Conserved Protein Domain Family
ACC_central

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pfam08326: ACC_central 
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Acetyl-CoA carboxylase, central region
The region featured in this family is found in various eukaryotic acetyl-CoA carboxylases, N-terminal to the catalytic domain (pfam01039). This enzyme (EC:6.4.1.2) is involved in the synthesis of long-chain fatty acids, as it catalyzes the rate-limiting step in this process.
Statistics
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PSSM-Id: 311985
View PSSM: pfam08326
Aligned: 120 rows
Threshold Bit Score: 471.628
Threshold Setting Gi: 219130617
Created: 21-Jul-2016
Updated: 4-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5I6I_A         704 ALDDPSRVKQAQPFVGQL--PQYGSP------V-VVG-------SK-PAQRFAVLYGTMCDILNGYD-----NQVVMQQK 761
gi 223995593   725 ELENPENVTTATIFSGDLdvTGWGSCdt---aStSTG-------SKrPHITLRRAMNRLKCGMGGYVi----TPAIIDSV 790
gi 219130617   756 ALDNPENVATVSVFEGDLqvTGWGQSiarnttSsSNGstsnngtRN-AHLVLRKAVQALHRATDGYIl----LPETIDAA 830
gi 301093012   766 ELDDPSCVKKSDVFMGKL--PSA---------EnTNGs-----sTK-SVHKMRKSLAVLKCVLQGYYapedlTQ----KA 824
gi 855308001   897 kLDDPSKVRRAQVFTAKL--PTFEVS------SsVQV-------KR-PHHLIKIAISLMEAFINGYWvp--lNQ--IDNS 956
gi 168041186   732 ELDDPSAVRKAQPFEGGF--PPLGLP------TaVAA--------K-VHQRCADALEAARNILAGYE-------HDLDEV 787
gi 685342799   741 DLDDPSAVRKAEPFHGGF--PRLGLP------TaISG--------K-VHQRCAATLNAARMVLAGYE-------HKVDEV 796
gi 302811970   734 DLDDPSAVRKAVPFSEGF--PALGTP------IpVPG--------K-VHHRCALIINASNMILAGYE-------HNVDEV 789
gi 1028569116  801 vLDDPARVQRATVFEDPL--PVIGAP------T-VVG-------DK-VHQQYKYVRSSIEAILDGYE-----PSTDAGLL 858
gi 465795804   747 AVDDPTKITRAEPFVGCL--PDYGLP------E-VQG-------TK-AHQRFQAALDTLHHILDGYD-----QSDAQDEA 804
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5I6I_A         762 LKEFIEVLRDPKLPYSEFSAQFSALHARMPHKLDAQLT---QVL---------------ERAQNR--G--AEFPARQLLK 819
gi 223995593   791 MHDIEDAVKDPSLPVYEIDEHLSVLSGRIDGGLYDELSnllSDF---------------KEKCASgaNdsMRFPADQVKH 855
gi 219130617   831 MADLMQAVADPFLPVLEIREQLSVLSSRLPATLLRSIStmvREY---------------------------ENPA----- 878
gi 301093012   825 LVDLFQVLNEPLLPVEEIREAMSSLAGRIPLDVFAKITdkiQTF---------------KKAVAEdpTaaHEFNAAEIAD 889
gi 855308001   957 LDSFLEAVHDPSLPFYEYLDVLSTMEACLPDSLKEELN---AVLfqqtlpdssprstsqEEERQVtqSfrEEFPAKQIRQ 1033
gi 168041186   788 VKTLLSCLDDPQLPLLQWQECMAVLATRLPKDLKSQARh----------------------------FliTDFPAKALTG 839
gi 685342799   797 VQDLLNCLDSPELPFLQWQECFAVLATRLPKDLRMMLEskyREF-----------------ESISrnSltADFPAKLLKG 859
gi 302811970   790 VQTLLSCLDDPQLPVLQWQECIAVLASRIPTNLKARLDlklKEY----------------EASSGseRgaADFPAKGVRE 853
gi 1028569116  859 VKRLDTLLADKDLPQLEFTEVLGALVGRIPAGLGDALL---KIV---------------NEYHAS--GdpDVFPADSLRH 918
gi 465795804   805 VCTFIECLRMPSLPYAQAGAVLSTLSGRLPGNTEAELR---AEM---------------ERAEAA--G--TPFPAQAMRR 862
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5I6I_A         820 VFNKFLDDnvpnktDQD---LLKSTLEPLTSVLNLYLDGQKA------RELNLIADLLSMYADVECQFS-GRrlQDEEAI 889
gi 223995593   856 LVAVHMGSikd-esERA---AFSALSTPLVDAAEPYTKSRAVsapgaeRVLSGFLDILREWITVERCFCdGV--AYADAV 929
gi 219130617   879 -LASHVSSisd-tsARA---TFEALITPLREAVLPYNRGKASgvpgaqRAVDSFLIALEKWTANERWFCdGK--SYADAV 951
gi 301093012   890 ILDEHKKTldt-drKRS---DFEASVVALRDITTKYKHGLAS------GEEAVLTELINEYFTVETVYAnSH--NIEDVV 957
gi 855308001  1034 --------------NRA---ELQQIVGPLYEVVGKYGSGLEG------YAISILFHLLDVYIVNERSYEtLG--KPGDTM 1088
gi 168041186   840 IIETFLAKsp--ekDRV---TLDRLVEPLLLLTRSYEGGREG------HACSVVQTLFNGYLHVEELFNeNA---QADVI 905
gi 685342799   860 ILEAHLLScd--ekDRG---ALERLIEPLMSLAKSYEGGRES------HARVIVHSLFEEYLSVEELFNdNM---LADVI 925
gi 302811970   854 VLEEFLASat--dqDRA---TQERLVEPLLTLAKSYEGGRRG------HACSIVKALFEEYLLVEEHFSqGTg-TQADVI 921
gi 1028569116  919 LIDVAVNDmp--idERI---LFTGIIVSVQNVIDTYAGGLTL------HANAVFMKLLDRYISVESIFN-SA--RYETAI 984
gi 465795804   863 RVDGALASv----tDTAahlALSTALAPLYVLLDAHALGLWY------NEIQTLSALLERYDAVESQFQrGP-----EAV 927
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5I6I_A         890 LKLRDQYKDN-IQKVVNTVLSHKNVMSKNSLVLALLDEYR------PNkpnv----------gnvGKHLRPVLRRLTEL- 951
gi 223995593   930 DSLRKANKGN-AAGVLQMCRSHALLNSTATVILRIIDSIAeagktdINapsstgkiasvvlgadgLEDTTPCLTDIAAMr 1008
gi 219130617   952 EELRQGHKND-PGYILSVCRAHEQLQTTSKLVTSIMTAIGvgskinPTggag---------tesvILHAESAISEIGSMg 1021
gi 301093012   958 MALRQQNSAD-LNKVFSIARSHKALEAKNKLLLQLLAQMArgtavtPRksmk-------------sasFVPLLEKLATF- 1022
gi 855308001  1089 DFSRKNTDMAyCEQVWRCMFSHIQMKQKGDLIIRVMNLLS------SLipsm----------heeSNHLNKVLQEISSY- 1151
gi 168041186   906 EGLRQQHKKD-LSKVVDIVLSHQGVKMKNQLILRLMGALVypn----------------------paaYRDQLIRFADL- 961
gi 685342799   926 ERMRQQYKKD-LLKIVDIVLSHQGIKNKNKLVLRLMEQLVypn----------------------paaYRDKLIRFSTL- 981
gi 302811970   922 ESLRHVHKKD-LWKVVDIVLSHQGIKTKNALMLRLIEALVypn----------------------psaYRDQLVRLAAL- 977
gi 1028569116  985 LDLRDKHKSD-LMVVQQLALASSKADTRCEMVLELLNTVR------SDce-------------eiKQVFMPYLESLADF- 1043
gi 465795804   928 LHLRTASDGN-LDEVLSLQVSHEGVVRKNALLLTLLTQYV------QHsdmas--------ktehAQRMVAVLRALSQL- 991
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5I6I_A         952 ESRQSAKVSLKAREVLILCALPSLEERTAQMEHILR-----SSVVQSRYgetg-wshRRPDREVLKEVVDSKYTVFDVLT 1025
gi 223995593  1009 GNEIYDILSQRSRNVLIEESLPSIEERKKRVEQSVKslaggDSAAQ------------------IQDLIDDNIIGSDIIF 1070
gi 219130617  1022 SNDLYREVALKARKLLMQESLPSLELRKGRFVAAAShvataD---------------GANLSSTVTDLLADQTPMVDLLF 1086
gi 301093012  1023 KEKQYSLVALEARQLLIDNKMPSYRDRLSQVEKVLK-----DYIANGS---------STNLAEACANLLDQSQPLFDLLI 1088
gi 855308001  1152 SDHSSTSISLEARQLLLQRKLPSRQEELEVVRNALLnleacKTAEERESe--------------LQKLVDQSNDVRQPLM 1217
gi 168041186   962 NHSNYSELALRASQLLEQTKLSELRSNIARNLSEL------EMFTEDGGeghhtgkrRSAIQERMEALVDAPLPVEDALV 1035
gi 685342799   982 NHTNYSELALKASQLLEQTKLSELRSNIARSLSEL------EMFTEDGEnmdt-pkrKSAINERMEDLVSASLAVEDALV 1054
gi 302811970   978 SDSNYTELAVKSSLLLEQSKLSGIRADIARSLSEL------GMFTEDENgsk--rsgKSAIDERMEYWVDAPVAVEDALV 1049
gi 1028569116 1044 KGRSTAKVSLKARELLIYFQLPSAEERRAIMLTQLR-----GGIKSRRTdgiagdanLQFDYSALTKLIMAQQSILDVLP 1118
gi 465795804   992 RGADTAPVALKAREILIQAAMPSLSERQAQMEEVLR-----RSTVRSEEg------vVTPSLEVLRELSDLPYNVSDVLH 1060
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5I6I_A        1026 LFFA---HEDPY-VALAALEVYVRRAYRAYNL-REVRYHDeE---RPYFIDWDFA-----LRKSganqtessmhmqsvvp 1092
gi 223995593  1071 PLLK---DATDAnAQLGALELAARKQYRTYDL-KEFNPMPdQn-------sLKFTfhnkphasvfsstacitsmtd---- 1135
gi 219130617  1087 PLLK---SSSSGlESVGLAEIFVRRMYRSFSMkDIIRDGErRs--------FKFAfmekqaegavsnlstvaslmdlkrv 1155
gi 301093012  1089 SLLD---HEDQK-IRELALELYALRVYRSYLI-ESMETMSfN---DIFAKTFQFKspvvdalavgvapaesyddlasllr 1160
gi 855308001  1218 EVLH---DTDNAsLASAALECYLRKIYRPYIL-ANVKPCLqD---VATAFGFDFTsespeLPTGlrpsasfssldnspl- 1289
gi 168041186  1036 ALFD---HSDHT-LQRRVIESYIRRLYQPYLVpGSVRMQWhR---SGLIATWQFWeeyppPTAEklrtakvt-------- 1100
gi 685342799  1055 GLFD---HSDHT-LQRRVVETYIRRLYQPYVVkESIRMQWhR---SGLIASWEFL-------EEhmerkniglddqe--- 1117
gi 302811970  1050 ALFDhgdHGDHT-LQRRVIETYIRRLYQPYLVkGSVRMQWqR---SAMLASWQFYeegplRVAAaaee------------ 1113
gi 1028569116 1119 SFFY---DADEG-IRAIALYTYVLHTYQAYSI-TSIKQHLgG---SPTVFTWEFV-----LRQaqgtsstaltrisslg- 1184
gi 465795804  1061 SFFA---HAQMP-VAYAALVTYILRVYRAYDI-VGINFATeQldrERALITWYFQmsaevLSNRakekerqasstd---- 1131
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5I6I_A        1093 sspatpve------------ndfkrihsisdmtylarrtrdepIRKGVIVPCKDLLDAEE---ALSRALEVLplahketk 1157
gi 223995593  1136 -----------------------lsralsssklsdlnrsdssgSLQTLLKVCNSFTDIYEdagAIQAMLKEFpqyagt-- 1190
gi 219130617  1156 vss-------------gslmetndepsesggvipvkqgipadtLRIGVCMVVDNVSDVADa-dTIQNVSSQFvan----- 1216
gi 301093012  1161 rnssassldlgeqnseesseeqepaekplakpvesyqkispsfERHGAIARLANLETFQK---SFTDVMSLFplakk--- 1234
gi 855308001  1290 -----------------------------mspkspmsdspkssFAHGIILHAKDTQHIRS---ILPRALRMFgii----- 1332
gi 168041186  1101 -----------------------------------ddddsrgvPRWGAMVILTSLQVLSN---AVGAALKDAesilsptt 1142
gi 685342799  1118 -------------------------------tpekglvekrseRKWGAMVIIKSLQFLPS---IISAALTETnhnehvs- 1162
gi 302811970  1114 ---------------------------------------sepvKWRGAMAVLSSLNTLSS---TVRTALEEWfgvtq--- 1148
gi 1028569116 1185 ---------------------------sfrdlrslnygsdfatPRRGAICAFESVDQLCT---HLPRILAEYgvskst-- 1232
gi 465795804  1132 -------------------------------lahhmrrrtrpkLRIGAMTTCPSLSELPT---VLRRVLKYYgeg----- 1172
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5I6I_A        1158 dkdrkqqpgiaadlaqrrrpgtplrlegiGEL--SAVVNVAVRDAEGKN----DEE----ILALIKPWVQNSKAD----- 1222
gi 223995593  1191 ------------------------sprceTGP--ANVLSVYIL---QADagvdQNS----MANKLELLLARNLES----- 1232
gi 219130617  1217 ---------------------------sgSDP--VNVLYFIVL---NSDigldEAShq-eIAKKCELILQGSHAL----- 1258
gi 301093012  1235 ------------------------tlsvrKDPl-VNVLHVILV-----DehseESK----LLEQAEAYLKSVDVD----- 1275
gi 855308001  1333 --------------------------sggESS--TNAIHIV--LSRVPDcmerDDK-----IKVFEEILEQYRSE----- 1372
gi 168041186  1143 kssaashhn----iiagsprrnrsfvgapSGF--GNVLHIALVGINNPMsafqDSGdedqINERVEKLAKALKGEslgam 1216
gi 685342799  1163 ----------------------------agaplsGNMMHIAIVGINNQMsllqDSGdedqAQERVDKLAKILKEEeviss 1214
gi 302811970  1149 ------------------------etkdsNHTrlGNVLHIALVGRKNQLsahqDSGdegqTQERVEKLAKGLKGEtlrgl 1204
gi 1028569116 1233 ------------------------temdnRSI--SDVWNIAIRDDSGSYt---DKE----IHGILHTTIAKCHAE----- 1274
gi 465795804  1173 --------------------------ntdADP--VNVLTIA----TPHEkpldDGA----FPTHIGDVLTELAPA----- 1211
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5I6I_A        1223 LLARRVRRLTFIC--GR-Nd--------GSYPSYYTFRGp----D--YAEDDSIRHIEPSLAFQLELGRLS-KFKLTPVF 1284
gi 223995593  1233 LEKADVRRVSFMI-----PnaesgsdnqFSLPSVFTFREt---aA--FKEDHLYRDIEPEVSHHLEMLRLTkNFSVSCLG 1302
gi 219130617  1259 LEQAGVRGVTFVMnqhyd------efeeYRAPAMFTFRFp------aYKEIALYRGIDPVRAPQLDLNRVAaNFDIRGLG 1326
gi 301093012  1276 LRAHNIRRVTFSVrpQNiEdisvhnadmALYPNIYTFPGr---mN--YSEDKILRHMEAPLAYKLELRRLQ-NYSVTPLA 1349
gi 855308001  1373 LITAGVSRVTITQ-----SpcsstmenrWELPTSFTFRNr---lG--FKEDPLVRHIEPPLAYHLELHRLR-NFTIRLVP 1441
gi 168041186  1217 LQVSGVGVVSCII--QRdE---------GRAPTRHCFQWshehhY--FAEEPLLRHVEPPLSNLLELVKLKgFAGMQYAP 1283
gi 685342799  1215 LCSAGVGVISCII--QRdE---------GRTPMRHSFHWsmekhY--YAEEPLMRHLEPPLSIYLELDKLKgYSNIQYTP 1281
gi 302811970  1205 LQAAGVGVVSCII--QRdE---------GRGPIRHCFHWsqetkS--YAEDPLYRHVEAPLSGFLELDNLKeLGTMKYSL 1271
gi 1028569116 1275 LRQSFVRRITIMV--VRf----------GQFPRYFTFKAt---rN--YFEDALLRHIEPAMAYQLEFESLQ-NFDVKPCF 1336
gi 465795804  1212 LAQAGLRRVSIML--CT-N---------GMYPLFATYRCl---rDgsWQEHRAIRNVEPALSYQLELDRIQpHFEITPLP 1276
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5I6I_A        1285 TQNK---NIHVYEAVGRgv--------eTDR--RYFTRAVVRPGRLRDEI-STAEY-------------LISEA-DRVVN 1336
gi 223995593  1303 AHLSptgQIYLYKATPKssalaqdkkanKSS--RIFARAVSFVSD------------------------FSAGTfERLLI 1356
gi 219130617  1327 SHNSatgQAHLYEAVPKkaalasdhkasKAA--RVFVRSLGFVTD------------------------MNQTSfDRILV 1380
gi 301093012  1350 SENK---NVHLYLAKMKdsda----hiiTDRfqRIFVRAVVRQLDHDGSG-SRSQY-------------DAYPGpERSLV 1408
gi 855308001  1442 IPNR---NIHLYEATPKeaavvrgsklpIRK--RFFVRAVCTTLDPLDTDtITDTY----------------PSaEKTLV 1500
gi 168041186  1284 SRNR---QWYIYNATEGkt---------rTR--RMFLRALIRQPKVndesvge----------dtrgitLVKDSiTQSLQ 1339
gi 685342799  1282 SRDR---QWHLYTVTDKsm---------pIK--RMFLRSLVRQATMNDGF-MLQQGqdkqlsqtlfsmpFTSRCvLRSLM 1346
gi 302811970  1272 SRDR---QWHLYSVQEKkg-------ksTVK--RTFLRTFVRQTKTLDED-------------------GTFESvIKALQ 1320
gi 1028569116 1337 VDNR---RLHIYYGVGKkn--------tSDV--RFFIRAIMYPGHILSNM-RTHDF-------------LVSEG-NRILT 1388
gi 465795804  1277 MSSS---SVHLYHARGLdn--------pADV--RFFVRALVRPQRAPSDV---PLY-------------LLSES-ERVLT 1326
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5I6I_A        1337 DIFDALEI--------IGTNKTDL----NHMFINFSH--TFQV-TA-------------------DEVAESLQGFLDRFG 1382
gi 223995593  1357 ESFNAIDSi-------KTAVPVGD----NHLFLNIASd-SCAViDP-------------------VDVEQVVGAILKRHG 1405
gi 219130617  1381 DTLNAFDL--------CSVKSRMD----NHVFINVASdfEKTVlDP-------------------VTVEHVVAGILKKHG 1429
gi 301093012  1409 DALNALEVnlsnplvkKSSLPTKN----NHVYLNILP--QAIV-DP-------------------QYLEGVIRILAYRYA 1462
gi 855308001  1501 EALNALDVgl----geARLRGDDKlfagNHIFLNILP--PAEL-DP-------------------NLIEQIMKNLYLRYV 1554
gi 168041186  1340 GALDELELav----hdT-NGKADH----IHLYLCILR--AQELdDLryhgqsfskfatdevekvvHALEGLAHEVYSKLR 1408
gi 685342799  1347 DAMEELELna----hnA-AMKPDH----AHMFLCILR--EQQIdDLvpyprrvevnaedeettieVILEEAAREIHRSVG 1415
gi 302811970  1321 GALEELEV---------AEGRAEH----VHMYLCVLR--PQGVrSLass--------------ivMWLEALVHKIYAALG 1371
gi 1028569116 1389 DVLDALELl------sATHPNTDC----NHLFLNIIP--TFQL-DL-------------------DEMESSLRSFVERHG 1436
gi 465795804  1327 EVFNTLEVaq----grKEYSSADG----SHIFLSWLY--PLDV-PL-------------------ERVMETCRQFEAQYA 1376
                          890       900       910       920       930       940
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
5I6I_A        1383 PRGWRLRVHQVEIRINCMrsdNNDENDTM-PLRVIITNTSGFVIQIELYEEKLSEK-GEWVYYYVS 1446
gi 223995593  1406 ERASRIGLAEIEAKVVCR---LADDSHPI-SLRLVASNPTGFVQVLNTYVEAADGSgQKRVFKSIG 1467
gi 219130617  1430 ERITTMGIVEVEIRIVCR---LSSESHPI-ALRLVSSNPTGYVHVMSTYVEAADDSsDERKFKLIg 1491
gi 301093012  1463 ERLEQLGVSTVELKIIAR---FNSEAPAI-PVRLVAENPTGYVVRVQAYVEAAGHD--EPIFTSIg 1522
gi 855308001  1555 RRLMALHVTQVEMRLLPI---LTHGAQPI-PVRMVGADPTGMALRIDTYVETKDNFtGSVIFTSIn 1616
gi 168041186  1409 ARMHRLAIAGWEIRVRLK-----ELQAANgAWRVVVSNPTGHTCIIQVYREAQDKDtGKVVYCSPf 1469
gi 685342799  1416 VRMHRLGVCEWEVRLWLV-----SSGLASgAWRVVVANVTGRTCTVNIYREVETSGrNSLIYHSit 1476
gi 302811970  1372 TRMYRLAVLAWELRMSLG---------GEgIWRVVVSNATGYTCKVEIYREVRDPLtKQTVYSSpf 1428
gi 1028569116 1437 KRLFKLRVTTAEVRFLRK---IPGSDIIQ-PVRFVVSSHSGYVMQVQAYQEVLDVT-GFKKLVSLl 1497
gi 465795804  1377 DHFRRLRIDDAEIRLILI-----NQGLQR-PLRIFVTTETAFTVSFTAYDEVIDVN-GAAVLRALs 1435
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