Conserved Protein Domain Family
COG4

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pfam08318: COG4 
COG4 transport protein
This region is found in yeast oligomeric golgi complex component 4 which is involved in ER to Golgi an intra Golgi transport.
Statistics
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PSSM-Id: 336998
View PSSM: pfam08318
Aligned: 130 rows
Threshold Bit Score: 149.648
Threshold Setting Gi: 855314493
Created: 26-Mar-2017
Updated: 23-May-2017
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74582617  163 LKEITESLHTLFWREFHKAARNQDQKEITRYFKLFPLIGKEKEGLEAY------------WHFFGGIIASKARATLDEPP 230
gi 122021680 241 iASARESAREKLLEKFRVASRSNDKLTIMQATRLLTQLGFSEEGCSLY------------CTWLCEHTIAALKKMVDREL 308
gi 74831328  282 IVNARQTVREKLMKRFYSAKVVNDKQTIMDTVRLLTLLGFRDECCCMY------------CSWMCEHTIVALNKMVEREL 349
gi 290997618 118 fKKSEKKIKEIVSSKMKEALRDENETQIKRFSKLFSPLCMNEDGLSLY----------------VDFLSDKCRKELESLD 181
gi 294879757 114 LED---EVCSLVRKAFDNAIISGDKDGVSKCGRLFYPLGMTTEAVARY------------VRFIRQTLAAQCKQKLSSVT 178
gi 855314493 153 mKKSTETLIRALTEQFQSSMTKNKQTQVYRYCHLLDSLGEGRSILQPFlslssfelthrlVQYLMTPLVEQTKKDNQLLQ 232
gi 569378503   3 llDSKERLQHLVKEKCENALSGNDLKVVLEFARLYPYLDLSKEGLSLY----------------CEALKRETMMELENRS 66
gi 168022969 152 lfESKQKLEAIFRKKLAAAVESKDHDNVVRFVKLYPPLRLQEEGLRSY------------VAYLRKVVAMRARGDYEVLI 219
gi 242042075 190 llDIKRRLEGLARRRLAAVIDAQDHPAVLRLVRLFPLLGLADEGLQVY------------VAYLKKVVALRARADFEHLA 257
gi 302756753 154 llESKRKLEEVIKKRFYAAVDARDHAGVVRFASLFAPLGLHEEGIKAY------------VSYLRRSVDHRARDGFAAVK 221
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74582617  231 T----------------HALFFAQAFTGLVEHVASIIRAHTPLVQKYYK--AKNTIT-VIEKLQGDCDR----------- 280
gi 122021680 309 Rkmdd---------pteAGMSHLGLVSTVLDAVVAAFENEEEFIRETFG--DAGLLK-LLTELHCKSTS----------- 365
gi 74831328  350 Rkidd---------pneAGMSHLALVSAGLDLVVATFENEEEFVLETFG--DAGLLL-LLTELHSRSTS----------- 406
gi 290997618 182 Everlty----irkqqqQYVSFIDIITQILDIIVSYIEDCEDFVTSNFG--GEKCTIyLINSLQHVCDK----------- 244
gi 294879757 179 AttttsndassssssnvINEKYVNTLTDVFLAVADIIQDHQRNIEEQFG--PINFIM-VLRGLQSEVDI----------- 244
gi 855314493 233 Sqrs----------ahhVGVVVGNLLGGLYQKAVELVDSVEDSFQNCFVneQFAYCY-LLRCVFIHCDTqvgfaflslff 301
gi 569378503  67 Llfdckefv-diknskeEHIPYVSVLEGLVDALFTVINDNVNNLKQMFG--EGSELL-LAQKLYGEADR----------- 131
gi 168022969 220 Ealgstd-----ggrgaGTADFVGILNNIFKDIAFAVEENEDLLFDLAG--EEGVAL-ALVELQEECDA----------- 280
gi 242042075 258 Eltsat-------qptsERLDFVGCLTRLFKDIVLAVEENDAVLRELRG--DDGVAY-AIIELQEECDS----------- 316
gi 302756753 222 Et--------------pDQADFVAALNNIFKDIAEAIEENEELLKSLNG--EDGLVY-AIRELQEECDS----------- 273
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74582617  281 QGSIIVNTMFDVRRIDN-------------LVSSIASYKY--------------------ILLHaklknraFVSDQKELE 327
gi 122021680 366 QCVPVLKDFLKKRQE---------------VLSSVTSAGGintnssssssgnargqfpagSVEAaagspvfPTTSSAVAA 430
gi 74831328  407 QCVPVLKDFLKKRQE---------------VLQAVDCTNNspsprg---------esndnSGRSavtsprqPRALQSRGT 462
gi 290997618 245 MVKKVLDVYEKKRELND-------------ILTAVSKKPN-------------------------------TLPIKKDLN 280
gi 294879757 245 QAIAVIKRLRESRSITT-------------IMEHFQTIADec---------------------------idNNDASSIVD 284
gi 855314493 302 QAGQLFSTFASLRDLSV-------------LFEDSKTRLQay----------------------------iSNEQGVEDA 340
gi 569378503 132 EIHKLLAHYIQHFDLPKlakfvklifilslFFSECSYLNFfacfqennre---------------------yfekllqql 190
gi 168022969 281 RGSLIIKKYIEQRKLLK-------------LTKDIAAHSK-----------------------HdmnfdmnLLAVAAPPE 324
gi 242042075 317 RGTQILRRYADYRKLAR-------------LASDINSYTK-----------------------NllsamgsMASAAGGNE 360
gi 302756753 274 RGSAIVKKYMEFRGLAK-------------LEKEIIAQTN--------------------AEKDivaqsklLMSAGGAAE 320
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74582617  328 RVSLQTLHPILNEMSAIVSKWNISKIFISRLVlrl--------------------sqsDGTSND-----PSVQDNLICAS 382
gi 122021680 431 TVDPRRTDQILEEMSHLVSCCHLYWTFAQSKQq------------------------eYMHGVEatgkqHEQQEVVVSVD 486
gi 74831328  463 TLDPRRTDQILEEMSHLVSCYHLYWTFAQSKQqe----------------------ctQRVREKeggarEQNDGMNQSAD 520
gi 290997618 281 TNDPRVLDLILEEIAEISSNIEVYKQFIAGKCi-----------------------------------nIKTDGKNEMYT 325
gi 294879757 285 EIDLGEKDAVIDEICIIAQRCNQFDHYIHNISrqvvaelgnddkrrlmygevapdekdYNEDHH-----HHKSRNTYGED 359
gi 855314493 341 ALDA--LNPVLNEISLILQHAESFSRYLTGKMndavla---------------asqrvPPDSEMlthypSTANVPADVVA 403
gi 569378503 191 GFPLDKLDELLQEIAHVCSELESFDATMRSYMsd----------------------akQMIEQS-----NNSLLEQEVPK 243
gi 168022969 325 GPDPREIEVCLEEMMLLSQTSEDYFHFMSTKM---------------------------KEAGA-----TSGQLSPRESN 372
gi 242042075 361 GPDPREIELYLEEILALTQLGEDYTEFMVNKI---------------------------RGLRD-----VKPELGPRAMK 408
gi 302756753 321 GPDLRSIEMFLEEILLLIQTSEDYTQYMIGRV---------------------------REAGS-----SGAQLSPRSTT 368
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74582617  383 IFNS-SK---MELLL-K----------KQLLPSLLQLETYYFRRSIETSL---ELEEYYT-------------------- 424
gi 122021680 487 SLWS-SRdnpLMNTV------------QEILGVFVPLQTLYFEAAFEQALr-lQMDALHAaarealmsgtegggdlsark 552
gi 74831328  521 SLWS-SRdnpLMTAV------------QEILAIFVPLQTHYFEAAFHQVLq-iQLDAINAsshehp-------------- 572
gi 290997618 326 LTKE-PI---IYRRI------------QELMSFYIPIDMSFMKQSFFKAI---QLESDEDe------------------- 367
gi 294879757 360 GLPImTD---LTELV------------QELMGEYVLYERSFIIVSTIKAIhedRIDMDD--------------------- 403
gi 855314493 404 ALRS-AE---QKKGLpQggqqpswkamQSLCQSYTALEESYTLYAVNRSIfhvRLDEETR-------------------- 459
gi 569378503 244 NFPA-ET---KINTI-R----------HQYISYYIILEQFNMQYKLYRVL---TTKffflsli----------------- 288
gi 168022969 373 SFKA-GS---FGLSV------------QELVGYYIILEEYFMSENVKKAI---QIDELV--------------------- 412
gi 242042075 409 AFRN-GN---FNKME------------QDLTGFYVIFEEFFMVENVRKAI---RIDEPI--------------------- 448
gi 302756753 369 SFKV-GS---FYRAV------------QELTSHYRLLEEYFMAENVRKAI---KLDEFP--------------------- 408
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74582617  425 -------------------------------------------------------------KVSPWMSSIVDDVMYVTKQ 443
gi 122021680 553 rtgvivhssshhhhhhqsskknetysspsakktanfmtglaalytstaaasggedeempdaAMDQVSITLPDDVFFFLRI 632
gi 74831328  573 -------------------------------------------------------mpsttaAVTAGNNSTKQQVGY---- 593
gi 290997618 368 -------------------------------------------------------------DESSKYSSIINDVFFILQK 386
gi 294879757 404 --------------------------------------------------------------PQQMTSSVVDDVFFVLNK 421
gi 855314493 460 ------------------------------------------------------------------SSTVPEEVFYLFEI 473
gi 569378503 289 ------------------------------------------------------mnednihNEEQLISSSSELSFFVLKK 314
gi 168022969 413 --------------------------------------------------------------ADGMTTSMVDDVFYVLQS 430
gi 242042075 449 --------------------------------------------------------------PDGLTTSMVDDVFFVLQS 466
gi 302756753 409 --------------------------------------------------------------ANSLTTSVVDDVFYVLQS 426
                        490       500       510
                 ....*....|....*....|....*....|....*....
gi 74582617  444 VFQRAFFTVSSLFFTRFVNeSLIPILRNDYY-VYLSHNL 481
gi 122021680 633 ALHRAVNTKSTQIISAVFI-ACIELVQSKLLpvlqlqtt 670
gi 74831328  594 -----GSTTSNKAAATLMT-GLAAAIYNSTTsGSSANTg 626
gi 290997618 387 SLSRAMDSQNVSVVCAIVN-HINGILATDYF-EFVKKDv 423
gi 294879757 422 AIRRSLSSDDIDSACAVMN-HIVQVLSNEYKticldkpl 459
gi 855314493 474 VINRAISQGNVRNIAMVVS-IVKGCIDQYLH-------A 504
gi 569378503 315 IAIRAFNTYDVNAACAVIN-HISNTLDGFYK-EWLDmnl 351
gi 168022969 431 CTRRAISTSSLLSVQQIIN-HTGSLLNNDFS-EALQRKI 467
gi 242042075 467 CCRRAASTASINSVLAVLG-GATSLLSNEYQ-EALQWRM 503
gi 302756753 427 CTRRAVSTSNVHLTLSIVT-CAANLLGNEYK-DALQRKM 463
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