3GZH,3BHG,4MX2,2QGA,4EFC


Conserved Protein Domain Family
ASL_C

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pfam08328: ASL_C 
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Adenylosuccinate lyase C-terminal
This domain is found at the C-terminus of adenylosuccinate lyase(ASL; PurB in E. coli). It has been identified in bacteria, eukaryotes and archaea and is found together with the lyase domain pfam00206. ASL catalyzes the cleavage of succinylaminoimidazole carboxamide ribotide to aminoimidazole carboxamide ribotide and fumarate and the cleavage of adenylosuccinate to adenylate and fumarate.
Statistics
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PSSM-Id: 337004
View PSSM: pfam08328
Aligned: 241 rows
Threshold Bit Score: 105.962
Threshold Setting Gi: 609234967
Created: 27-Mar-2017
Updated: 23-May-2017
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3GZH_A        357 SRWQRDLTDSTVLRNLGVGIGYALIAYQSTLKGVSKLEVNRDHLLDELDHN-WEVLAEPIQTVMR------RYGIEKPYE 429
gi 74951240   277 SRMQRDLSDSSVLRNLGVAFAHSVVAYNSILSSLERMYFDESTSKLEIQEN-WNILSEPVQLNLK------MMGHMDAFE 349
gi 294944105   34 SRMQRDLTDSTVQRAVGSAFAHTIIAIDSTIKGLSKVMVSAPIANRELEDH-WAVTGEAVQTVMR------RYGLERPYE 106
gi 401406536  261 SRMQRDLSDSTVLRNVGVAFGHCLVAYESTKKGLGRVDVNRAAMLRELENH-WAVLGEPMQTVLR------KRGVRNAYE 333
gi 257780667  328 SRMQRDLSDSSAQRNIGAAIAYSYIAINSTLRGFRKISINPKTIEDDFEEA-WEVIAEAVQTVMR------KHGYCNPYE 400
gi 1052737609 333 SRMQRDLSDSSSQRNIGLAFGYSLQAISETTNGLAKCVVNKDKLAADLNEK-WEVLAEPIQTMLR------KYGISDAYD 405
gi 156087609  336 SRMQRDLSDSTVLRNVGVAFCHSYLAYLSILKAFSRISVNESRALEELDAN-WVVLSEPLQIHLR------MTGDASGYE 408
gi 609234967  324 SEHQRDLSNSASGRFTVEILAGFAAAVKRMVKILSGMTVNMKGLQRNLENAgSSVLAEPAYILLS------SQGEADAHE 397
gi 503102441  322 SRLQRDLSDSTIKRNIGLGIGHVILGVRRLNTVLSSINVNEDAISRDLNEH-WEVLSEAVQVRLR------ALGMADAYE 394
gi 81437636   328 SRLQRDLSDSSVQRNIGVALGHSLVAIDNLKRGLAGIRLNKNRLTEDLNNN-WEVIAEAVQTTIRaeilacKSNEANPYE 406
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
3GZH_A        430 KLKELTRGKRVDAEGMKQFIDGL--A-LPEEEK--ARLKAMTPANYI 471
gi 74951240   350 KVLVFTRGFNPSKDEMLKFIEEN----CGKD----SRLLTLKLEEYl 388
gi 294944105  107 RLKEFTRGREIDATSMKEFTENIgrE-IGEDKPgvKGLENLTPQTYI 152
gi 401406536  334 KLKSATRGQAIDKERMQDIVEACgaDlLPEDV---DALRSLTPATYT 377
gi 257780667  401 RLKEITRGKMIGKEEIRAFISSV--E-LPEEDK--MRLMELSPQKYI 442
gi 1052737609 406 QLKELTRGKNISQEAIMEFAKGL--DvLSDEDR--QTLLDMTPASYI 448
gi 156087609  409 KMLSLTRTGCVSKETMKDIISDNcgN------N--TDLKSLTPSKYI 447
gi 609234967  398 IIRKFTLKAEQEEKSLSEVMKSD--KaVWEKIS--RRLEAvgvdnpd 440
gi 503102441  395 RALAIFRGSRMGMEDYKKALGEL--G-VNDD-----ILRGLSPDKYV 433
gi 81437636   407 RLKDFTRNKKITKHTLDEFITNL--D-LSEHAK--KRLLELTPSKYT 448
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