Conserved Protein Domain Family
CCDC66

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pfam15236: CCDC66 
Coiled-coil domain-containing protein 66
This protein family, named Coiled-coil domain-containing protein 66 (CCDC) refers to a protein domain found in eukaryotes, and is approximately 160 amino acids in length. CCDC66 protein is detected mainly in the inner segments of photoreceptors in many vertebrates including mice and humans. It has been found in dogs, that a mutation in the CCDC66 gene causes generalized progressive retinal atrophy (gPRA). This shows that the protein encoded for by this gene is vital for healthy vision and guards against photoreceptor cell degeneration. The structure of CCDC66 proteins includes a heptad repeat pattern which contains at least one coiled-coil domain. There are at least two or more alpha-helices which form a cable-like structure.
Statistics
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PSSM-Id: 317619
View PSSM: pfam15236
Aligned: 15 rows
Threshold Bit Score: 105.218
Threshold Setting Gi: 321461118
Created: 29-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121992493   412 HDLKDGSEDDVQSMQSSS-----------TYLRGQNAPLDAQTLAERMDKRRkASEYHNAIKKQLHEREMIRKWELERHR 480
gi 358335333   642 HFSASIPIPDLMCTDFGAvtttr-pvsqfNRTRGFTQTLYSSPADEAARLRR-AEEIQRANLEQIEEHRRIRELERANRL 719
gi 1023020899  505 plSGGQLGSAEENLGKSTqdvattnvektSFLRSMTALLDPAQIEERDRRRQkQIEHQKAITAQVEEKRRKKQLEEQQRK 584
gi 269785217   412 TTGSQVEPSEEEHIAKPVrdmamansqktNFLRSMTALLDPAQIEERDRRRQkQLEHQKAITAQVEEKRRKKQLEEQQRK 491
gi 968077258   376 KD----SEDDIQSLQSSS-----------TYLRGQNAPLDAHTLQERIDKRRrAAEYHNAIKKQLHERELIRKWELERHR 440
gi 195020897   460 HDLKD-SEDDVQSMQSSS-----------TYLRGQNAPLDAHTLAERMDKRRkASEYHNAIKKQLHERELIRKWELERQR 527
gi 968116672   446 HDLKD-SEDDVQSVQSSS-----------TYLRGQNAPLDAHTLAERMDKRRkAAEYHNAIKKQLHERELIRKWELERHR 513
gi 195591924   445 HDLKD-SEDDVQSMQSSS-----------TYLRGQNAPLDAHTLAERMDKRRkAAEYHNAIKKQLHERELIRKWEQERHR 512
gi 332028924   236 sqvlvinhDSASSPDSSTtgstgsdinkvSYLRGQNIPMDAEILQEREMKRQkALELQNAIKQQLEEKDRQRKEEKERRL 315
gi 321461118   269 PPRWVARPTNATFVQTEPlms-----ggpSFLRGQNVVVDVAELAERERKRAkANELQRVLLQQLAEKENQKLLEKKRQQ 343
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121992493   481 QEEQIEEERLRRQKQMDQERAEYERRQQLEREEAQQKKQQAMLDAIAKAEVAAQMEKQQKRKKPQPqpqpqpqtvpkdgp 560
gi 358335333   720 LEDKLEEERLERERAQLRAIAEAENKEKQLREMEENTRTQILLDNLKQAREEAANYRTQVRFRRGG-------------- 785
gi 1023020899  585 QEEDEEERRLAREREEMQRRFEEDLLEQKRKEEMMALKTSELYQSMQRAQELAQRLRQEQRIRELE-------------- 650
gi 269785217   492 KEEQEEERRLAREREEMQKQYEEDILKQKQKEEIMTLKTNELFQTMQRAQELAQRLKQEQRIRELA-------------- 557
gi 968077258   441 QEEQMEEDRLRRQKQMEIERLEYERRQALEREEAQKKKQQVMLDAIAKAEVAAQKEKQKKRKNREE-------------- 506
gi 195020897   528 QEEQLEDQRIRRENLMEQERLDYERRQLLEREEAARKKQQALLDAIAKAELAAKIEKQKKRQKHVPpieqspsqer---- 603
gi 968116672   514 QEEQLEEERMRRQKQLEQERLEFERRQLQEREEAQKKKQQAMLDAIAQAEMAAKMEKQKKRKNRMP-------------- 579
gi 195591924   513 QEEQIEEERIRRQKQLEQERLEFERRTLLEREEAQQKKQQVMLDAIQKAEVAAKIEKQKRRMVHQPskvsqeteedd--- 589
gi 332028924   316 REEMLEEERIRRERERDKARFEEEQRIIREKEEAKLRKTQAMREVLEAAERLAKEDGKNRRKRE---------------- 379
gi 321461118   344 EEEERQELELQRHLEAERRQIEEERRRVQEKKEAEERRLEAVKEAIAGAQQNALAEKL-ARRRNL--------------- 407
                          170
                   ....*....|....*...
gi 121992493   561 qegellrvqsveEEEEEA 578
gi 358335333   786 ------------VDQQNP 791
gi 1023020899  651 ------------QKGHDI 656
gi 269785217   558 ------------QKGHDT 563
gi 968077258   507 ------------VKVKTT 512
gi 195020897   604 --pellrvlsveEEEEEQ 619
gi 968116672   580 ------------SKEHRQ 585
gi 195591924   590 --eaelmrvqsvEEEEDA 605
gi 332028924   380 ------------EHTDED 385
gi 321461118   408 ------------QNRTAV 413
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