Conserved Protein Domain Family
LRR19-TM

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pfam15176: LRR19-TM 
Leucine-rich repeat family 19 TM domain
LRR19-TM is the single-span transmembrane region of LRRC19, a leucine-rich repeat protein family. LRRC19 functions as a transmembrane receptor inducing pro-inflammatory cytokines. This suggests its role in innate immunity. This family of proteins is found in eukaryotes.
Statistics
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PSSM-Id: 317577
View PSSM: pfam15176
Aligned: 12 rows
Threshold Bit Score: 151.826
Threshold Setting Gi: 612036419
Created: 28-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51701677   250 NLTWTSEHEPL-GKSWAFLVGVVATVLLTSLLIFIAIKCPVWYNILLSYNHHRLEEHE------AEtyengl-------t 315
gi 123892697  223 LTSPAPDTAKSnGRSWPYLVGFIVIAICLSLIIALAAKCNVFHRYLRSYRHRPLPENDwinqsqTE-------------- 288
gi 637294273  245 TSTSTPPLEKT-GRSWPYFAGFILLAAGISILIALVAKCILLRRNRASYQHQRLPDSRsvgsshAEeadmgv-------- 315
gi 612036419  257 NKTKNAESEPS-GKSWALLVGVVVVVTVTSMLIFIAIRCPTWYNFFFSYNHHRLDEQE------ADtyegdf-------t 322
gi 1025451988 256 CTVSKRQKPLS-GHTWKFTACIAALGLTTCILILTAIKGPSWYKSFHNYRHRRLVEDDeeegqdTMptetggc-----es 329
gi 344271087  256 nLTRNPEHERF-GKSWAFLVGVAVSVLMTSLLIFIAIKCPLWYSFVLSYNHHRLEEHE------AEtyedgc-------t 321
gi 565322721  152 AANTTPATQTA-GKNWIYFAGFVLLAITISLLIALIVKCKLLQKKHASYHHQRLPDSRsigschIEerdmdm-------- 222
gi 971409532  185 nnTTVPPVGKG-GRSWPYLVGFLVAAISISILVALVAKCKLCHKNFTSYRHRPLPETGsiggspLEegtgwdrgssgwgd 263
gi 525005125  247 nntTALPAVKG-GRSWPYLVGFIVTAIGISILIALAAKCKLAHKNFASYRHRPLPEISsiggspMEdtssw--------- 316
gi 345777496  256 NL-KNSERKLL-GKSWALLVGVVVTVLMTSLLIFVAIKCPIWYNFLLSYHHHRLEEHE------AEtyedgf-------t 320
gi 395819002  256 NLTRDSEHGPL-GKSWAFLVGVVVTVLMTSFLIFIAIKCPIWYNILLSYNHHRLEEHE------VEtynesf-------n 321
gi 532097178  256 NFTRNSEHEPL-GKSWVFLVGVVVTALMTSLLILTAIKCPIWYNFLLSYNHRRLEEHE------AEtyedgf-------p 321
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 51701677   316 rnpssLSQITDTNSEdttvifeqlhafvvD-DDGFIEDRYIDINEVHEEK 364
gi 123892697  289 -----LPGVPLPPNE--------------D-EDGFIEDNYIQPEDHHEEE 318
gi 637294273  316 -aygrnPPGAGCPAd--------------D-DDGFIEDNYIEPNRDMRee 349
gi 612036419  323 vypnsLPQTPDTNPDdsivifdqlssfmvD-EDGFIEDKYIDTQEMREEN 371
gi 1025451988 330 qqtftFEELSHRIQEq-------------DeEDGYFEDPYIKRTEDSEEE 366
gi 344271087  322 gnpssLSPAPNTNSEettvifgqlpsfavD-DDGFIEDKYIDTHELHEEN 370
gi 565322721  223 -tygrnqPASECYPE--------------D-DDGFIEDNYIVPNQDLKEE 256
gi 971409532  264 senppVSSVTGLHVE--------------D-DDGFIEDNYIQPSEQLPEE 298
gi 525005125  317 -drgsIPDAADLQAE--------------D-DDGFIEDNYIQPSEQLPtk 350
gi 345777496  321 gnsssLSQVPDTNSEdttvifeqlhsfvvD-DDGFIEDKYIDTHELHEEN 369
gi 395819002  322 gnpssFSQISATNPEdttviferlhsfvvD-DDGFIEDKYIDTHELCEEN 370
gi 532097178  322 gnsnsLPHIGDINSEdttvifeqlhsfvaE-DDGFIEDKYIDTHELCEEN 370
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