4MFV


Conserved Protein Domain Family
CTNNBL

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pfam08216: CTNNBL 
Click on image for an interactive view with Cn3D
Catenin-beta-like, Arm-motif containing nuclear
CTNNBL is a family of eukaryotic nuclear proteins of the catenin-beta-like 1 type that contain an armadillo motif. A human nuclear protein with this domain is thought to have a role in apoptosis. The interaction of CTNNBL1 with its known partners (the Prp19-CDC5L complex and AID) is mediated by recognition of NLS (nuclear localization signal) motifs. The RNA-splicing factor Prp31 is also an interactor, with recognition also occurring through the NLS. CTNNBL1 uses its central armadillo (ARM) domain to bind NLS-containing partners.
Statistics
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PSSM-Id: 336960
View PSSM: pfam08216
Aligned: 104 rows
Threshold Bit Score: 90.6568
Threshold Setting Gi: 927381079
Created: 28-Mar-2017
Updated: 23-May-2017
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4MFV_A         28 KRLLQIIDRDgeeeEEeeePL---DESSVKKMILTFEKRSYKNQELRIKFPDNPEKFMESELDLNDIIQEMH----VVAT 100
gi 74878244     9 IDIDEILKQAe--nVE---CV---DEDSIKKLATVLKKKKNINERDRIEHPDKPEKWVASEVDLDEILVNIK----NLSV 76
gi 74863160    12 VDVEEILKQAe--nIE---CV---DENSIKKIGVLLKKKKTKNERDRMEYPEEPEKWVSSEVDLDEILVNLK----NLSV 79
gi 74961630    43 EDILAALEADqs-nYV---AL---DDVQVKKLVIQLDKKMRLNREQRVKNPDDAQKFMESEIELDKAIQEMH----SLAS 111
gi 1158590946  36 EDILAALERDes-qTV---VV---DEAAVKRIVMQLEKRCLRNREMRIKYGDEPAKFMDSEIELNEAIQEMH----ALAT 104
gi 541043540   37 ADILAALEKDts-rAE---VV---DEIVVKRTVLQLEKRCLRNREMRIKYGDDPTRFMDSEVDLNFAIQEMH----ILAT 105
gi 313230842   68 QELLAKAE-IdngeQE---DM---DEAATRKLFLLFDKRMKKNQDQRIKYAQKPEKYMNSEMDLYAHLHEIK----QLAT 136
gi 294867331   20 dDIQELIKKNeqteVK---SL---DVEGCAALVRKVASLVKENQRLRIKHSDDPTKFLESEVSLAEEIRRLT----ELAV 89
gi 672277166   54 ETVKKILDQAdemhVE---VL---TEANLRRAVAQLERRIKKNQQDRIRHAEDPEKWIKSEVDLDEEIKRWK----QLAA 123
gi 927381079   29 ERVLEFLKRDtvvePQ---KIveyNVQWVKNSLTKLGELVTSNLQMREKHSSDPTKVMDSEFELFQGLKVWSeisiALAE 105
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
4MFV_A        101 MP-DL---YHLL----VELN-AVQSLLGLL-GHDNTDVSIAVV 133
gi 74878244    77 CT-NL---YKSM----IESD-IFGDIINLL-NHPNNDIVIEVI 109
gi 74863160    80 CT-NL---YKSM----IDSD-IFGEIIDLL-NHPNNDIVIEVI 112
gi 74961630   112 QP-DL---YGSF----VEVN-GVEILLQLL-GHENTDIVCATL 144
gi 1158590946 105 QP-DL---YELL----IDIG-ATTTLLQLL-AHENSDVVAAVI 137
gi 541043540  106 QP-EL---YDIL----VDLN-AASTLLQLL-AHENSDIIAATV 138
gi 313230842  137 QP-HL---YPLFwdedINSGlTLVNLISLS-SHENSDIAAmar 174
gi 294867331   90 NPaEL---YPAF----VAGH-GGRVLVGLL-QHANVDICAEAL 123
gi 672277166  124 DP-AL---YPLF----IEAR-GLELLLSLL-NHSNQDIQLEVI 156
gi 927381079  106 AP-DYqqcYTVL----VASP-VFAEVVGLLaSHPNIDVREQVL 142
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