1NF2,4DWO,4ZEW,3L7Y


Conserved Protein Domain Family
Hydrolase_3

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pfam08282: Hydrolase_3 
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haloacid dehalogenase-like hydrolase
This family contains haloacid dehalogenase-like hydrolase enzymes.
Statistics
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PSSM-Id: 311955
View PSSM: pfam08282
Aligned: 66 rows
Threshold Bit Score: 155.081
Threshold Setting Gi: 74862782
Created: 21-Jul-2016
Updated: 4-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1NF2_C        5 FVFDLDGTL-LN-----DNLE-IS-EKDRRNIEKLS---------RKCYVVFASGRMLVSTLNVEKkYFK--RT---FPT 62
gi 74861610   6 IALDLDGTI-LN-----SNKQ-VS-ENSKRVLQYISkpefknidgEEVLVLLASGRAPYLVSPVEE-ALG--ID---CYL 71
gi 81529844   6 IFFDIDGTLlVH-----NGKEsTIpYSTKEALKKLKe--------KGHNLFICSGRPIRFAIQEFQ-EMV-------DGY 64
gi 81767941   8 VFFDVDGTL-IDcgkglYKPS----NKTKEAIKKLKe--------NGYLTILATGRPMSFVDDGLK-ELE--LD----GY 67
gi 81532862  11 IISDIDGTI-LP-----YGWKrVS-DKTVESFQKLKe--------NNYYTALATGREYVTIGDVLD-QVG--HS---DFF 69
gi 81637281   3 FVFDLDGTI-CF-----DGKQ-IP-LNIQHALEQLMq--------KDHQLIFASARPIRDLLPLLNpKLQq------AML 60
gi 81747907 504 LVFDLDGTL-LN-----ENKR-VN-VETISAMQKAYq--------EGHELVIATGRSYQQTIDVVN-QVG--VV---RYA 561
gi 81767701   4 FVSDLDGTL-LN-----KDQV-IS-DYSKKELNRLIs--------TGVNFAIATARSPATVSDILD-GID--IK---TPV 61
gi 81420706   8 VISDLDGTL-IRy---eNNKHiVE-PAAIHAIEKLAs--------RDITFTIATGRKQSDVVNLIK-TYN--LSgmvRYI 71
gi 81437664   6 IALDIDGTV-LN-----HDGHtPS-EGIVAQLARLV---------REHYLVFASGRSTGDTLPVLE-SLGltQGampQFI 68
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1NF2_C       63 IAYNGAIVy---LPEEGVI-LNEKIP---PEVAKDIIEYIKPLN-VHWQAYI---DDVLYSEKD-------NEEIKSYAR 124
gi 74861610  72 IGYNGSICfgrkSEGRNTV-FSHSID---NSNLKAIFKYVEENN-LFLNIYG---DGIVYGIDKpe----lAEKPRRYSI 139
gi 81529844  65 ICCNGTYI----VYNGKCI-YNKLID---KDTLKYLIKEFCKLG-ISASFSG---AYNGYSYNM-------SSEKIHQMN 125
gi 81767941  68 IASNGTYI----ELNNEVI-LNDDIK---LEKLKEIMDYCVEHN-INFILEG---QKTSYVLNN---------DVAKKMV 126
gi 81532862  70 IGANGSFIy--dIKNKKEI-YSNYLN---FDNVKKFSKFFKANFnNDLMFVT---DDKWIHLSDin---hsHLDQSWFLA 137
gi 81637281  61 IGGNGAIT----QVNKQIT-AQQPIS---SVAFTQIKQWIEEFD-LDYL------ADDLWDYSK--------------RL 111
gi 81747907 562 VMNNGALIy--dKENNKIFrNTDPLP---KDLIKYFFEIVFSKN-IPFLLYS---DLNVYMYNFtnd-dkkVFLPYINER 631
gi 81767701  62 VLMNGVIIf--dIEKKKYI-DVKEID---KESVKEIIKILQEYN-KTFFLYGi-kDDYLWVYHKdftydfeREYYEERCN 133
gi 81420706  72 IACNGAVIy--dIEEEKII-QNSYLTkkvKTAVMKHVDAFKEMT-QDFLLFSydiNNNIYLYDPnkk-pneSLLKELTSY 146
gi 81437664  69 ICCNGAVTl--kMENNEYV-RHRVISfdaSRTLEYIINTLPG---VELAVER---CDGVYMHTS-------------NFP 126
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1NF2_C      125 HSNVDYRVEPNLSELVSKMGTTKLL-----LIDTPERLDEL--KEILSERFKDVV------KVFKSFPTYLE--IVPKNV 189
gi 74861610 140 MTGATYKLIPSYSTLPEDFTPAKCLi----ILDDDKECDQL--LETMRPLFPTLSlvksncMNKDYKQYYVE--FLEHGV 211
gi 81529844 126 RFYKTENPYILDNWNIEEIEANNVDv----FFKNNEHMEKC--IKYLEHK-----------LIFNTHKPYLSadVSFKNW 188
gi 81767941 127 ENFSLPEESFTGDWTEEELSANKLVi----VDNNKDDFKDI--FERFKDEFV---------FMQHPGHSSYD--MYRRGC 189
gi 81532862 138 NHKDKFKDIADKSINKEKISILTI------VSKDENVYNEC--KGFIEKNCPEI-------EINTKWSSGFF--VSSKGT 200
gi 81637281 112 RQPHSIEHKIDPAKLAQNRPLSAIQhpiktILLNLTQTQFLflKQQLTHLEVNLIe-----HSEENGRFNLD--ITAKHI 184
gi 81747907 632 TIDISGMSIDELFKYLNNNNIDLFNlcahcEALTEEDWVQM--FKYYKEDLKLC-------NLTSALKGSID--IYGASI 700
gi 81767701 134 KKLKSFKKVENYLDILDDNQIINFVffednKLIAHELFEKIlkVKGVTGNCYK--------DIYNEGAFFLD--VYNEEA 203
gi 81420706 147 EGSFSSNNYIYIDDLNERDDLIKLI-----FFYNRSSMTED--ITDYLAKFIKLTkid-tnDCVVVSPMSFE--LNSADC 216
gi 81437664 127 LDYLHDKRILSSVSEIVHTPPARVV-----VYEASIDASEI--AKRFESRC----------INFNNAWGYWD--IMPPGV 187
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
1NF2_C      190 DKGKALRFLRERMNWKKEEIVVFGDNENDLFMFEEA----GLRVAMENAIEKVKEASDIVTLTNND-SGVSYVL 258
gi 74861610 212 NKGTSVIDFCKAKSIDSSKVVAFGDAENDNEMLEQS----GLGICLANGTDITKSIANKVSQYTNDqDGVAREL 281
gi 81529844 189 DKSKGIEYLVKYMKRDMKDTMAFGDGKNDITMLKTV----NIGIAMGNAVDEVKNKADMVTDSAAD-DGIYNAL 257
gi 81767941 190 TKAHGIEHLIKELGLSDKDTYAFGDGENDIEMFQRV----KYGIAMGDAHETLIPHAYKQTENVPN-EGIYKAL 258
gi 81532862 201 NKLSAAKALSTHLNSSIDQVMAFGDSENDIEMIKGV----GHGIAVANALDSVKKVAKLVVGPANK-DGVFHYL 269
gi 81637281 185 NKYYTLTTYI-----GQAKYVAFGNDMNDIELLQHA----DYSVCVGDFAPLRKLANTHLFANPAD---IAQKI 246
gi 81747907 701 SKYIGYLKLKEMINCFDDDVYFFGDSNNDYDLMSHL----ENGVAMGNANPRLKAISKYVIGDNNS-TAIADFI 769
gi 81767701 204 SKANGIKFLA--DYVEHSKVITFGDGENDVPMFEIA----DECYALENASAGLKAIATGIIGNNND-DAVVRFL 270
gi 81420706 217 NKGNAVLELNKILKKDLAKTLSIGDSFNDIPMFKVT----GVSVTLESSHREVQNNATNVLDVKAS-DVVADAI 285
gi 81437664 188 NKSTGLSFVQQSLCVSGDMVVSAGDGFNDIEMLEWTksigGRSFAMGQAPARVKQAALKVIGTVYD-GGLAKEL 260
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