Conserved Protein Domain Family
AHSA1

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pfam08327: AHSA1 
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Activator of Hsp90 ATPase homolog 1-like protein
This family includes eukaryotic, prokaryotic and archaeal proteins that bear similarity to a C-terminal region of human activator of 90 kDa heat shock protein ATPase homolog 1 (AHSA1/p38). This protein is known to interact with the middle domain of Hsp90, and stimulate its ATPase activity. It is probably a general upregulator of Hsp90 function, particularly contributing to its efficiency in conditions of increased stress. p38 is also known to interact with the cytoplasmic domain of the VSV G protein, and may thus be involved in protein transport. It has also been reported as being underexpressed in Down's syndrome. This region is found repeated in two members of this family.
Statistics
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PSSM-Id: 311986
View PSSM: pfam08327
Aligned: 93 rows
Threshold Bit Score: 61.1904
Threshold Setting Gi: 81375095
Created: 19-Jul-2016
Updated: 4-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3Q63_D        18 SHPPEKLWRALTQPHLIEEW----LXKNDF-KPavGHRFNIsa--dWGGVLDCE----VLAVEPNKTLSYTWNLA--HQD 84
gi 81464845   13 DYPLMRVWNAVTVNEELIHWla-dKVTGRP-KE--GANFAWtwrlgMEGDLTTNg--iYKKIIPFKELILLWQDH----P 82
gi 74687776  209 QASADDLWGLLTDENKIPMWsr-sAAKLSL-KA--GSPYEL---------FGGNvrgkVITADPPKKLVQTWQVKspSWP 275
gi 48474991  215 DAPANELYATFLDPARVAAWsr-aPPQLDV-RP--QGAFSL---------FHGNvvgkFLVLEENKKIVQTWRLS--SWP 279
gi 74613616  201 RTSADELYATFTDPGRLAAFtr-aPPKVFE-GAkpGGKFVL---------FDGNvsgeYVELQEPTKIVQKWRLE--QWP 267
1X53_A        20 LTSPEELYRVFTTQELVQAFth-aPATLEA-DR--GGKFHM---------VDGNvsgeFTDLVPEKHIVMKWRFK--SWP 84
gi 166198354 209 DTTVEQLYSIFTVKELVQKFsk-sPAVLEA-ER--GGKFQM---------FDGNisgeYVELVTNRKIIMKWRCR--NWP 273
gi 82078528  194 LTSPEELYRIFITQEMVQAFth-lAAFVDG-RC--GGKFRL---------LEGNvhgqFAELIPDKKIAMRWRFA--SWP 258
gi 268559430 220 KATPERVFEAITETQLVRGWtngsIQEWDF-KE--GGKFAL---------FGGNvtgtFEKIEPSKEIVKKWRLK--KYP 285
gi 259484936 202 rTTAEELFKTFTEPERLAAFtrgqPRQWDGaKV--GGKYSI---------FDGNvtgeFVKLESPTLLVQKWRLA--QWP 268
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
3Q63_D        85 PafdlRSVVTFTLTP--TPTG--THLRXEQSGFRPDQRRAYGg--AKXGWPQFFe-KLEQLLD 140
gi 81464845   83 a---gEIELKLEFHSl-GEDS--SKLVVTNSGYPVGDKYDVWieaASEGWEEEGk-HLREYLK 138
gi 74687776  276 Se--hYGTMTLSLSQ--GSDT--TAATFTLDGVPAGTQAD-----VEKALNSFYiqGLKQ-MG 326
gi 48474991  280 Tg--hYAEITFTFDQ--ADSY--TTLRMIMKGVPIGEEEV-----VQGNIQDYYirPIKTVFG 331
gi 74613616  268 Qg--hYSTLKIEFDQ--NDVDkvTVMRVEWTGVPVGQEEI-----VKNNWNEYYvrSIKRTFG 321
1X53_A        85 Eg--hFATITLTFID--KNGE--TELCMEGRGIPAPEEER-----TRQGWQRYYfeGIKQTFG 136
gi 166198354 274 Ee--hYATVELNFVP--APGQ--TELQLDCKGVPVCKEEN-----MKFCWQKQHfeEIKGLLE 325
gi 82078528  259 Ag--hAATVILNFVN--QGSE--TELILEAKGVPSNEEER-----MKEGWQRYYfnAIKQTFG 310
gi 268559430 286 Nn--hHATIHFTLKD--NGSG--TDIKITAKEVPTHLADE-----TQTGLDRYYltSIARTFG 337
gi 259484936 269 Eg--hFSTLEINFDQndVDGV--TQMRVSWAGVPVGQEDV-----TKQNWELYYvrSIKQTFg 322
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