Conserved Protein Domain Family
tRNA_lig_CPD

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pfam08302: tRNA_lig_CPD 
Fungal tRNA ligase phosphodiesterase domain
This domain is found in fungal tRNA ligases and has cyclic phosphodiesterase activity. tRNA ligases are enzymes required for the splicing of precursor tRNA molecules containing introns.
Statistics
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PSSM-Id: 311968
View PSSM: pfam08302
Aligned: 77 rows
Threshold Bit Score: 151.617
Threshold Setting Gi: 758973671
Created: 22-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121919425 555 SRENLEVIISRMFETYPALFegKDMPTDTDMDEAIHWAMnDYT-PDFKMDLSRNggnGGNL---KGAQN------Nnark 624
gi 74692909  566 SLTNIRTILEELHASYPTLV--PELPSDSVIEESFKNTL-SYK-PTFTKIIKSS-------------------------- 615
gi 74605133  558 SLKNTITVLKELQRNYGDVI--PSIPDDSIVHQAFERAL-NYK-PTITKIIKGGnkiDKKQ---HK-------------- 616
gi 19924244  547 SLENARRIVNYFKKNIPELI--PNDPSDDDYAAALNYAVnEYV-PTYRKTFGND---SKKI---KNKIT------Aeg-- 609
gi 366988261 562 SLMNVKTILKRLHDVYPILI--PEIPSEESINIAFQKSLq-YK-PKMK------------E---RKVTN------Ne--- 613
gi 403214128 564 SLINTKIILENLHREYPILV--PEIPDENAIKSSFDLSL-EHK-IPIK---PGS---STPNtkeKKNKP------Ak--- 624
gi 410074281 564 SLINSMTIINELHEKYPILI--PKMPTTMELEDAFKQSI-EFKiPSKTKEMNMN---NKLT------------------- 618
gi 367004609 563 SLENTNVILTKLHQKYPILV--PDLPSSNEIREAFQKALt-YK-PVITKTFGNT---PKQKi--QINKS------El--- 624
gi 363754629 567 SLINTKLVLNKLHEKYNVLV--GEIPSEQAVNKAFSSAL-NYQ-PTITKMMGGR---SKR-------------------- 619
gi 754415585 568 SYENVLKILDNLRDKYPVLI--GELPASGIIESAFSSAL-NYK-PSYHKVMGKSggqGKAN---KKKATgeketsNi--- 637
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121919425 625 qshQEARAKKAPRMEYFSVR-L-D-NSRVNSILDAVFAgK--DA----STSK-MYMQLKQTRRVQNEFHVTLMH-RASA- 692
gi 74692909  616 ------PRNTKYKPTYWGAE-LsD-PKLFINQVSDLIVrK--RP----EYLR-GVLDIVEEAMIQKSFHVTLIH-CSAK- 678
gi 74605133  617 -------------PVYFSAN-ViD-TDLLLQHVRKTIEtH--AS----EYPS-LL-KSLDSTPFKDALHITLYHkSQIR- 672
gi 19924244  610 --iTGSSTCFKKAPRYFGVL-L-D-RKTVESSLVQVLTiA--NL----QWQE-AFSRYT----LQDSFHITMIH-ESQK- 671
gi 366988261 614 --tVSGTPKKKVRPAYFSVN-IkD-GTPIKELISNVIEkP--SNi--sEDAQtILKNLLQNDNFQESFHITLAHvMQGK- 684
gi 403214128 625 --kDPLLKPKKLKPVYFSAN-V-S-VDLVKSAIDTLIMqNlgKIa--eEGNQ-YLTSLFAEDKFQKAFHVTLSH-RAQS- 694
gi 410074281 619 ---------KKINPAYFSAN-L-DnKDKLIVAIMQLMEdD--SSnnhgINFE-PLEKLLDENLFQPGFHITLSH-VAQG- 682
gi 367004609 625 --nSINDNKTKISPVFFSAHlL-D-DAIIFDIFKDFVNvP--AFt--kSEKL-VIEDMLKNRSFQSELHVTLAH-VASC- 693
gi 363754629 620 -----STRNEKYKPVYFAAE-InD-VQRLRREIDDLIKrs-------iPNSA-GLSSLIDVTSLKDSFHVTLIHiNAGKk 684
gi 754415585 638 --gNPTKRMKVKPPVYFSID-I-PnKAVVTSRIQDLLIqK--GSl--aNVDK-SFGDLLKT-KLMNEFHVTLAH-CIQA- 705
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121919425 693 --S----DN------PPY----WDKLMKL-SEASqqtgd---------kswePE--------------L-----GTCSVH 727
gi 74692909  679 --Rgn-kEE------KDM----WAEYNKRyANHL------------------VKpekapcqppkyietT-----DFIKFS 722
gi 74605133  673 --Svg-iKA------KQM----WAKYLDRyKEYL-------------------SkennseatkniiatE-----DSVSFK 715
gi 19924244  672 --P----VN------SRI----WEQYLQHmHDKNtt-------------------------------kM-----GNISFR 699
gi 366988261 685 --Rgd-pAE------QEL----WKAYLKHyKKILksyndk------eipkliET--------------N-----DFVRFQ 726
gi 403214128 695 --S----SNsgdergKRN----WERYTKHyEPIIkmsest------nnsqenTA--------------LpirtgDIVSMR 744
gi 410074281 683 --KrgdpRD------KIL----WKEYLKEfDPQLteisard----nyqetlfKT--------------D-----YRVKFK 727
gi 367004609 694 --KrggpEL------QQI----WQEYNNRyIPLIkknlkllrikseelpsqiKT--------------D-----DILEFS 742
gi 363754629 685 gtK----FE------KDM----WCEYNKRyNNLLlkngsnld---kvqpkylAS--------------T-----DSVKVE 728
gi 754415585 706 --K----RG------NELekfvWSKYINVfENRKskgn---------------------------------llgYSADLK 740
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121919425 728 LERLIWDDRIMCFVIRlngsstlQINteqgstteelvfESTNPVAHVTVGTASPDIKPKESNDLL----Q--RWl---NE 798
gi 74692909  723 IDKLLWDDKIMTATVStdkliyds------tgeavpilRLLNTYAHITVGTRKAGVQAVYSNELC----RrfHEkhgeEE 792
gi 74605133  716 LRDLIWDKHVILATVSllddthpIvmpdgt---hldhlTCLNKVPHITLALFSNEKTAKYSGELA----Ke-vYefgiQE 787
gi 19924244  700 ITHLVWDDRVICFRVTmnens-------------vwygKTCNPQLHITLGTSSSDVKAFESNFLL----KklRWq---GD 759
gi 366988261 727 PKMICWDDKIVSIVIKfpndecvSDEngll----vtklKCANKIPHITVARLQDNVKAVYSNTIC----K--DVv---EN 793
gi 403214128 745 LSKLIWDDKIVTIIVDllentdnSIAvrsaerevinglNCTNLIPHITIGILQDGVKAYYSNELC----N--Ki----AS 814
gi 410074281 728 LDKLCWDDKIVAVMVKfedtncvTDKdnvt----itglECSNKFPHITIGRLNSDIKASYSNSLC----E--Ri----MK 793
gi 367004609 743 VKKICWDNKILSAIIElgdfkdsNGVilk-------glKCANKVPHITLALLEPGTKPFYSNELC----Q--NVq---AN 806
gi 363754629 729 LKSLLWDTNTVAVLVKvdkecivDKEgnkv-----pllSIITKHPHITIGFIKEGVKAYYSNTLCdlmeE--HHf---EN 798
gi 754415585 741 LKSLIWNDMIATVLVDisl-iyrDGSsne------lsvKSANKFPHITYALLSEGVKPFFSNSLAe--dA--SKf---DD 806
                        330       340
                 ....*....|....*....|....*...
gi 121919425 799 GS-GGNTGIGELPVKGSVMLKGSVRGVL 825
gi 74692909  793 GS--FSEGMNCIRFPEPVQVVAAVRINi 818
gi 74605133  788 SD-T-DTGMISLGTTDNLQFSGKVCINL 813
gi 19924244  760 EVdSTDGNVRYLTVLPKIIIEGMLEPVy 787
gi 366988261 794 RD-A--TNINHVELVDSPSLTGNVCINL 818
gi 403214128 815 G--GNTSGCFELNFVDSKVFDAEVYINL 840
gi 410074281 794 DD-ADGESSYYLNFNDSEEFVADVCINL 820
gi 367004609 807 NI-G--KNIRVYDISELKMYQAAISIHL 831
gi 363754629 799 GS--FPGGLNCLNFEYPLFLDSTVCTFL 824
gi 754415585 807 QG-SFDNGVHILHFDDEPVLKqlpvivn 833
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