4XYH


Conserved Protein Domain Family
CAF1C_H4-bd

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pfam12265: CAF1C_H4-bd 
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Histone-binding protein RBBP4 or subunit C of CAF1 complex
The CAF-1 complex is a conserved heterotrimeric protein complex that promotes histone H3 and H4 deposition onto newly synthesized DNA during replication or DNA repair; specifically it facilitates replication-dependent nucleosome assembly with the major histone H3 (H3.1). This domain is an alpha helix which sits just upstream of the WD40 seven-bladed beta-propeller in the human RbAp46 protein. RbAp46 folds into the beta-propeller and binds histone H4 in a groove formed between this N-terminal helix and an extended loop inserted into blade six.
Statistics
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PSSM-Id: 463513
Aligned: 228 rows
Threshold Bit Score: 36.7879
Created: 24-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4XYH_A        28 EEYKLWKQNVPFLYDLVITEALEWPSLTVEw-----------FPGsErSLADNSSiqkLLL-GTQTSG----------ND 85  Schizosaccharom...
EGR27180       5 EKQQKWKLYNPYLYDYILDNNLDWPCTTCQw-----------GPv--iQQNSQYIkqnIFF-ACRTDGtyieqenswqKQ 70 
XP_012651772   5 DKQQKWKLYQSYIYDYVLDNNLDWPCTTCSw-----------GPi--iSENSELLkqrVYF-ACRTDGiyneadttwqKL 70 
EFN58798       6 QQHVAWRKLVPYLYDWFASHSLFWPSLACRw-----------GPv--lERGPQSNkqrLYL-SEQTDG----------SE 61 
XP_002282044  54 DSYSRWKNVVPVIYDWLANHNLVWPSLSCRw-----------GPq--fEHGNHKNrqrLYL-SEQTDG----------TV 109
XP_009128524  60 KKYSQWKTLVPILYDSLSNQSLVWPCLSCRw-----------GPq--iEQALAKNqqrLYL-TEQTNG----------SV 115
EFH43650      57 DKYSQWKTLLPILYDSFVNHTLVWPSLSCRw-----------GPq--lEQAASKTq-rLYL-SEQTNG----------SV 111
XP_003058120   6 DSYGRWKNLVPFLYDWFAHHRLVWPSLSVRw-----------GAv--lETNEYKHkqrLYL-SEQTDGs--------pFF 63 
XP_002499704   6 EDYGRWKSLVPFLYDWLAHHRLVWPSLSCRw-----------GQi--lEQGDYKLkqrLYL-SEQTDGss-------pTF 64 
Q4DXX2       146 PQQLVYSNKA---YDSFFQLRTEYPSLSFDvlrdrdtanhskYPL-S---L-------TLVcGSQADE----------LS 201 Trypanosoma cruzi
4XYH_A        86 QNYLQVASVQLPT 98  Schizosaccharomyces japonicus yFS275
EGR27180      71 PSQLIVAQIDIPQ 83 
XP_012651772  71 PSFLVVAQVDIPQ 83 
EFN58798      62 PNRIVLVNVDVVH 74 
XP_002282044 110 PNTLVIANCEIVK 122
XP_009128524 116 PNTLVVATCEAVK 128
EFH43650     112 PNTLVIANCESVN 124
XP_003058120  64 PNTLVVANAEVIK 76 
XP_002499704  65 PNTLTVANVEVVK 77 
Q4DXX2       202 KNQLYVLRIQNIC 214 Trypanosoma cruzi
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