5MQ0


Conserved Protein Domain Family
cwf21
?
pfam08312: cwf21 
Click on image for an interactive view with Cn3D
cwf21 domain
The cwf21 family is involved in mRNA splicing. It has been isolated as a subcomplex of the splicosome in Schizosaccharomyces pombe. The function of the cwf21 domain is to bind directly to the spliceosomal protein Prp8. Mutations in the cwf21 domain prevent Prp8 from binding. The structure of this domain has recently been solved which shows this domain to be composed of two alpha helices.
Links
?
Statistics
?
PSSM-Id: 462421
Aligned: 149 rows
Threshold Bit Score: 27.7771
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
?
Program:
Drawing:
Aligned Rows:
Download Cn3D
PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
5MQ0_R        65 ETHMEKREIEVQVSELRDRLEEEEtLSEEQIDKKCEALRAKLTNE 109 baker's yeast
Q24HH5        58 IEHEKKREIQVKLMELRDKLEELG-ESEDKIQEKLNKLEEKLRTK 101 Tetrahymena thermophila SB210
EEH56511      60 LEHNRKREIERKLVELEDDLEERG-IAREEIDEMLKDARAKYERE 103
XP_002500797  58 LAHQRKREIEVKLAQLEDDLEEKG-VDAEEIAERLKEARVKFERE 101
AQK96459       9 IEHERKRQVELRLLVLREALEEQG-YMEAEIEARVDEARKATEAE 52 
XP_008679811  63 LEHDRKRQVEVKLLVLRDALEEHG-YTEDEIEERVAEARKAAEAE 106
EEF45815      58 LEHDRKRQIELKLVVLEDKLIEQG-YTDAEVKEKVDEARKTLEAA 101
XP_009149725  59 LEHDRKRQIHLKLAVLEDELSDQG-FSDAEIAEKLEEARLKFEAA 102
NP_001118799  59 LEHDRKRQIHLKLAILEDKLADQG-YSDIEIAQKLEEARVSLEAA 102
XP_004246069  59 LEHDRKRQIQLKLLVLEEKLADQG-YTDAEISEKLEEARRNLEAT 102
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap