Conserved Protein Domain Family
N-SET

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pfam11764: N-SET 
COMPASS (Complex proteins associated with Set1p) component N
The n-SET or N-SET domain is a component of the COMPASS complex, associated with SET1, conserved in yeasts and in other eukaryotes up to humans. The COMPASS complex functions to methylate the fourth lysine of Histone 3 and for the silencing of genes close to the telomeres of chromosomes. This domain promotes trimethylation in conjunction with an RRM domain and is necessary for binding of the Spp1 component of COMPASS into the complex.
Statistics
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PSSM-Id: 463344
Aligned: 69 rows
Threshold Bit Score: 132.796
Created: 24-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_003668713  771 KKSIDILDFQEVIKDTEDISILQELLDAnetkPTEEMKHAGCISEYAIWKYRENEKNL-------RLTNEWH--LN---- 837 
Q7QKB2         15 GILFDF--LTRGV-DAEDVRYIRQSYDMl---LMDDASSYWLNATHWVDHCATDRNFEpa---llAPPPSKRrkKD---- 81   Anopheles gam...
ETN58655     1778 MVLYDF--LTRGI-DTEDTQYIRQSYDLl---LMDDANNYWLNATHWVDHCATDRSFEpalhqalGGPSAAK--RRkkdk 1849
2_pfamImport    1 GILYKI--WEAGL-DVEDMKHLRHVYEEm---LATPGEMGWVNDTHWVPHPTTHIPTDddv-tglSPTKRGRrkRRqskk 73  
XP_026690140 1606 RMMYNI--WDRGL-DVEDMKYLRQEYEDm---LANPGTGGWVNDTHWVPHPATYFPDEnda--ltTSPDKRNkrKR---- 1673
XP_007255045 1561 TILYDI--WNDGI-DEEDIKYLKITYDKl---LQQDNVNDWLNDTLWVHHPTTSGGSL---------PGLKK--KR---- 1619
XP_012809768 1451 TILYDI--WNTGL-DFEDMVFLRDTYERl---LQEDHSTDWLNDTHWVHHPITNIADP-----------KRR--KN---- 1507
XP_005469029 1920 TILYDI--WNSGL-DGEDLLFLKKTYEKl---LQDDHSSDWLNDTHWVNHTITNLPNP----------RRKK--KN---- 1977
Q6FKB1        785 IDTVSLFDLQDAIKDEEDMEFLKECLPAg---EDLEFDDDNGLLEYRIWKIKQMADIS-------QSSTNNE--LR---- 848  [Candida] gla...
Q6CIT4        678 SKQLSLDKFQLALKDEEDFSILKGIVSEk---SKDITTDYTPFLPYSMWKLYQQIEQN-------GIIRDNQ--IA---- 741  Kluyveromyces...
XP_003668713  838 -LNev---pfDVELTKGKGSFKAEGFRKIPDNLKACYL-PHRRKLNQPLNTVNQHGSDRPTGNKFTPEpsarreesndPD 912 
Q7QKB2         82 -KGgaggsslADIKLHRTGCARTEGYYKIDPREKAKYK-YHHLKGTVAANHLT-------------------------NL 134  Anopheles gam...
ETN58655     1850 fIDrs----lADIKLHRTGCARTEGYYKIDALEKAKYK-YHHLKGMTTT----AAGTSSGAAANL--------------- 1905
2_pfamImport   74 dVA-------ADPHAHKTGCARSEGYYKVNDSTKLI---QRRLMYRQADNTPQPRSKSKYSNE---------------SS 128 
XP_026690140 1674 -RQark-ddiSDIKPHKTGCARSEGFYKVNDNTKL---------IQRKLMYRQADNTPQPKGRSKY------------AN 1730
XP_007255045 1620 -RE-------DGMRDHVTGCARSEGYYKIDKKDKLKYLiSSRPQFDEPDKDTQ-------------------------GK 1666
XP_012809768 1508 -RQ-------DGLREHQTGCARSEGYYAISKKDKDKYL-----KVLLVAAEEQ--------------------------- 1547
XP_005469029 1978 -TD-------GQLREHVTGCARSEGYYAISRKEKDVYL-----DLDLPEQVIR--------------------------E 2018
Q6FKB1        849 -LNnq---tlDKTLFEKNIPFIASEFKHIPEKLKSSYL-PHKRRVHEPLNTVSHHNESKEQSPDIAIKeks-----vnKA 918  [Candida] gla...
Q6CIT4        742 -LNek---efDSTLASTTGSFIADGFKKIPDKLKSSYL-LHHRRLAQPLNTVHNHQEQNFMALNGTESt---------NQ 807  Kluyveromyces...
XP_003668713  913 ASESVSIQeiSSSRDNRASNRRFQQNIEAQRAAIGAESDLLSLNQ 957 
Q7QKB2        135 ELAKAVAKmqGISREARSNQRRLLNAFGA-----STESELLKFNQ 174  Anopheles gambiae str. PEST
ETN58655     1906 ELAKAVAKmqGISREARSNQRRLLNAFGA-----STESELLKFNQ 1945
2_pfamImport  129 STSVVANE---KSRETRHMMRRIASEFG------SDASDLLKYNQ 164 
XP_026690140 1731 ESASTSGVatEKSRETRHMMRRIASEFG------SDASDLLKYNQ 1769
XP_007255045 1667 SIPAQPHAstRAGSERRSEQRRLLSSF-------SCDSDLLKFNQ 1704
XP_012809768 1548 EADTQGTN--RVLSERRSEQRRLLSAMGSTA---LLDSDLLKLNQ 1587
XP_005469029 2019 VENVDTSGanRVLSERRSEQRRLLTVIGTTA---VMDSDLLKLNQ 2060
Q6FKB1        919 DTGEGSLAeiSSSRDNRASNRRFQQNIEAQKAATGTESELLSLNQ 963  [Candida] glabrata CBS 138
Q6CIT4        808 EADLEQDNhnASSRLNRVFQRRFQQDIEAQRAAIGFESDLLSLNQ 852  Kluyveromyces lactis NRRL Y-1140
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