Conserved Protein Domain Family
SHR3_chaperone

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pfam08229: SHR3_chaperone 
ER membrane protein SH3
This family of proteins are membrane localized chaperones that are required for correct plasma membrane localization of amino acid permeases (AAPs). SH3 prevents AAPs proteins from aggregating and assists in their correct folding. In the absence of SH3, AAPs are retained in the ER.
Statistics
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PSSM-Id: 336964
View PSSM: pfam08229
Aligned: 50 rows
Threshold Bit Score: 164.678
Threshold Setting Gi: 1023179620
Created: 26-Mar-2017
Updated: 23-May-2017
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74601587    5 DIVPVGSGLIIGATSFGLGVLYANLPYDVNTLWRQD-ETGt-AFITSLAHYSVWGNSPAYVHHIFHSVIGLGFIGAFIKL 82
gi 15214297   14 GLKVAARYGVLMSTSFIFALLFHSSVADVNTLW-SP-GPEs-AFDAAETYYTLVAGSHFIVKYTVYTIMGLNMIFHLIQA 90
gi 748500564   3 GAASFWTYLIVCPTSFILGILFTNWSYDFPLLWTSKrLTPe-MIKAIEAHYVMLYDSPPLIGRVLHAIILIALAAFIAKL 81
gi 443924426  55 htmgFRHAAVLSSVSFFLGILFICFNVDHKVLYAAP-LTDk-IVDDGFEFYTTFYNAPRAVKGLLHAMMGLGILSLVAKL 132
gi 599399020   1 --mgfrqAAVLSSVCFFLGVLFICMNVDYRVLF-TP-LTEd-VVRDGLEFYTTFFHSPPAIKALMHAIMGVGIIGLVGKL 75
gi 511011242   5 ymqtakVALILCSCFFSYGTYWSDWAFDYYLLWANP-SEYpeAITRATFYYANQGHIPNILKYVPIANLCIAAAGFVTGL 83
gi 597967463   1 --mgarAGIVVCITSFLLGALFTHWIADSLTLWKSP-VTDe-HLWTAASYYSIVTKGPREILYLLFALVILGGSTILWSF 76
gi 636762417  20 DSSSFATYMIIAPTCFFLGMLFSSFPYDFPLLWTSD-VTPdaYYDQLETHLKFIHASPPIIPRILHMAISIGFIGFFIKL 98
gi 154290726  20 GASSFATFMIIGPVCFFLGILFSSFPYDYPLLWTTE-STPdaYYNFIEEHLKFMHASPPIIPRILHIVVSVGFIGLFIKL 98
gi 528298506  20 sASSFATYMIICPVCFFLGILFSSLPYDYPLLWTSE-ATPhaYYDQLETHLKFLHASPPLISRMLHIFITIGFSGFFIKL 98
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74601587   83 YKPSEDAKYFEYGSLFLYMVGVIIYLTNLRIGVNSCLAGDWGE---------VDMPTG----INVMAASQVMIGFALFGV 149
gi 15214297   91 TGAKGDDKLFFYSSTLLYLTALILFIVNVAPSMLVVKLQNYVQ---------FPRNMH----LSVLAASHVLVEFLLAGV 157
gi 748500564  82 YKPSESNALFDGASLVLFMVAVIVYGSNTIKGMQIIKGGDYGEd--------IPQAQS----LQVVAASNTIMALVLIGV 149
gi 443924426 133 HKWDESALFFDGSSLAAFMFGIILYASVVIPALRIIVSPLETDg-------rKERTES----LRILAAANTLIVICLVGV 201
gi 599399020  76 VRMDEGAKWFDGSSLAAYIFALSVYLSVGLPASRTIATPVEG----------VDTREDqieaLRLLSAGNTIVIALLGGV 145
gi 511011242  84 LTMTDGNLLFDGASLVLMMFGITTYLSSVKPAITVVSESADVN----------EITTS----LKNIAAAHFIIVLAITGI 149
gi 597967463  77 GDGQAGNLMFDGGSIFLFGMTAVMYVYAVLPNLLTHFENLPPHglkd--pfpRTLRQS----TLDLASNNLICSVALTGV 150
gi 636762417  99 FKPSEANLLFDGASMVLYLIGVVVYITNIVKGLRIVTLGKYEAppgt-tepaIGREDS----LRVMAASNTILALVLVGV 173
gi 154290726  99 FKPSEANLLFDGASLVLYVVGVVVYITNIVKGMRIVTLGLYGEagapegeagVGREDS----LRVLAASNTILALVLVGV 174
gi 528298506  99 FKPSEANLLFDGASLVLYVIGVVVYISNIVKGLRIVTSGNYGLkegn-teiaIGREES----LKVLAASNTILALVLIGV 173
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 74601587  150 LLLQGGL---YYAEW-YDNRLKVkFFEEEERA--A-LAAASAKTDN 188
gi 15214297  158 ILIQLGYvfgYHVQSiQQREYAEdMREQELAE--KaKLESESATTQ 201
gi 748500564 150 LLLQAGQ---WYAERkEKEELDA-MSEglnnadsptvskkelkekk 191
gi 443924426 202 LAMQGGQ---EYARRyEERELRR-VQEQERKE--AaAGKDGAPVAS 241
gi 599399020 146 LFLQAGE---EYARRtEAKELAR-LAELDKKD--RsATATSAAGEN 185
gi 511011242 150 IGLQITH---YFVMKrSNKDREDgGNQETDQE--EdEEDEEEEQEQ 190
gi 597967463 151 LALQAGR---FWAETpDSDDEEFvLVEAPSAE--EqQQQQQQRQQE 191
gi 636762417 174 IVLQVGQ---WYAERkEQDEIES-FEGKQAEK--TaKKAEKGNTHV 213
gi 154290726 175 LVLQAGQ---WYAERkDQDEAEK-FEKEEQEKkeSeKKQRSGSGHV 216
gi 528298506 174 LVLQAGQ---WYAERkELDEVAQ-FEAAEKTT--FaKSSRSMSVPH 213
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