Conserved Protein Domain Family
Dynein_IC2
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pfam11540: Dynein_IC2 
Cytoplasmic dynein 1 intermediate chain 2
Intermediate chain IC 2 forms part of the complex cytoplasmic dynein 1 along with a heavy chain (HC), two light intermediate chains (LICs) and three light chains (LCs). The complex is responsible for hydrolysing ATP to generate force toward the minus end of microtubules. IC binds to the HC via the N terminal binding domain on the HC and ICs contain binding sites for the LCs. The ICs are responsible for binding to kinetochores and the Golgi apparatus through an interaction with the p150Glued subunit of dynactin which is another complex.
Links
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Statistics
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PSSM-Id: 463291
Aligned: 18 rows
Threshold Bit Score: 52.9364
Created: 24-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_004359310  99 KYKPTLSIQNlVIEFDIPPREIPTYTKATQTP 130
EDX18442     105 KQPLNLSVYN-VQATNIPPKETLVYTKQTQTT 135
XP_012550157 106 KQPQELQVVF-VQSTDIPPKETVIYTKQTQTT 136
XP_975764    105 KRAPNLSVVQ-VQSTNIPPKETVLYTKQTQTT 135
EFX81426      48 RKKPQLTKVS-VQATDIPPKETVTYAKQTQTV 78 
ETN64513     101 KKPVNLCLVS-VQATNIPPKETVSYSKQTQTN 131
XP_015794556 101 KKPISLALVN-VNEINIPPKESVTYNKQTQTT 131
EEN62938     106 RKSLKLSLTD-TSVINIPPREKVAYSKETQTI 136
EKC26112     102 RRKAKLTVTK-VGETNIPPRENVTYSKETQTI 132
P54703        96 YIRPTLTIQSlVIEHDFPPKEIPMYSKGTQTM 127 Dictyostelium discoideum
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