Conserved Protein Domain Family
DUF4586

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pfam15239: DUF4586 
Domain of unknown function (DUF4586)
This protein family, refers to a domain of unknown function. The precise role of this protein domain remains to be elucidated. This family of proteins is found in eukaryotes and are typically between 256 and 320 amino acids in length. There is a single completely conserved residue, phenylalanine (F), that may be functionally important. In humans, the protein is found in the position, chromosome 4 open reading frame 47.
Statistics
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PSSM-Id: 317622
View PSSM: pfam15239
Aligned: 38 rows
Threshold Bit Score: 179.09
Threshold Setting Gi: 255084275
Created: 29-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74830231    5 SAFGGLFSDPPLVSTDidpkktDPYdkmdtiPSRYLGKGMSIG------------RCPSGNGPEVFFDK-KFLTLasAEq 71
gi 124456476  23 RERHGLFNQPPPLLIG------DQY------NDALKSQGKEKGvl--------vnKKLQKKHEPTLFLEpGYTTL--ND- 79
gi 124447764  25 VQRFGLFSSPVPLGLG------Dns-----yDNKPRPARNEQGkpitsppnmkvtATQSGKIKSSYFSQlGFTTI--GD- 90
gi 124461200  28 KQRFGLFSSPVPLGLG------Dds-----mEMRKRPQRGENGkpitepsnmkvcATRTGRIRSSYFGPlSFTTV--GD- 93
gi 122047332   5 svYGGLFSDPPLISTDgdpkrtDPYdkmdtiPSRYLGKGMSIG------------RSGTGQNAEVYFDK-KYLTLasPEq 71
gi 471236785  33 KQRFALFSQPPSLATG------Ddk-----qYQKIYHQRDENGkpitearniqstALKRGKAKDAYFSVlGFTTI--GD- 98
gi 303287422   2 SNKYGTFSDAGYLAVG------DPYl----dGKDPLAQSSRYRglnm-----kasTRKTGKDNRACFDK--LKPLyaNE- 63
gi 255084275  26 pDKYGSFSNPGSLNVG------VPYtgkdplAQGNSRLRGVNmk---------apSAKMGKGNDASFD--RFKPLyqKE- 87
gi 389594185  77 svYGGLFQDPPYLSSDpdpkktDPYdkkdaiPSRYL------Gknmt-----iggRVPPGQHPDAYFDK-RFLTLasSE- 143
gi 146093353  72 SVYGGLFQDPPYLSSDpdpkktDPYdkkdaiPSRYLGKNMTIGg-----------RVPPGQHPDAYFDK-RFLTLasSEq 139
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74830231   72 nnnksvgPF------EDATTRMHRERREAKKHNISn--KDFLPPSFPKSINGP---------------Ggys-------- 120
gi 124456476  80 -------PY------KDQFKAKQIYDKERELAIKNp--NCFKPNDHVKSIKHS---------------E----------- 118
gi 124447764  91 -------KY------IDPERKIRIQELEEKKKYANddkKNFVPPSGYKELVGG---------------V----------- 131
gi 124461200  94 -------PY------IDPEKVLTIYEKEQKKLCNKe--AAFKPPSGYKELMGS---------------A----------- 132
gi 122047332  72 ngnkdlgAF------EDADTRMRREAMESKKKNISe--KVFLLPSYPKWSDGP---------------Gsys-------- 120
gi 471236785  99 -------KY------IDPDSINRQYELEKKKKIKQd--QVFKPPSGYKTIINS---------------Afkhen------ 142
gi 303287422  64 -------KY------ALTNEERAARRETEKAGKVTd--KPFKPTSLTKHACGL---------------Ggyggciggkhe 113
gi 255084275  88 -------PF------QVSAAEKREARAKAEDGRIQ---GPLVPAGMPKKSSGLggyggtlgepfenedGepyfgwgt--- 148
gi 389594185 144 -------QNggkpvdYDESKQRTAASRTNTKNAISd--KEFCYSSYPEKSTGP---------------Gsyygcfq---- 195
gi 146093353 140 ngg--------kpvdYDESKRLTAASKTNTKNAISd--KEFCYSSYPEKSTGP---------------Gsyy-------- 186
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74830231  121 --------gcFQErpyefimpgeeggpkskkskrkkkasS------------SEEDSKGKELLPNIKTNPSKKGT-YGYV 179
gi 124456476 119 ----------FEHmkefn----------------dkvfnT------------RTPKGDVRTQARNFLTNPAKKGLgRTTT 160
gi 124447764 132 ----------YNHeadyei--------------pkgpnnH------------KGGDGRVKIGPKNVTTNPGSS------- 168
gi 124461200 133 ----------YSHmkeydy---------------kkvesR------------KQTDGRVYSAPRNVTTNPRCK------- 168
gi 122047332 121 --------gcFQDrpypfilpgen----dkksrrrkkaaV------------TEVTDKNKSSLPNIKTNRTKKGT-YGVP 175
gi 471236785 143 -----edvynKKN--------------------------Y------------RDADGKVLTQSKNITTNPSSK------- 172
gi 303287422 114 svpggdvdpnDEK--------------------------L------------MKGDPRLDEKPRQITTCPGKKGS-YGTR 154
gi 255084275 149 -----adgeppkG--------------------------L------------MKGDPSTQPKPRNIVTGPGKKGg-YGMR 184
gi 389594185 196 ----nrpyeyMTE--------------------------PwddgkskkkkraPKPKEEEPTHLPNIKTNPAKKGT-YGYP 244
gi 146093353 187 --------gcFQNrpyeymtepwd-----dgkskkkrttK------------T-KEEE-PTHLPNIKTNPTKKGT-YGYP 238
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74830231  180 GILLDNp---------KYN--DDWrkehEKLE-----AAEAKK-RKKLAPPKPLG-P-L-FRTPGVIH--DYLDE----- 232
gi 124456476 161 NNLFGQ----------IEYipDPY----DRQE-----ELDRQD-RIKHRSKFLPGtT-R-FITTSHGN--RPFTAdgill 216
gi 124447764 169 --SLGHf---------PKHekDEY----NRYR-----QFERE--KIFNEQKMLKDkQ-P-FKSTIYTT--DNFSTdkqif 222
gi 124461200 169 --VLDKs---------IPYltDDY----NRYS-----DFERKArMESKSKEKe---Q-P-FRSTVNGG--YTFEKdknif 221
gi 122047332 176 GTLLDNp---------KYN--DNWrqemEKLD-----ALRAKR-EKNVPQPKPMG-S-P-FKTPGVTH--DFLDE----- 228
gi 471236785 173 --LQSKh---------YPHlpDQY----ERQR-----QLRIQE-MK-KHQELLGE-KaA-FRSTVFGR--RNFFNdkktf 226
gi 303287422 155 GTTLGGpkghg-vageYSYkgDEY----DAER-----KANA-A-REREGKKKMQG-S-A-WAPARAPKkgGYGTRgttig 219
gi 255084275 185 GYTLGEkksaggsageYKYvaTDY----DAER-----KADA-A-RAAHGKKLMAG-K-PdWKPTAPGK--R-GGPgvtgk 248
gi 389594185 245 GLLLSNp---------SYN--DDW----KKDYaaaeaNRARRE-RKQGPAPKALG-P-P-FHIPGVSH--SYIDE----- 298
gi 146093353 239 GLLLSNp---------SYD--DDWkkdyAAAE-----ANRARReRKQGPAPKALG-P-P-FHIPGVSH--SYIDE----- 292
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74830231  233 ---------LPATGVSGVY--Hfepadek----------------pskrkrkNKQEAAGPtfvqeramtfvwtrSGNEGN 285
gi 124456476 217 ----dgagyLSAKKRPLYKgaP------------------------------FRPANQNK--------------NGFQGT 248
gi 124447764 223 ----getnlPKPTQVKEFKpnImkh------------------------eapFKPSNPTK--------------SGETGC 260
gi 124461200 222 ----gvtkmPPQSQRKSPDlkSakh------------------------esaFRPANGLK--------------KGFDGL 259
gi 122047332 229 ---------LHATGVSAVY--Hyepveek----------------spkrkgrVKSPAAVAvftqerpmsfkrtkSGQEGC 281
gi 471236785 227 geeglnlkkRPQTNIK-FN--Iinh------------------------dapFKPSNPNKrvfiyiikkificyKGWNGT 279
gi 303287422 220 -----gpkgAGVVGEYSYK--Eegpelpep--------------kgspiekqWRPSHPPKr--------------GYNAT 264
gi 255084275 249 tl-agpknlGGVCGEYRYK--Pegpdpkfv--------------peppadypWAPPKPNK------------------GP 293
gi 389594185 299 ---------MPNTGVSAVY--AayeapadsaaekrkakreaaaaptlvheraFYGSAn---------------rSGEPGC 352
gi 146093353 293 ---------MPNTGVSAVYaaYeapadsa-----------------aakrkaKREAAAAPtlvherafygsanrSGEPGC 346
                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 74830231  286 IDPFpNTWIDVAALeeeekkknrrrrrakA-K-DTYVPGPPKGA--T--GVWKP--N-------TFECTSvvqSCLR 347
gi 124456476 249 FEVL-QYMEEGVPDp-------------kT-K-QNTFQKLSATQtyE--NPWRPnsNgtf--arPCPSVS---QQLR 302
gi 124447764 261 LSKYpQYKGDP------------------L-K-PTQRIDFV-KG--K--DPFKPnhLmem--vrPTPSIScfpHNLK 310
gi 124461200 260 FGHF-QYKSDP------------------M-R-EIKRQFSSKKE--R--ESFKPadLgnk--trPNPTIScfkMNIR 309
gi 122047332 282 IADFpNTWIDPDALerernkg--kkknrkP-K-PEYVPSPPKGA--S--GIWKP--N-------SFPEASvvqSCLR 341
gi 471236785 280 LSKFpEYKPNGE-------------------K-QAKRQFMI-KE--K--DPFKP--KycgeltrPTPTISchpLNIR 329
gi 303287422 265 LQRFpKHMADPAEL---------------KiA-AAREKMEADAEliE--KPFVP--Pftg--ckSQATKSvvkMNLg 319
gi 255084275 294 MNPFpEHMADPEEL---------------Q-KwKERRREKEGRA--KitKAWRP--Ggg---gkSGATKSvlrMNTR 347
gi 389594185 353 LNPFpNLWVHPDETqpskia---lrkqaqK-E-KEEAARQPKRT--E---VWRP--Nsf-------gkTSvvsSCLR 410
gi 146093353 347 LNPFpNVWVHPDETqpskfa---lrkqaqK-E-KEEAARQPKRT-----EVWRP--N-------SFGKTSvvsSCLR 404
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