Conserved Protein Domain Family
DUF4585

?
pfam15232: DUF4585 
Domain of unknown function (DUF4585)
The function of this protein domain family is yet to be characterized. It is putatively thought to lie in the C-terminal domain of the DNA nucleotide repair protein, Xeroderma pigmentosa complementation group A (XPA). The function of XPA is to bind to DNA and repair any mismatched base pairs. This domain family is often found in eukaryotes, and is approximately 70 amino acids in length. There is a conserved DPE sequence motif. In humans, this protein is encoded for in the chromosomal position, Chromosome 5 open reading frame 65. Mutations in the gene lead to myelodysplastic syndromes, where there is inefficient stem cell production in the bone marrow. This suggests that the protein may have a role in forming blood cells.
Statistics
?
PSSM-Id: 317615
View PSSM: pfam15232
Aligned: 20 rows
Threshold Bit Score: 75.8424
Threshold Setting Gi: 291387433
Created: 29-Jul-2016
Updated: 4-Aug-2016
Structure
?
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 992210122  3588 PFPVTQRKLLQDPNSGQYFMVDMPVpHVKTKMFFDPETGKYVQLNVHQrTQSALSQPESVEVL---NHSYVVYPGFLP 3662
gi 821455527   660 SGATPSGKVLVDPESGRYYYVEAPK-SPKLKLLFDPESGQYLEVLVP---------PSPAGPPlrfYPSLAVGHSLYP 727
gi 291387433   872 PAAAQPGKVLVDPESGRYYVVEAPR-QPRLRLLFDTESGQYVEVLLP---------PSSPAPPrhvYAPMAVGPGFYP 939
gi 545184780   878 PGAARPGKVLVDPESGRYYFVEAPR-QPRLRLLFDPESGQYVEVLLP---------PSPQGPTrrvYTPLALGPNLYP 945
gi 1025018646 1183 aagqtpRQLLLDPETGSYFYVDLPQ-LPQRKMLFDPETCQYVEVLLPQqTLPSAVLPTPCAIP---FASLHI-PPMYT 1255
gi 542175773  2490 SYGQTPRRVLLDPETGKYFYIEVPV-QPLRKMLFDPETGQYVEVLIPQqTMSHSGLYPPSAAP---YPPLPN-PSMYA 2562
gi 765163265  1135 aAPQTQRKMLLDPTTGHYYLVDTPL-QVTTKKLFDPDTGQYVEVPMPH---SPVAPVTPVHLS---LSPLALSPPAYT 1205
gi 987403772    21 QPQQTQRKMLLDVTTGQYYLVDTPV-QPMTRRLFDPETGQYVDVPMT----SQQQAVAPMSLP---VPPLALSPGAYG 90
gi 597783190  1177 HFQATQRKMLLDPTTGNYYLVDTPV-QPATRRLFDPETGQYVDLPMP-----PQPPMTPVHMP---ISPLALSPGTYG 1245
gi 47218466   1027 gdAQTQRKMLLDPTTGHYYLVDTPF-QPATRRLFDPETGQYVDVPVPRpAAAHVAPISPVSLS---VSPLTLGPAAYA 1100
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap