Conserved Protein Domain Family
COG4

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pfam08318: COG4 
COG4 transport protein
This region is found in yeast oligomeric golgi complex component 4 which is involved in ER to Golgi an intra Golgi transport.
Statistics
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PSSM-Id: 311979
View PSSM: pfam08318
Aligned: 130 rows
Threshold Bit Score: 147.688
Threshold Setting Gi: 855314493
Created: 21-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74593597  201 LDNAA---ESLCGLFLREFDKAVKESNGAKITRFFKLFPLIGRSEVGLDVY------------GRYVCQGVAAKARS--- 262
gi 122021680 241 iASAR---ESAREKLLEKFRVASRSNDKLTIMQATRLLTQLGFSEEGCSLY------------CTWLCEHTIAALKK--- 302
gi 74831328  282 IVNAR---QTVREKLMKRFYSAKVVNDKQTIMDTVRLLTLLGFRDECCCMY------------CSWMCEHTIVALNK--- 343
gi 242042075 190 lldiK---RRLEGLARRRLAAVIDAQDHPAVLRLVRLFPLLGLADEGLQVY------------VAYLKKVVALRARAdfe 254
gi 168022969 152 lfESK---QKLEAIFRKKLAAAVESKDHDNVVRFVKLYPPLRLQEEGLRSY------------VAYLRKVVAMRARG--- 213
gi 302756753 154 LLESK---RKLEEVIKKRFYAAVDARDHAGVVRFASLFAPLGLHEEGIKAY------------VSYLRRSVDHRARD--- 215
gi 290997618 115 ntlfkksekkikeiVSSKMKEALRDENETQIKRFSKLFSPLCMNEDGLSLY------------VDFL----SDKCRK--- 175
gi 294879757 108 LKEAKrleDEVCSLVRKAFDNAIISGDKDGVSKCGRLFYPLGMTTEAVARY------------VRFIRQTLAAQCKQ--- 172
gi 569378503   3 LLDSK---ERLQHLVKEKCENALSGNDLKVVLEFARLYPYLDLSKEGLSLY----------------CEALKRETMM--- 60
gi 855314493 153 mKKST---ETLIRALTEQFQSSMTKNKQTQVYRYCHLLDSLGEGRSILQPFlslssfelthrlVQYLMTPLVEQTKK--- 226
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74593597  263 ---NLN---TGt--------------gQQD----GF------FYANTLTKLFEHIAQIIDGHGGLVERHYGPRKM--NRV 310
gi 122021680 303 ---MVD---RElrkm---------ddptEA----GM------SHLGLVSTVLDAVVAAFENEEEFIRETFGDAGL--LKL 355
gi 74831328  344 ---MVE---RElrki---------ddpnEA----GM------SHLALVSAGLDLVVATFENEEEFVLETFGDAGL--LLL 396
gi 242042075 255 hlaELT---SAtq-------------pTSE----RL------DFVGCLTRLFKDIVLAVEENDAVLRELRGDDGV--AYA 306
gi 168022969 214 ---DYEvliEAl--------------gSTD----GGrgagtaDFVGILNNIFKDIAFAVEENEDLLFDLAGEEGV--ALA 270
gi 302756753 216 ---GFA---AVk--------------eTPD----QA------DFVAALNNIFKDIAEAIEENEELLKSLNGEDGL--VYA 263
gi 290997618 176 ---ELE---SLdeverl----tyirkqQQQ----YV------SFIDIITQILDIIVSYIEDCEDFVTSNFGGEKCt-IYL 234
gi 294879757 173 ---KLS---SVtattttsndassssssNVI----NE------KYVNTLTDVFLAVADIIQDHQRNIEEQFGPINF--IMV 234
gi 569378503  61 ---ELE---NRsllfdcke-fvdiknsKEE----HI------PYVSVLEGLVDALFTVINDNVNNLKQMFGEGSE--LLL 121
gi 855314493 227 ---DNQ---LLq--------------sQRSahhvGV------VVGNLLGGLYQKAVELVDSVEDSFQNCFVNEQFayCYL 280
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74593597  311 IERLQLEADVQ-----------GGIVVDTWSDERHIDRKLMDIK------------SYAFTFlvqsflp--pqrtatPhA 365
gi 122021680 356 LTELHCKSTSQ-----------CVPVLKDFLKKRQE--VLSSVT------------SAGGINtnssssssgnargqfPaG 410
gi 74831328  397 LTELHSRSTSQ-----------CVPVLKDFLKKRQE--VLQAVD------------CTNNSPspr---------gesNdN 442
gi 242042075 307 IIELQEECDSR-----------GTQILRRYADYRKLARLASDIN------------SYTKNL---------------L-S 347
gi 168022969 271 LVELQEECDAR-----------GSLIIKKYIEQRKLLKLTKDIA------------AHSKHD---------------M-N 311
gi 302756753 264 IRELQEECDSR-----------GSAIVKKYMEFRGLAKLEKEII------------AQTNAE---------------K-D 304
gi 290997618 235 INSLQHVCDKM-----------VKKVLDVYEKKRELNDILTAVS------------KKPNTL---------------P-I 275
gi 294879757 235 LRGLQSEVDIQ-----------AIAVIKRLRESRSITTIMEHFQ------------TIADECi----------------- 274
gi 569378503 122 AQKLYGEADRE-----------IHKLLAHYIQHFDLPKLAKFVKlifilslffsecSYLNFF---------------A-C 174
gi 855314493 281 LRCVFIHCDTQvgfaflslffqAGQLFSTFASLRDLSVLFEDSK------------TRLQAY---------------I-- 331
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74593597  366 NSPAT------QQSAAEDE-GVDMKEIDGLLNEMTVMLSRWSLYTRFL---------------AETCn------------ 411
gi 122021680 411 SVEAAagspvfPTTSSAVAaTVDPRRTDQILEEMSHLVSCCHLYWTFA---------------QSKQqeymhgv------ 469
gi 74831328  443 SGRSAvtsprqPRALQSRGtTLDPRRTDQILEEMSHLVSCYHLYWTFA---------------QSKQqectqrvr----- 502
gi 242042075 348 AMGSMas--aaGG-----NeGPDPREIELYLEEILALTQLGEDYTEFM---------------VNKIrgl---------- 395
gi 168022969 312 FDMNLla--vaAP-----PeGPDPREIEVCLEEMMLLSQTSEDYFHFM---------------STKMkea---------- 359
gi 302756753 305 IV--Aqs--klLMSAGGAAeGPDLRSIEMFLEEILLLIQTSEDYTQYM---------------IGRVrea---------- 355
gi 290997618 276 ---------------KKDLnTNDPRVLDLILEEIAEISSNIEVYKQFI---------------AGKCi------------ 313
gi 294879757 275 ----------dNNDASSIVdEIDLGEKDAVIDEICIIAQRCNQFDHYIhnisrqvvaelgnddKRRLmygevapde---- 340
gi 569378503 175 FQENNre--yfEKLLQQl--GFPLDKLDELLQEIAHVCSELESFDATM---------------RSYMsdakq-------- 227
gi 855314493 332 -----------SNEQGVEDaALDA--LNPVLNEISLILQHAESFSRYL---------------TGKMndavlaasqrvpp 383
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74593597  412 ---------ANEEQKFELPQFLKE-SA---LSK-----------KIEDRVISPFNTMTTFFFRRSVEKAF---QL----- 459
gi 122021680 470 ---eatgkqHEQQEVVVSVDSLWS-SRdnpLMN-----------TV-QEILGVFVPLQTLYFEAAFEQALr-lQM----- 527
gi 74831328  503 --ekeggarEQNDGMNQSADSLWS-SRdnpLMT-----------AV-QEILAIFVPLQTHYFEAAFHQVLq-iQL----- 561
gi 242042075 396 -------rdVKPELGPRAMKAFRN-GN---FN------------KMEQDLTGFYVIFEEFFMVENVRKAI---RI----- 444
gi 168022969 360 -------gaTSGQLSPRESNSFKA-GS---FGL-----------SV-QELVGYYIILEEYFMSENVKKAI---QI----- 408
gi 302756753 356 -------gsSGAQLSPRSTTSFKV-GS---FYR-----------AV-QELTSHYRLLEEYFMAENVRKAI---KL----- 404
gi 290997618 314 --------nIKTDGKNEMYTLTKE-PI---IYR-----------RI-QELMSFYIPIDMSFMKQSFFKAI---QL----- 361
gi 294879757 341 -kdynedhhHHKSRNTYGEDGLPImTD---LTE-----------LV-QELMGEYVLYERSFIIVSTIKAIhedRI----- 399
gi 569378503 228 ----mieqsNNSLLEQEVPKNFPA-ET---KIN-----------TIRHQYISYYIILEQFNMQYKLYRVL---TTkfffl 285
gi 855314493 384 dsemlthypSTANVPADVVAALRS-AE---QKKglpqggqqpswKAMQSLCQSYTALEESYTLYAVNRSIfhvRL----- 454
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74593597  460 ------DEQPTgltlnl--------------------------------------------------------------- 470
gi 122021680 528 ------DALHAaarealmsgtegggdlsarkrtgvivhssshhhhhhqsskknetysspsakktanfmtglaalytstaa 601
gi 74831328  562 ------DAINAsshehp--------------------------------------------------------------- 572
gi 242042075 445 ------DEP----------------------------------------------------------------------- 447
gi 168022969 409 ------DELVA--------------------------------------------------------------------- 413
gi 302756753 405 ------DEFPA--------------------------------------------------------------------- 409
gi 290997618 362 ------ESDED--------------------------------------------------------------------- 366
gi 294879757 400 ------DMDD---------------------------------------------------------------------- 403
gi 569378503 286 slimneDNIH---------------------------------------------------------------------- 295
gi 855314493 455 ------DEETR--------------------------------------------------------------------- 459
                        490       500       510       520       530       540       550
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74593597  471 -------qrplkADPP-HITSAVDDIMYIVNKVLQQSLSTSQIAVVTSVVPTLSRVLGSDFI-GMTQRKM 531
gi 122021680 602 asggedeempdaAMDQ-VSITLPDDVFFFLRIALHRAVNTKSTQIISAVFIACIELVQSKLLpvlqlqtt 670
gi 74831328  573 ------mpsttaAVTA-GNNSTKQQVGY---------GSTTSNKAAATLMTGLAAAIYNSTTsGSSANTg 626
gi 242042075 448 ------------IPDG-LTTSMVDDVFFVLQSCCRRAASTASINSVLAVLGGATSLLSNEYQ-EALQWRM 503
gi 168022969 414 --------------DG-MTTSMVDDVFYVLQSCTRRAISTSSLLSVQQIINHTGSLLNNDFS-EALQRKi 467
gi 302756753 410 ------------NS---LTTSVVDDVFYVLQSCTRRAVSTSNVHLTLSIVTCAANLLGNEYK-DALQRKM 463
gi 290997618 367 ------------EDESsKYSSIINDVFFILQKSLSRAMDSQNVSVVCAIVNHINGILATDYF-EFVKKdv 423
gi 294879757 404 -------------PQQ-MTSSVVDDVFFVLNKAIRRSLSSDDIDSACAVMNHIVQVLSNEYK-TIcldkp 458
gi 569378503 296 ------------NEEQ-LISSSSELSFFVLKKIAIRAFNTYDVNAACAVINHISNTLDGFYK-EWLDMNL 351
gi 855314493 460 ------------S------STVPEEVFYLFEIVINRAISQGNVRNIAMVVSIVKGCIDQYLH-AYLlsvi 510
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