Conserved Protein Domain Family
NPBW

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pfam15180: NPBW 
Neuropeptides B and W
The function of this family, NPBW, which includes Neuropeptides B and W, is thought to be involved in activating G-protein coupled receptors, GPR7 and GPR8. It is thought to play a regulatory role in the organisation of neuroendocrine signals accessing the anterior pituitary gland. It is predicted that this effect will stimulate the increase in water-drinking and food-intake. This suggests it plays a role in the hypothalamic response to stress. This family of proteins is found in eukaryotes.
Statistics
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PSSM-Id: 317580
View PSSM: pfam15180
Aligned: 21 rows
Threshold Bit Score: 97.4588
Threshold Setting Gi: 33301336
Created: 29-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33301336   26 LPLLLLLLLLPLPASAWYKHVASPRYHTVGRASGLLMGLRR-SPYLWRRALGGAAGPL--VG------------------ 84
gi 301615810  18 FCSALALLLSCQRTHAWYKQSTGPSYYSVGRASGLLSGIRR-SPDIRRSEPENSMESTeiPE------------------ 78
gi 768917969  47 PAVSLLLLLACSPAEAWYKQVAGPRYYSVGRASGLLSGIRR-SPYTKRAEPEPTDGES--AG------------------ 105
gi 973136355  13 VVAAISMLISCHPTAAWYKQATGPSYYSVGRASGLLSGIRR-SPYIRRSEP-EAMAES--GEstgnfmt-----emgsqa 83
gi 188219655  10 VFVAVSILISSHPTDAWYKQSTGPSYYSVGRASGLLSGIRR-SPYVRRSEG-ESALDS--GEtpgvsnsvlaelsssnsg 85
gi 348525320  10 PIVVISVLVACSPTEAWYKQVAGPTYYSVGRASGLLSGIRR-SAYVRREEP--HHADT--DEsatnnv-------fseip 77
gi 551499890  10 PIVAIFLLVACSPSEAWYKQVAGPNYYSVGRASGLLSGIRRsSSYARREE---SPSES--GEsatssv-------lsqfl 77
gi 926659856   9 PVLVVSLLAAGGPSEAWYKQAAGPSYYSVGRASGLLSGIRR-SPYVRRAEP--EPADS--DEpadena-------faqlt 76
gi 344248341  18 LLPLLLVLLLPLPAGAWYKHVASPRYHTVGRASGLLMGLRR-SPYLWRRALGGAVGPL--SRdt---------------- 78
gi 971425112   7 LALAVAVALLCRPAAPWYRQAAAPLSYPVGRASGLLSGLRL--PYSRRSDSEGAAERR--PPal---------------h 67
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 33301336   85 -Lp----------GQMARSA-LLLPSPGQELWEVR-----SRSSPAGLPVHatrslrdlegagqpeqsLSFQSWTSAE 145
gi 301615810  79 -EtylnslgvkrqGAVLKSMaLCVKDVSPNLHSCEllpdtSSTFQCKAQIY-----------------LSLDTSDCLA 138
gi 768917969 106 -Snaae---aslqNFILRTMpVCVKDVQADPQSCQllqdlRGLLRCQADVF-----------------FSLDPSDCAE 162
gi 973136355  84 rQ-----------TAFLKNMaVCVKDISPNLQSCElvqdgMSTFQCKADVY-----------------LSLDSQDCVN 133
gi 188219655  86 rQ-----------TPVLKNMaICVKDISPNLQSCEllqdgSSSFRCKADVF-----------------LSLDSLDCFT 135
gi 348525320  78 aS-----------SSILKTMpVCIKDITPNLQSCEriqdiKASFRCKADVF-----------------LSLDSSDCEa 127
gi 551499890  78 sH-----------NSVLKTMpLCIKDITPNLQSCElfqetKGSLKCKADVF-----------------LSLDSSDCEg 127
gi 926659856  77 aQ-----------NFILKTMpVCIKDISPDLQSCElq-eiTGSFKCKADIF-----------------LTLDSADCGg 125
gi 344248341  79 lVp----------GPVTGSTlPLLPSPVQELWETR-----RGSWRAGLPVYeprsprdlerarqpeqsLSLRSWISAE 141
gi 971425112  68 pGs----------AAPLRTAvPCVTDVDPELRSCRplsgvPGALQCRVAVT-----------------VSLVSTECAG 118
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