Conserved Protein Domain Family
dCache_2

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pfam08269: dCache_2 
Cache domain
Double Cache domain 2 (dCache_2) may be a result of single Cache domain 2 (sCache_2) duplication.
Statistics
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PSSM-Id: 336977
View PSSM: pfam08269
Aligned: 42 rows
Threshold Bit Score: 86.2471
Threshold Setting Gi: 81653341
Created: 27-Mar-2017
Updated: 23-May-2017
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81642054   36 YQAYKESIDNIINN-YNNQYQSRVREEVNSATDYIH----YSLQEELAQAEEDIRKRGQVAY------------TVASHI 98
gi 123739908  41 HRDVGRAMLHAEES-SAQNVLKLVELNIKAGYDQLT----GDKIEILSNLQSDLQSVSEIAQ------------SSFKVY 103
gi 81653341   67 APKMKEEQFKTETH-TIERLLSKMEHQVRLAIKVNQfhssSQKTNNDLRLQNHLQNLHLHALshpsasleqwiaTLDQEF 145
gi 506333828  29 QRTVTESVMESEFA-HAQAIVDAVYQEVNNQYQSIV----FSEKYAIASRKEQLQNIVGISI------------DLIHLN 91
gi 505935463  39 fafilhftftqlNA-TIEEGMEAAGSSIVDMIEL----------TVNSSIQSYLRAIAEKNL------------EIIKNY 95
gi 503279210  38 HETVMTNIER-----QLDASTEALRAMVQSA--------------TDASVRNRLRAIAEKNR------------DILVGL 86
gi 503018974  41 SADYLQT--------QMKSSTRTLHNLIGSL--------------LRNSVRSYLRSKVEVGV------------DIVKEA 86
gi 505940724  27 gyLIASALTHREEA-RAQADMTVVRQLAETATQTVF--------------THTLRTTAENIR------------LVCQTL 79
gi 501817738  37 igyISTQQAYLGITqTSKADLEHMASFTIDLLKSHHqqfqVYKQDKERSFNLELATLTNLAY------------NMVEAE 104
gi 506332755  29 SSTLEEDMAHFQGR-TARNTIRVGMLYLQEGHQALD----RYRKHAFQDRKQAVKDAMTLFL------------AQVGSF 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81642054   99 YSL------YK-N-EKDIAE--------LRKMVTEILRPIR-WNDGQGYYFAGRIDt--GTMDLFADE----PILEGKGS 155
gi 123739908 104 GDL------YK-SgRVSQEE--------AEAMAFKWLREVR---FGEVEVFVFNRQ---GGVMAHPEH-----SVEATYI 157
gi 81653341  146 QGEacrallIK-EnQILHSTk-------PLPSASPLLSSLTaLPQGEWHSY------------LHPRP-------QG--- 195
gi 506333828  92 YNK------YKqG-LISEAE--------AKRLSIEQLKNMR-YDDGTGYIWINDTTtpiPLMIMHATM----PDLDGKIL 151
gi 505935463  96 HQK------QLtG-ELSENM--------AKMAVTAILRSQ--QIGRSGYISILNSQ---GVFQFHPNS-----DLEGKPI 150
gi 503279210  87 EAE------VQ-AgRMTGQA--------ARTLARTILLSQS--IGQTGYVYCITSK---GVVAVHP-N----EQLLG--- 138
gi 503018974  87 LRE------QG-LaDLPEEEwpvslppeLEERLVNSLLSFH--VGESGYYYGIRSD---GTVFFHPDP-----KIAG--- 146
gi 505940724  80 FHQ------HQ-SgRLTLDE--------AQRLALEALAAQR--VGQQGTVLCIDSQ---GMLLRHPDTtrirTRLDAAVF 139
gi 501817738 105 HRQ------MK-SgHIDPAT--------AMLEARKALKKVN--VGETGYIYAMSSK---GDLQVHIAR-------EGDNV 157
gi 506332755  92 YEL------YK-AgELTEKE--------AKEAAFKLARNTR--YFNNDYFFIYTDK---LKALAHPDR-----SLEGRDL 146
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81642054  156 KEIISL----T-GVDIMGMAQEII-QKKGA---GLFSYDLLKPn--YPGRIYFKRAFVKYFPPFDWFIGAGVYRNDSSYL 224
gi 123739908 158 TSLRDF----K-GRVIYQTMADDNlDASGD----KAIFNWRKP---GSDRDSRHIGYFLPLPDWKMTLVAMVDFEYVEAE 225
gi 81653341  196 ----------------------------------------------ACPTSDKETLLFKPLGTTGYRVGVHCQSQDFISE 229
gi 506333828 152 DDPRFKgvraS-NENLFVTFREIG-TQFGS---GFVEYLWPKPtknGFSKEQPKLSYVELFKEWGWIVGSGVYIDDIEEE 226
gi 505935463 151 LKMETY----SpAWSFITEQI-----TKKT---GYMEYVWKNP---DEKTFRPKALYMVHFKPWDWIISVCCYREEFQSI 215
gi 503279210 139 ---QDL----S-GQWIGREQAKRL-T-------GYMEYEWANP---GEMRTRPKALYMVYFEPWDWIISASAYRQEFTSL 199
gi 503018974 147 ---SNQ----R-EREPVKEQLLLRn--------GYLEYRWRNS---DEEEPKNKALYMAYIPELDWILSATSYREEFVHI 207
gi 505940724 140 SRLQQL----Ta--------------------dGYLEH--------QPGGQPPTALYRAAFPPWGWTILATCELGERQRM 187
gi 501817738 158 YNEKDE----N-GRYFIREMCQRA-LKSRSgevLFIVYPWRNAi-lGDKAPRKKVVAYRYFKEWDWIIAAGGYLEETYGD 230
gi 506332755 147 SKGVDK----N-GYAYGPDMIRKAtREGG----GFVNLLWTRL---GENDPISKLLYVKGFPKWGWIIGTGAYVDDIEGA 214
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81642054  225 VQ-------DDAIK-QLQNMTFG-DGGEIFIFRFNG-------TIICSR--DEK-LLGRSITslkds------------- 272
gi 123739908 226 SRkkmsaiiDSLRK-TFPDIKVA-NTGYAYLFNGQS-------EILVPPpgndeegeap--------------------- 275
gi 81653341  230 RRafeseigVILKE-SFQSIKEG-NPGFAYMMWVDGsertcdhNATLRTslESE-ASLYNRVccvsetsptdqpltgdlk 306
gi 506333828 227 VNvrikavlQELRE-SFKKTKIG-KHGYIFLFSGKP-------ELVIHP--VYEsIPIAELLnpet-------------- 281
gi 505935463 216 ID-------FKVIEqRIAAFKYG-RSGYAIILNQQG-------EFLVHP--H--------LSdadkp------------- 257
gi 503279210 200 INv------EDFRA-GVASFRVG-DSGYAFILDGEG-------NMVFHP--WLKg----NMTdaida------------- 245
gi 503018974 208 IDl------AALRR-TINSVLIG-KGGYSYVIDRAG-------TFIAHPylygkdar----------------------- 249
gi 505940724 188 LP-------QILAA-GTPATALPvDGRQSFLLSPSG--------VFWPPlfpeaa------------------------- 226
gi 501817738 231 VNfek-rafAELKA-KIKAKQVG-KTGYIFCMDSKG-------NFTVHPggegrnfld---------------------- 278
gi 506332755 215 VEnqkqdliRDMRK-GFSQIRLA-ETGRLFIFDNNK-------NVLVPPlgagpdfa----------------------- 262
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81642054  273 ---------kqhlYGEELWrAGVEGAq-eGFVTYSGYRKGGD-----LPR---QKLSYVRAY--PELGWVIGASSYMEEM 332
gi 123739908 276 ---mslngeqqnlLAELIGqIAAQEQi--GQVMYHYLDPFVAsarhdEER---QVVAYVSYF--KPFDWYLSVVVPVEEI 345
gi 81653341  307 aadylrasttqepLRHWLDkEDDRGN---------------------LIH---PAITWARKFetPAYPLILAVTLYEEEI 362
gi 506333828 282 ---------gnplFLELKNaA--HVD---GIMEYLWDKPPRN-----KGEftfRKRAFIKYF--EPLDWYICSTAYMDDL 340
gi 505935463 258 --------rfaeqIQKIIArAGTGNT---RMVKYLWKNPGEQ-----DER---EKILFFRRI--PQFGLIIGVTTYTAEA 316
gi 503279210 246 --------agtelFQHIRRi----RD---GKIAYSWLDPGRD-----TPR---DKLMHFRSL--PELGWIVASSSYLDEV 300
gi 503018974 250 ------gympadeFSSILQrFYAEGE---GIASYYWRTPSGN-----KRR---LKIVNFKYI--PDFDWIVATAFYWDEI 310
gi 505940724 227 --------ptpeqRQALLSlAETMRRqqnGRIT--WTPPTAL-----QGE---EKTILFRHQ--PDNDLLAGVVVPSAAL 286
gi 501817738 279 ----akdsdgnefIREMCVnKT-------GWIRYPWKNAGDS-----VPR---MKIVRYEYF--QPWDWVVAVGSYEDEF 337
gi 506332755 263 ------ktlnlntGNSLMHdLKEVGKlgdWRLDYKVRRQDG------EIV---ERQSYVRYF--APLGWYVASTVPKQEI 325

                 .
gi 81642054  333 E 333
gi 123739908 346 S 346
gi 81653341  363 Y 363
gi 506333828 341 E 341
gi 505935463 317 Y 317
gi 503279210 301 Y 301
gi 503018974 311 G 311
gi 505940724 287 R 287
gi 501817738 338 Y 338
gi 506332755 326 F 326
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