Conserved Protein Domain Family
RTX_C

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pfam08339: RTX_C 
RTX C-terminal domain
This family describes the C-terminal region of various bacterial haemolysins and leukotoxins, which belong to the RTX family of toxins. These are produced by various Gram negative bacteria, such as E. coli and Actinobacillus pleuropneumoniae. RTX toxins may interact with lipopolysaccharide (LPS) to functionally impair and eventually kill leukocytes. This region is found in association with the RTX N-terminal domain (pfam02382) and multiple hemolysin-type calcium-binding repeats (pfam00353).
Statistics
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PSSM-Id: 311996
View PSSM: pfam08339
Aligned: 4 rows
Threshold Bit Score: 155.671
Threshold Setting Gi: 1710794
Created: 23-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1008976759  346 SLANINLKEVSFERNGNDLLLKTN-----------NRTAVTFKGWFNKpnssaglNEYQRKLLEYAPEKDRarlkrqfel 414
gi 1043914202  810 AFSDVNLKDLTFKKVDSSLEIINQ-----------KGEKVRIGNWFLE-------DDLASTVANYKATNDR--------- 862
gi 1710794     869 lLSDLSFKDVGFIRIGDDLLVNKRiggtlyyhedyNGNALTIKDWFKEgkeg---------------------------- 920
gi 150513      807 SFSDSNLKDLTFEKVKHNLVITNS-----------KKEKVTIQNWFRE-------ADFAKEVPNYKATKDE--------- 859
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1008976759  415 qrgkvdkslnnKVEEIIGKDGERITSQDIDNLLDKSGNKktISPQELAGLIKNkgkssslmsssrsSSMLTQKSGLSNDI 494
gi 1043914202  863 -----------KIEEIIGKGGERITSEQVDKLIKEGNNQ--ISAEALSKVVND-------------YNTSKDRQNVSNSL 916
gi 1710794     921 --------qnnKIEKIVDKDGAYVLSQYLTELTAPGRG------------INYfngleeklyygegYNALPQ---LRKDI 977
gi 150513      860 -----------KIEEIIGQNGERITSKQVDDLIAKGNGK--ITQDELSKVVDN-------------YELLKHSKNVTNSL 913
                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....
gi 1008976759  495 SRMISAtsgfgssgK----------ALSASPLQTNNNFNSYANS 528
gi 1043914202  917 AKLISS--------V----------GSFTSSSDFRNNLGTYVPS 942
gi 1710794     978 EQIISStgaltgehGqvlvgaggplAYSNSPNSIPNAFSNYLtq 1021
gi 150513      914 DKLISSvsaf------------------tssnDSRNVL--VAPT 937
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