Conserved Protein Domain Family
FAST_2

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pfam08368: FAST_2 
FAST kinase-like protein, subdomain 2
This family represents a conserved region of eukaryotic Fas-activated serine/threonine (FAST) kinases (EC:2.7.1.-) that contains several conserved leucine residues. FAST kinase is rapidly activated during Fas-mediated apoptosis, when it phosphorylates TIA-1, a nuclear RNA-binding protein that has been implicated as an effector of apoptosis. Note that many family members are hypothetical proteins. This subdomain is often found associated with the FAST kinase-like protein, subdomain 2.
Statistics
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PSSM-Id: 337026
View PSSM: pfam08368
Aligned: 87 rows
Threshold Bit Score: 65.6443
Threshold Setting Gi: 597734413
Created: 27-Mar-2017
Updated: 23-May-2017
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122064189  285 LLNMAAAAKRVPGAKESLLATHRAELF---VPFEPSKDKR--VLVTGMLDALKSLIPS-E-S-MVKISQTTTMGFTIDAE 356
gi 334342438  449 LVHINATAQLEHPKYIGPYLPLATCQQafrLQTSTSRKMT--PMQKDLQDIMKGWLGS-E-D-KVRFGETTQYGWELDAE 523
gi 1043417833 100 LAHINATALLEHPEYTGPHLPNESISTthaVTANR--KLS--PLQSGLQEVLRELFPV-E-G-TCRCGVNTVYGWYIDGE 172
gi 483505625  319 LLHINATARLEIPEYQGPFLTPNLl----gTVGSAGEGGS--QLQGSLREALTGVLGD-Q-D-RARFDAPTIYGWQIDAE 389
gi 942196748  291 LIHINSTARLETAEYKGPYLPDSFli---sQRLQGEKSAS--SLQIGLREALKSAIGD-E-A-KYRCGIDTVYGWNLGGE 362
gi 348526914  460 LLHIAATLSLEHPG----SLDTLPSQSvlsVPASSSPL-S--PLQRTLRETLLKFVGG-K-SeALRTGVDTVYGWSIDGE 530
gi 195998900  463 LYQIDLATILESGDSSIQCLSPVNKRKfvqAFCAVTTSLS--SLEQNVVPAIHQFVGG-D-R-YYRLQVATPFGYSIDIE 537
gi 765145230  458 LLHIAASLHLENP---GSSAGPVSSPSilpVPANASPL-S--VLQRSLRETLQSLVGG-KtE-VLRVGVNTVYGWTIEGE 529
gi 597734413  455 LTQIAASGQLE-------SIGASSVLPtihIPALQGKAPTttPLQSSLSTALQNLTRSfP-N-SLRTDVNTVFGWTVDAE 525
gi 733891549  458 LIQINAAAKLESPEYQGPFLPAGMLSAa----EPAAEKVT--LLQSSLREALAGVLGS-Q-D-NGRWDVHTIYGWQIDAE 528
                          90
                  ....*....|
gi 122064189  357 CVLDKKCLPL 366
gi 334342438  524 LVLDVENQPL 533
gi 1043417833 173 VVLDSDNKPL 182
gi 483505625  390 VVVNAENKPL 399
gi 942196748  363 VLLDVDSKPL 372
gi 348526914  531 LIVDADNKPV 540
gi 195998900  538 LLLDKDKNLM 547
gi 765145230  530 MVVDCENKPV 539
gi 597734413  526 LVVDSENKPI 535
gi 733891549  529 VVLNSENKPL 538
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