Conserved Protein Domain Family
HPIP

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pfam15226: HPIP 
HCF-1 beta-propeller-interacting protein family
HPIP is a small cellular polypeptide that binds to the beta-propeller domain of HCF-1. HPIP regulates HCF-1 activity by modulating its subcellular localization. HCF-1 is a cellular protein required by VP16 to activate the herpes simplex virus- immediate-early genes. VP16 is a component of the viral tegument and, after release into the cell, binds to HCF-1 and translocates to the nucleus to form a complex with the POU domain protein Oct-1 and a VP16-responsive DNA sequence. HPIP-mediated export may provide the pool of cytoplasmic HCF-1 required for import of virion-derived VP16 into the nucleus.
Statistics
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PSSM-Id: 317610
View PSSM: pfam15226
Aligned: 6 rows
Threshold Bit Score: 140.143
Threshold Setting Gi: 291413117
Created: 30-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351700234   2 ILQQPLERASPGLAL---RATSGVTRGLDTsspvrgavpmstkqrleeqiflslpREALRKQFLTEENMATHFSRLSLHN 78
gi 291413117   2 ILQKSLERGPLSRALrdpRAVSGTSRGLDA-------------------------REPVRKHSPSEESMATHFSRLSLHN 56
gi 568815696   2 ILQQPLQRGPQGGAQrlpRAALGVTWGLDArlppvsvsq--------paslpslpREPLRKQFLSEENMATHFSQLSLHN 73
gi 395835807   2 ILLQPSERGPQGRTQrrsQATLGVTRGPDAssplrgavlm------stkrrleeeQEPLHKQFLSEENMATHFSRLSLHN 75
gi 731503718  87 ILPQPLERGPRGRTQrdpSAASGATWSLDAssplqavpm--------stkrrlevQETLHKQFLSEENMATHFSQLRLHN 158
gi 928138008   2 ILQQPLERGPPGRAQrdpRAASGTPRAQDVssplrgavpm------stkrrleeeQEPLRKQFLSEENMATHFSRLSLHN 75
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 351700234  79 DHPYCSPPMPFLpalPPLRsPCSELFLWRYPGSLIPEALRLLRLGDTPTPHFAATPA 135
gi 291413117  57 DHPYCSPPGVSP---PPSR-PSSEVLLWRYPGSLIPEALRLLRLGDPPTPSHPATPA 109
gi 568815696  74 DHPYCSPPMTFSpalPPLRsPCSELLLWRYPGSLIPEALRLLRLGDTPSPPYPATPA 130
gi 395835807  76 DHPYCTPAVAFPpalPPLRsPCSELLLWRYPGSLIPEALRLLRLGDTPMPHYSAAPA 132
gi 731503718 159 HHPYCSPLRALPpvlPPLRsPCSELHLWCYSGNLIPEALRLLRLGDTP-PPTTLlpq 214
gi 928138008  76 DHPYCSPPMVFPpslPPLRsPCSELLLWRYPGNLIPEALRLLRLGDSPTPHYPATQT 132
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