3HHC


Conserved Protein Domain Family
IL28A

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pfam15177: IL28A 
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Interleukin-28A
The protein family, Interleukin-28A, plays an important role in modulating the immune system. This protein family is induced by viral infection and interacts with a class II receptor. This family of proteins is found in eukaryotes. Proteins in this family are typically between 145 and 195 amino acids in length.
Statistics
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PSSM-Id: 317578
View PSSM: pfam15177
Aligned: 29 rows
Threshold Bit Score: 138.588
Threshold Setting Gi: 487523167
Created: 29-Jul-2016
Updated: 4-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3HHC_D         34 ARGCHIAQFKSLSPQELQAFKRAKDAL-EESLLLKDCKCRSRLFPRTWDLRQLQVRERPVALEAELALTLKVLeatADTd 112
3_pfamImport    1 AKDCNIAQFKSLSPQELQAFRKAKDAI-EEGLLPKDVRRASRLLPRDGNLQQLQVQERQKALQAEVALTLKVLgnmTDP- 78
gi 408360147   32 AKDCHIAQFKSLSPKELQAFKKAKDAI-EKRLLEKDLRCSSHLFPRAWDLKQLQVQERPKALQAEVALTLKVWenmTDS- 109
gi 487523167   24 pRRCLLSHYRSLEPRTLAAAKALRDRYeEEALSWGQRNCS---FRPRRDPPRPSSCARLRHVARGIADAQAVLsglHRS- 99
25_pfamImport   1 RKGCRLSKYQNIAHEEQKAVDKMRLSL-GSCLQVNNHKCNTRLFHRKWNAVDLPMSDRVLLVAAELNLTMAMLelpAAP- 78
gi 677991589   28 KKSCSLSKYQFPAPLELKAVWRMKEQF-EDIMLLTNRKCNTRLFHRKWDIAELSVPDRITLVEAELDLTITVLtnpTTQ- 105
24_pfamImport   1 KKSCRLSQYGSPAYSELAEVLKFKKYY-ENIT-SKDSKCSTRLFNRKWTPNELSVPDRLLLVEAELDLTIAVLahpTVD- 77
2_pfamImport    1 RRHCHMSRYRSVSPSDIRAVRRLHNEH-EKSPFSDGIKCYRKMLRQKPSVCDLQASDRLILTLERVTLAVDVLtnmTES- 78
gi 821478789   23 ERSCQISQFKSLSPRELETFKVAKDAY-EKAMLQTERKCSSRFFHRNWDLRQLPVSVRPVVLQAELKLTLEVLkavTKP- 100
gi 612025825   44 EKSCQIPQFKSLSPREMEAFTMAKDTY-EKSMLQKKRKCSSKFFHRGWDFRQLQLADRPIVLEAELKLTLEVLkgiQNP- 121
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3HHC_D        113 pALGDVLDQPLHTLHHILSQLRACIQPQPTAGPR--TRG-RLHHWLHRLQEAPKKESP---GCLEASVTFNLFRLLTRDL 186
3_pfamImport   79 -ALVTILGQPLHTLSHIHSQLQTCTEPQPTAEPT--PQSrLLSRWLHRLQEAQNKETP---GCLKAYVTLNLFRLLTRDL 152
gi 408360147  110 -ALATILGQPLHTLSHIHSQLQTCTQLQATAEPR--SPSrRLSRWLHRLQEAQSKETP---GCLEASVTSNLFRLLTRDL 183
gi 487523167  100 -ELLPGAGPILELLAAAGRDVAACLELARPGSSRkvPGA-QKRR-----HKPRRADSP---RCRKASVVFNLLRLLTWEL 169
25_pfamImport  79 -SFAEVRRRPLEFFAQAREDVRGCVSACPSVDPAhqPSG-RLRHWLHKLQAAMRTESPestACLRATTILHVLQVL-GNL 155
gi 677991589  106 -RLAETCQQPLAFLTQVQEDLRDCLALE---APShqPSG-KLRHWLQKLKTAKKKETA---GCLEASAILHIFQVL-NDL 176
24_pfamImport  78 -KLAEKSQQPLAFFTQAREDLRGCVAAE---APShqPSG-KLRHWLQKLETAKKTETA---SCLEYSTIVHLFQVL-HDL 148
2_pfamImport   79 -PLAKLLSLPLTMLLSLEDDLKICRKSPLYSDP---PSE-QLMPWLHHLKHFREKVSS---ECVQDAVLLSLTQLLIEDI 150
gi 821478789  101 -ELDSVLAQPLQTLSHIHQEIQSCVTSQTSKEHK--LPG-RLKNWLNKLSEA-RKEPQ---NCLEASIMLNLFRLLTQDL 172
gi 612025825  122 -ELQDVLIQPLQTLSHIYREIQSCVTPLPSRGHR--LPG-RPNNWLHRLTEA-GKESQ---SCLEASVMLTLPRLPDTDL 193

                  ....*.
3HHC_D        187 NCVASG 192
3_pfamImport  153 KCVASG 158
gi 408360147  184 KCVANG 189
gi 487523167  170 RLAAHs 175
25_pfamImport 156 RCAAL- 160
gi 677991589  177 RCAAQR 182
24_pfamImport 149 GCVA-- 152
2_pfamImport  151 MCWANN 156
gi 821478789  173 RCVAYG 178
gi 612025825  194 Rfflsh 199
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