3QM0,3BIY


Conserved Protein Domain Family
HAT_KAT11

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pfam08214: HAT_KAT11 
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Histone acetylation protein
Histone acetylation is required in many cellular processes including transcription, DNA repair, and chromatin assembly. This family contains the fungal KAT11 protein (previously known as RTT109) which is required for H3K56 acetylation. Loss of KAT11 results in the loss of H3K56 acetylation, both on bulk histone and on chromatin. KAT11 and H3K56 acetylation appear to correlate with actively transcribed genes and associate with the elongating form of Pol II in yeast. This family also incorporates the p300/CBP histone acetyltransferase domain which has different catalytic properties and cofactor regulation to KAT11.
Statistics
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PSSM-Id: 311917
View PSSM: pfam08214
Aligned: 27 rows
Threshold Bit Score: 300.881
Threshold Setting Gi: 74626348
Created: 22-Jul-2016
Updated: 4-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3QM0_A          5 LNDFLSSV--LPVSeQFEYLSLQSIPLETHAVVTPNkDdk----rVPKSTIKtQHFFSLFHQG---KVFFSLEVYVYVTl 75
gi 74610660     2 LQAILKEV--LPQDsSFEILHLQSPPSE-SAPLVNntsk---qnrAT--TIKtEHLFCLAYKG---RIFYGLELYVYITc 70
gi 82260377  1327 VNDFLKRQs-NPESgDVTIRVVHVSDKVVEVKPGMKsRfvdsgemSESFPYRtKALFAFEDIDgvdVCFFGMHVQEYGSd 1405
gi 121993248 1693 VNNFLKKK--EAGAgEVHIRVVSSSEKCVEVKPGMRrRfveggdmMNEFPYRaKALFAFEEVDgidVCFFGMHVQEYGSe 1770
gi 74817089  1239 VNNFLRKK--DSGAgEVTIRVLSSYDKMTEVKPLMKkRfgn--dmEDSYPYRaKAMFAFEEIDgvdVCFFGMHVQEYGSs 1314
gi 122003274  952 VNDFLKKK--EVGTgEVTIRVLASSDKVVEVKPLMRaRftesgelSESFPYRlKAVFAFQEIDgqdVCFFGLYVQEYGSe 1029
gi 121961659  493 VNSYLKRHdtNNEAgYIHIRSVYSGEKTVEVKPGMKsKfvdskemPETFPYKaKAFFAFEEIDgvdICFFGVHVQEYGSd 572
gi 156383389  924 VNTFLQKQg---cPaEVTIRVVSSVQKQAEIKPGMKtRyegsgqlPEYFPYQaKALFAFEEIDgtdVCFFGMHVQEYGSd 1000
gi 6323027      3 LNDFLSSV--LPVSeQFEYLSLQSIPLE-THAVVTPnKdd---krVPKSTIKtQHFFSLFHQG---KVFFSLEVYVYVTl 73
gi 156844745    3 INSYLKDA--LPENeNFELLHILSVPKE-THPIVTQnIstr--rdSKNVTIKtQHFFSLFYHS---KVIFGLEVYVYITl 74
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3QM0_A         76 w--------deAdAERLIFVSKADTNGYCNT-RVSVRDITKIILEFILSIDPNYYLQKV--------------------- 125
gi 74610660    71 nhd----neveK-TERLVFVSKADTNGYCDI-RVNIKLVTLQLIRYVLSINPDYYLHRVipkerdykksgrtnlitkatn 144
gi 82260377  1406 c--------pqP-NQRRVYISYLDSVHFFKPrCLRTAVYHEILIGYLEYVKKLGYTTGH--------------------- 1455
gi 121993248 1771 c--------paP-NTRRVYIAYLDSVHFFRPrQYRTAVYHEILLGYMDYVKQLGYTMAH--------------------- 1820
gi 74817089  1315 c--------pgP-NTRRVYISYLDSVHFFKPrHLRTAVYHEILIGYLEYAKTLGYTTAH--------------------- 1364
gi 122003274 1030 s--------pqP-NRRRVYVAYLDSVFFFRPkQYRTDVYHEILVGYLLYAKRCGYAMAH--------------------- 1079
gi 121961659  573 a--------piP-NQRRVYLSYLDSVHFFRPrHLRTAVYHEILIGYFEYCKNLGYEFAH--------------------- 622
gi 156383389 1001 c--------qqP-NTRRVYVSYLDSVHFFQPrQLRTAVYHEILIGYLEHVGQIGFQMAH--------------------- 1050
gi 6323027     74 wd-------eaD-AERLIFVSKADTNGYCNT-RVSVRDITKIILEFILSIDPNYYLQKVkpairsykkispelisaastp 144
gi 156844745   75 ynstidshpklD-AERLIFISKADTSGYSDI-RVNVKDITNSILSYLLSIDPNFYLKNVkpiqrkrdiytkqlilgstst 152
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3QM0_A        126 -------------------------------------------KpairstcpreiltkICLFTRPASQYLF---PDSSKN 159
gi 74610660   145 srkalkila-----drlqnhnliepeifnafytkfhsgkelvtK--------------IALFTRPADQYLF---PNSSKN 202
gi 82260377  1456 -------------------------------------------I--------------WACPPSEGDDYIFhchPADQKI 1478
gi 121993248 1821 -------------------------------------------I--------------WACPPSEGDDYIFhchPTDQKI 1843
gi 74817089  1365 -------------------------------------------I--------------WACPPSEGDDYIFhchPPEQKI 1387
gi 122003274 1080 -------------------------------------------I--------------WACPPGEGDDYIFhmhPTEQKI 1102
gi 121961659  623 -------------------------------------------I--------------WACPPSEGDDYVFhchPPEQKI 645
gi 156383389 1051 -------------------------------------------I--------------WACPPSEGDDYIFhchPPEQKI 1073
gi 6323027    145 artlrilarrlkqsgstvlkeiesprfqqdlylsftcpreiltK--------------ICLFTRPASQYLF---PDSSKN 207
gi 156844745  153 rkglkilsn-----rrrkgfrldnekinknlfshftcnqniitK--------------ITLFTRPSEQYLF---SKSSES 210
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3QM0_A        160 SKKHILNGEELMKWWGFILDRLLiec-fqNdT-QAKLRIPGEDpaRVRSYLRGMKyplWQVGDIFTSKEnslAVYNIPLF 237
gi 74610660   203 PNKHNLDGDGLLKWWASLLDNLLvsdfnlN-KtKAKIRIPGEDkyRFRRYTNALKcgiWTHGDIFSDNDsdsVIKCIPMF 281
gi 82260377  1479 PK-----PKRLQEWYKKMLDKAV----------SERIVHDYKDifKQ-----ATEdr-------------ltSAKELPYF 1525
gi 121993248 1844 PK-----PKRLQEWYKKMLDKGM----------IERIIQDYKDilKQ-----AMEdk-------------lgSAAELPYF 1890
gi 74817089  1388 PK-----PKRLQEWYKKMLDKAI----------IDRVVVDYKDifKD-----AIDsg-------------isSAKDLAYF 1434
gi 122003274 1103 PK-----AKRLQEWYRRMLQKAI----------IEGIVVDYKNilKD-----ALDhq-------------lvSPTEIPYF 1149
gi 121961659  646 PK-----PKRLQEWYKKMLDKAI----------VDQVVLEYKDiyKQ-----AKDdr-------------lqAARELPYF 692
gi 156383389 1074 PK-----HKRLVDWYKKMLDKAI----------MDKVVIEYKDilKQ-----ASDdg-------------ltNPKELPYF 1120
gi 6323027    208 SKKHILNGEELMKWWGFILDRLLiec-fqN-DtQAKLRIPGEDpaRVRSYLRGMKyplWQVGDIFTSKEnslAVYNIPLF 285
gi 156844745  211 GNKHILAGSTLLKWWISLIDKNIlhnfkqD-T-KAAMQIPGESslEIKRYFKSLLypnWQVGDIFGGTDtslAVYKIPLF 288
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3QM0_A        238 PDDPXARFIHQLAEEdrlLKVSLSSFWIELQERQEFKLSVTSSVMGISGYSLatpslfPSSADVIVPk------sRKQFR 311
gi 74610660   282 PDDPKSRFMKQLFEEnriQTTSLDTFWTELQERQEFKLSVVVSVMGISGIYEidt-nyKPSTDVYRCr------sKRQFH 354
gi 82260377  1526 EGDFWPNVLEESIKE-------LEQEEEERKREENSTCSESIDD---------------------TKsdsknakkKNNKK 1577
gi 121993248 1891 EGDFWPNVLEESIKE-------LDQEEEEKRKQAEAAEAAAAANLFS-----------IEDNEVSGDgkk--kgqKKAKK 1950
gi 74817089  1435 EGDFWPNVIEESIKE-------LDQEEEEKRRREEAEAAAAEAEAQDTVEETtd---aVCSDV--AGtkkgekkgQRNKK 1502
gi 122003274 1150 EGDFWPNTLEDILKE-------LEEEEAR-RRREEAMAQAEAEDDEADCSSStneglpGDPDK--RSgkkkakkrKGNKK 1219
gi 121961659  693 EGDFWPNVLEESIKE-------LEQEEED-RKQAEANEQAAAEEV--G-------------SW--APqtrrtiknRRQRK 747
gi 156383389 1121 DGDFWPNALEDSIRE-------LDQEEEE-RKANAAAAEASGKEG---------------------SkvkgnskrSNSKK 1171
gi 6323027    286 PDDPKARFIHQLAEEdrlLKVSLSSFWIELQERQEFKLSVTSSVMGISGYSLatpslfPSSADVIVPk------sRKQFR 359
gi 156844745  289 PDDPKSRFIRQLVEEgriLSVKLSTFWTELQERQEFRLSETVSVIGIEGYLSklpiyiPGTDDIIISg------sKNKFN 362
                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*....
3QM0_A        312 AIKKYIT-GEEYDTEEGAIEAF-TNIRDFlllrmATN---LQSLTGKREHRERNQPVPA 365
gi 74610660   355 CIKNYIT-GEEYDTEEGALESY-QNVNDYls-reGTS---LLTVTGNADYSKFKQNRTT 407
gi 82260377  1578 TSKNKSSlSRANKKKPGMPNVS-NDLSQKlyatmEKHkevFFVIRLIAGPMANALPPIV 1635
gi 121993248 1951 SNKSKAA-QRKNSKKSNEHQSG-NDLSAKiyatmEKHkevFFVIRLHSAQSAASLAPIQ 2007
gi 74817089  1503 ANKSKGS-ARKNNRKTNLPQGT-NDLTAKlynhmEKHkevFFVIRLHNQQIAASLPPIT 1559
gi 122003274 1220 GNTSTAS-KRKRLDGPIDGA---EELSRKvydtmEKLkeiFFVIRLHRHNSAASLPPTT 1274
gi 121961659  748 QPQRKLS-QRSAKKK--IPQVA-NDLTDKlyqimEKHkevFFVIRLQAADTISKLGSIA 802
gi 156383389 1172 GTKSKAG-SRKLSKKINGPSMElCDLSQRlystmEKHrevFFVIRLNGRKT----PDTS 1225
gi 6323027    360 AIKKYIT-GEEYDTEEGAIEAF-TNIRDFlllrmATN---LQSLTGKREHRERNQPVPA 413
gi 156844745  363 RIKSYIT-GEEYDTEEGATESY-YNVKTYlkeriGTN---LILISGSKKNSLSTRTEQS 416
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