRRSmd--------------------- 226
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74615533  401 --------LHSIQV-----LLPTESGDK-YELMK-QPIAQALHIKRVTRLNPAAAATAAvs---apA--------TGNA- 453
gi 74625889  117 --------TSSVRV-----FLPDEQG-S-YTSN---EIKTGYVITETPKISQNIDTGITi------P--------TQAP- 163
gi 74857228   80 --------IQGLFN-----VWSKNSNNG-KMGLG-KPFTKFIQIDESVNLPKEQ------------V--------EPKPl 124
gi 169866573 141 --------INTLSC-----LLPRSKKGK-VYHAP-KPIARRLVLSAQPVSPTQAEPQTL-------PdrdpstqkYKNP- 197
gi 302693354 133 peeaastpVGGEELralscLLPRRKRKGdLYLAP-KPIARHLVLSAREVQPTAPQSAI--------P--------LQNP- 194
gi 470236734  85 --------IQSLVN-----VWYEKGSQG-EMKIG-IPFSKYITVEETIDIPETTATL---------E--------PTKK- 131
gi 170094470 138 -------pIGGEEIksiscLLPKKGKKG-KLYPApKPFARHLVIAAQAVVPSPIAPSESgpdpetgK--------YKSV- 200
gi 156403937 161 --------QSSCKV-----LLPSTENKS-VWSA--RPVNGHMTVIQSRHVPIADi----------aP--------CPPP- 205
gi 512897957 393 --------KNKIAV-----LSRNKNKTV-IKGLP---VNGMLCLRKRIPKLHIREENYM-------I--------NNQN- 439
gi 748495003 227 ------svSSSMKV-----MIPKQGKKG-YQLAS-VAPTVQYLITEAPPSGRTKIGEQ--------G--------LPPP- 276
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74615533  454 PRPQ-PAG--LKARFHPIGASPa----VPMGKIGADAVG-EAADSDVDM---------AEAAPAKSSKKRKNETAS---- 512
gi 74625889  164 LVPQ-RKN--LRQHFRPIGDAV-----GPESEp-------------------------EAEPKSGIKEHILQETGD---- 206
gi 74857228  125 PKPKqQHDl-LKGRYDPPGSS------GFLEKLGKESKNkNIKINKPTKp--------TTTTKTTTTTTTTSKTAE---- 185
gi 169866573 198 PRPS-YPNelLKHAFKPYGSN----------TTTVNGDTrEEEDGSMDVd--------VNAQTPSTKPSTKTDAKP---- 254
gi 302693354 195 PRQS-YPEemLTHKFMPYGS-----------LVATGDDEdV------------------AMDEPSAEEPAPASVDE---- 240
gi 470236734 132 TIQD-LSE--LKGAFRPPGGKY-----QLNNTIPQDVLEkMNKKKKKSTs--------TSTTSTKKQQPKQQVEEE---- 191
gi 170094470 201 PRQRyPTEl-LKHRFMPYGSVG-----GVDESv-------------------------VGPANAGDVAMDVDVKEV---- 245
gi 156403937 206 TKHK-VPD--IRCRWKPFGSGD-----------PDDSADrLQENHVPTPp--------LAYTPVRSLKEEQNLRESlqas 263
gi 512897957 440 NFIP-LLD--TKCRHPLFGANY-----KKAIKIPFSVAErLREVDQPQDidivdieseKTKKKKKKKDKIKIETSYvekd 511
gi 748495003 277 PRKQ-PEG--LKMRFMPAGYGEesdysINEAVLPRRDLVaNGDHDVVMDe--------AEPVIATPKKSKGNKDQV---- 341
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 74615533  513 -------EDAPSKKTKKTKEPKEPKe----------------------tKTSKKAKSE 541
gi 74625889  207 -------ATVEELQNKGKEKQKELKkgkrek------------kdeeekPKKKKQKKS 245
gi 74857228  186 -------KENKKENKKEKENKKEVKkqesesesese---dkkksskndkKSSKKDKKS 233
gi 169866573 255 -------DPEPKKSKDKEKKGKKRKvasdettveedaapkkkskksksss-------- 297
gi 302693354 241 -------GSHKKKEKKHKKETKGSKaedakaqkrksedddapkkskkkkva------- 284
gi 470236734 192 -------EKSSKKKKSSKKDDKEKKsskkkeesdeemkevaseeeestkKSNKKDKKK 242
gi 170094470 246 -------ASQKKEKKVNDKKKDEAVeekdtr------------kspvveTKKSKGKKR 284
gi 156403937 264 veeslesHEQEKKAKKKNKQPKIKHepespkqnsmsmsittpvnlkqecPTDYQSSKK 321
gi 512897957 512 neqtnaeELPPKKKSKKHKHTKETEk-----------------------VKSKKTKQK 546
gi 748495003 342 -------AETPKEKKSKKSKTVEEVvviee--------------daseeEIETKKSKK 378
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap