Conserved Protein Domain Family
PIG-X

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pfam08320: PIG-X 
PIG-X / PBN1
Mammalian PIG-X and yeast PBN1 are essential components of glycosylphosphatidylinositol-mannosyltransferase I. These enzymes are involved in the transfer of sugar molecules.
Statistics
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PSSM-Id: 311980
View PSSM: pfam08320
Aligned: 103 rows
Threshold Bit Score: 112.78
Threshold Setting Gi: 403167009
Created: 22-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110815899 306 PTGLHPTMTI--SM---PP--SS------LNsPpappDATCALHTYLTLPSTIFGDKYQLSTTDPLfldshnlvA---LH 369
gi 74854533  383 KSGFHRELVI--NVt-lKSplRD------TVp------GVCKIMVLENLDQGIFVDRYEVDEIER---------FggpKV 438
gi 195999306  68 leGFHRDLIT--KI---NF--RSevksnlTS-F----SDQCSLLLVERLPTGIYVDLDQVAEMERL--------LkdiSV 127
gi 330804076 366 KSGFHRELVS--NVtikSP--PT------LK-I----PRECKLLFLEHFDQGIFVDRYEVDEIERF--------Gg-pKV 421
gi 260809065  75 NHGFHRDVVTevTL---PV--AM------VT-P----PMSCRLLLVETVPAGMYVDLHQVTFRTDF--------Gg-pQV 129
gi 954374348  34 gDGFHRQLSN--FI---YL--SS------MN-R----LVNCSVVYRVTVPSGAYLDVDQMPASIR---------N---MF 83
gi 541040910  41 gAGLHRRLIV--DA---SL--GS------SN-R----FIDCQFAYRFVIPAGAYIDMDSVPPLRDH--------H---IA 91
gi 544410130  24 KDGFHRDLLI--KVk-fGEsiED------L--------QTCRLLIKQDIPAGLFVDPYELASLRER--------NiteAV 78
gi 351694919  17 KDGFHRDLLI--KVk-fGEstED------L--------QTCRLLIKQSIPTGLFVDPYELASFQEK--------NiteAV 71
gi 395519213 113 KDGFHRDLLT--RVk-lGTnvEN------S--------QTCNVLIKYHLPSGLYVDPYELASLQEH--------NvteAM 167
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110815899 370 AVAGETDLEAPDWFVSRWGSNWLLELATP---SESDQVPEEWNVTIPLHLRYLRP----S--E-S--GYRSASVPWPVV- 436
gi 74854533  439 VIYQLIDLEKPSTSSTQN--FVSI----IkqfNTTGSATQDIQLTLPIHLRYQNPlfsdNgdS-N--TFRQSIISSPQI- 508
gi 195999306 128 ISSDRIDVEKPAHLSTEHLLLVYARINPI-------TDVRSTKVSLPIHLRYHLP----Qd-DwY--GYTEVVMPRPMLi 193
gi 330804076 422 NIYQLIDLEKPSATSTQN----YISVVKEf--TVNSEPEQTIQVTLPIHLRYQNPi--nSn-Q-D--AYRNTHISSPMI- 488
gi 260809065 130 LALSDIDVEQAAHQSSHHRLLLYSPL-------QQNPKGFTWRVTLPVHLRYHRW----Ag-E-GedTSATVRLEGPDV- 195
gi 954374348  84 YSYKPFFVEAPAWTSVDQ--TVLIESSk----RMYNAFIFEDVIEFPIHFRYQKP----Tk-G-G--LIVKVRFYAPDV- 148
gi 541040910  92 HVY--FDTEVPKERSTDTP----VYICSKr--ALRKNFVFNDHLELPFHLRYHKP-------T-G--NDAIVKFSPPRL- 152
gi 544410130  79 MVSENFDIEAPNYLSKES--EVLI----Ya--RQDSQCVDCFQAFLPVHYRYHRPh-----sH-D--GETSIVVNHPDL- 141
gi 351694919  72 MVSENFNIETPSYLSKES--EVLI----Ya--RQDARCADCFQAFLPVHYRYHRPh-----sE-D--AETLIVVGNPDL- 134
gi 395519213 168 IIQDSVDLEAPDYLSEEL--DVFV----Ya--KSDSQCSECFRTILPVHCRYHQPk-----eK-E--EKTFVVVKNPEL- 230
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110815899 437 FWAC--TAE----------D----GTK------MGVNPFDRVNLGWEGLFGTRTMFYQLHPSS---D----R-------- 479
gi 74854533  509 YLSCepTNS----------V---------------------------------------LNNN---DnsnnDnwnlitny 536
gi 195999306 194 LIHCdkELP----------Ef--qCQP------KYTAPCSNSNKSS-------CVWNLLYDNEnedS----G-------- 236
gi 330804076 489 FIQCepTNS----------V------T------ESKSTFD----HWKLITSFSPLFEH-------------T-------- 521
gi 260809065 196 LMHCegDRPvtt-----pcE----ESR------LFPAPCDAESRGV-------CLWQLLKGKA---E----P-------- 238
gi 954374348 149 LLRCldPKFldllnftggaD----DSR------LVEAPC---NFYYNYTSTLLCLYLHVKESS---V----S-------- 200
gi 541040910 153 LVKCveNAT----------I----LSEknctkfIRKAPCDCLSDA-------KCDWVILAAK----E----S-------- 195
gi 544410130 142 LMFCdqEFP----------IlkcwAHS------KVAAPCALENEdi-------cqWNKMKYKS---Vyk----------- 184
gi 351694919 135 LMSCdqEFP----------VlscwAQS------EVAAPCALKSKnv-------cqWSCLKYQP---Ihk----------- 177
gi 395519213 231 LVSCynDFP----------SlncwKES------DMEAPCSVRNKhi-------cqWSKVKYKS---Vnq----------- 273
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 110815899 480 --------LVEELEVPVLQLDdkgffQSKAIELGTMIVIGLGSLWVLWKL 521
gi 74854533  537 nlllddisKSISINVPVGQLN-----DNDSVKFYTLLVTVIGSILERPHH 581
gi 195999306 237 --------NEIILKVPVGIVK-----HGVLVSIGTIISAIAGTIILIIAI 273
gi 330804076 522 --------KSLFIDVPVGQLK-----DLESVKFNTLTVTVIGSILVIATI 558
gi 260809065 239 --------LL--FQVPIGQQS-----HAVLVITGTTAVAALGSLLILVAa 273
gi 954374348 201 --------Y-ADIDIPTPDIS-----YKVPVTIGLILCIIYSFCTTVYTL 236
gi 541040910 196 --------APIEMLVPTGNPA-----IRSFVIFVTFAFIFGGMCVIVYFL 232
gi 544410130 185 ---------nvTLQVPVGLTI-----HTSLVCSVTLFVTILCSTLILVAV 220
gi 351694919 178 ---------nvTLHVPVGLSI-----HSSLVCSVTLLITILCSTSILVAV 213
gi 395519213 274 ---------nvTLQVPVGLRE-----HCLLVCAMTLLVTVLCSVFILRAV 309
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