Conserved Protein Domain Family
zf-C3HC4_4

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pfam15227: zf-C3HC4_4 
zinc finger of C3HC4-type, RING
This is a family of primate-specific Ret finger protein-like (RFPL) zinc-fingers of the C3HC4 type. Ret finger protein-like proteins are primate-specific target genes of Pax6, a key transcription factor for pancreas, eye and neocortex development. This domain is likely to be DNA-binding. This zinc-finger domain together with the RDM domain, pfam11002, forms a large zinc-finger structure of the RING/U-Box superfamily. RING-containing proteins are known to exert an E3 ubiquitin protein ligase activity with the zinc-finger structure being mandatory for binding to the E2 ubiquitin-conjugating enzyme.
Statistics
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PSSM-Id: 317611
View PSSM: pfam15227
Aligned: 10 rows
Threshold Bit Score: 57.0297
Threshold Setting Gi: 47214622
Created: 30-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 61252354   40 CPVCSDYLEKPMSLECGCTVCLKCINSLQKEPHGED---LLCCCC 81
gi 635067939  23 CPICTAYLEKPMSLECECVFCLSCTNSLQKEPQGEG---VLCPFC 64
gi 831225942  13 CPICSAYLEKPIYLECECIFCLNCIYSLQMEPHGEY---LFCYLC 54
gi 345316961  11 CPVCLDYFSYPTSIECGHTFCLSCIFRWSCSAAEVS---FTCPEC 52
gi 47214622   15 CPICLNLLEDPVTIPCGHSYCMGCISAYWQEQEA-----HSCPQC 54
gi 67972272   16 CPICLEYLKDPVTINCGHNFCRSCLNVSWKDLDDT----FPCPVC 56
gi 675772030  10 CPICLDYLQDPVTISCGHNFCFSCITISWKDLDDS----FPCPLC 50
gi 62087518   30 CPVCLDFLQEPVSVDCGHSFCLRCISEFCEKSDGAQggvYACPQC 74
gi 149722618  11 CRHCMSYLEKPMYLNCGYVCCLQCINSLQKEPDGEG---LLCPLC 52
gi 345316076  11 CPICSDYFHNPVSIACGHNFCQTCIDGVSLLP-------FRCPEC 48
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