Conserved Protein Domain Family
NCKAP5

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pfam15246: NCKAP5 
Nck-associated protein 5, Peripheral clock protein
NCKAP5 is short for Nck-associated protein 5, which is also known as the Peripheral clock protein. NCKAP5 is a protein family, which interacts with the SH3-containing region of the adaptor protein Nck. Nck is a protein that interacts with receptor tyrosine kinases and guanine nucleotide exchange factor Sos. The role of Nck can be thought of as similar to Grb2. The role of NCKAP5 is to assist Nck with its adaptor protein role.
Statistics
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PSSM-Id: 317628
View PSSM: pfam15246
Aligned: 21 rows
Threshold Bit Score: 322.834
Threshold Setting Gi: 119578501
Created: 29-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123779270  1299 LSPSIEEKVMLCIQENVEKGQVQTK-SASVEVKPRAGPSFTSWFGFRKSRLPALSSRRMEASKSKVEKKDt--------- 1368
13_pfamImport    1 TVTTIEEKVMMGIEENVQKCQEQEK-VAATEAKQKTGPSLANWFGLRKSKLPALSSKKADSPKGKEEKKElkigsvlggk 79
14_pfamImport    1 TVTTIEEKVMMGIEENVQKCQEQEK-VAATEAKQKTGPSLANWFGLRKSKLPALSSKKADSPKGKEEKKElkigsvlggk 79
20_pfamImport    1 PQSAIEQKVMKGIEENMLKLQVQDR-GQVVEVKQKTSNGIASWFGLKKSKLPALS-RKADVAKLKEDKKEwklnmpsagk 78
18_pfamImport    1 HQSAIEQKVMRGIEENMLKLQEQDR-GQPPETKQKTSNGIASWFGLKKSKLPALN-RKPEMSKLKLNVSSsssss-saak 77
1_pfamImport     1 PQSSIEQKVMKGIEENVLKLQEQDK-GQVVEVKQKASNGIANWFGLRKSKLPALS-RKPETSKVKDDKREwkln---isk 75
17_pfamImport    1 PQSSIEQKVMKGIEENMLKLQEQDK-GQVPEVKQKASNGIANWFGLRKSKLPALS-RKPEPSKGKDEKREwklnissvgk 78
10_pfamImport    1 LQSAIEQKVMKGIEENVLKLQEQDRgGQGAEVKQKTSNGIASWFGLKKSKLPALS-RKADAAKAKDEKKEwkinipsvgr 79
15_pfamImport    1 PQSAIEQKVMKGIEENVLKLQEQDRgGQGGEVKQKASNGIASWFGLKKSKLPALS-RKTDGTKAKEEKKEwkinipsvgr 79
gi 556946318  1136 NQSAIEEKVMKGIEANMLKLQGQDR-VHVVEVKQKTSSGIAGWFGRKKSKLPALS-RKPETSKGKEDKREwkvtsspvtk 1213
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123779270  1369 kLKSER--KKE-----------KKKAEVQSKIENELSRGTK-KAdgqsPDDGLQSSESLKVSQDIYNQMKLEPRNRPSPA 1434
13_pfamImport   80 qMKSDK--KKD-----------KKKNDNQQKESQEVQGLSE-M-----------NNKLSSIMDHCNNQMGQIASQIQCTT 134
14_pfamImport   80 qMKSDK--KKD-----------KKKNDNQQKESQEVQGLSE-M-----------NNKLSSIMDHCNNQMGQIASQIQCTT 134
20_pfamImport   79 dPKVATk-KKLeveslnisklmEKAEDLRKALEEERAYVN---GvaldRASRGHS---------CEVVMDQNQSQLSVVY 145
18_pfamImport   78 dASGAKggPRKvveslnisklmEKAEDLRKALDEERTYVNR-VGialdRPGRGHS---------CEVVMDPSQGQLSLMY 147
1_pfamImport    76 dSKGAA--KKPeseslnismliEKAEGLHKALEEERAYVNG-VAl--dRQGKGHS---------CEVVMDQAQGQLSVMY 141
17_pfamImport   79 dSKAAA--KKPeseslnismlmEKAEGLHKALEEERAYVN---GvaldRQGKGHS---------CEVVMDQAQGQLSVMY 144
10_pfamImport   80 dSVKVTsrCKEgveglnistlmEKAEGLRRALEEERAYVE--------RSGRGHS---------CEVVMDQAQGQLAVMY 142
15_pfamImport   80 dSVKMAsrCKEgveglnistlmEKAEGLRRALEEERAYVE--------RSGRGHS---------CEVVMDQAQGQLAVMY 142
gi 556946318  1214 eVKQAA--KKLeveslnismlmEKAEDLRRALEEEKAYINGiSL----EKSRLHP---------CDVLVEQTQNELKVMY 1278
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123779270  1435 VCPTKDAFMTELLNRVDKRAS---VQRESGSKGVSCRSVLEGTSQGS-----------CFASGSVSTQGSQKKNIKTKVD 1500
13_pfamImport  135 AFIGKDQFVKELLGRRVDKRStrhTDMKNRSNLISSQDRCEGQLRGH------------IAAWDLHAQETQRNENKTSNT 202
14_pfamImport  135 AFIGKDQFVKELLGS-EHKQFvdqTHSQQHSGLMTAVKGSSVATSPP-------------------GISTPKKHSETKGD 194
20_pfamImport  146 REVTSDTFMQQLLNRVDERDS--------SGNGLAHRRLSFDSKKSR-----------PIFSSQRNGIISHAKSRQEVAK 206
18_pfamImport  148 RGVTADNFMQQLLNRVDERGA--------PGFGIVHRRLSFDSKRSR-----------PVFGHQQNNI-SHTRSREEMDK 207
1_pfamImport   142 RGVPSDNFMQQLLNRVDGKDT--------SGISMAHRRLSFDCK-SR-----------PVFSHQSAAIASQTRSSDDMEK 201
17_pfamImport  145 RGMPSDTFMQQLLNRVDGKEA--------GSVSVAHRRLSFDCK-SR-----------PVFSHHSTTV-SQTRSSEDMER 203
10_pfamImport  143 RGGRSDNFMQQLLNRLEESEI-------------------------KhpppetpftllPAFFPNACICCTQGGREGEVSE 197
15_pfamImport  143 RGARSDNFMQQLLNSEENRKL---------STELYHESFPLFSSSDSsssptpnitcmPLFM---------------CAN 198
gi 556946318  1279 QEMTTDNFMQQLLNRVDDKGAvyeSRTGEKSHPRSFQKASHESKSATa----------PLSAQRSTCPRQTIKDLQDTEK 1348
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123779270  1501 MEKPRESLGAEVNEDVQ---ED---EEDRVADTTLQSHM---IESNCQMRTLDSGIGTFPLPDSGNRSVGRYICQQDSPE 1571
13_pfamImport  203 FHK-ARSLSSPLESHIA---EN---VEGHIPDAACQDHM---LGFGCQMRTLDSGIGTFPLPDSVTRASGRHIPKSESSP 272
14_pfamImport  195 MEICSDTATLIMTEKINlkaEN---VEGHIPDAACQDHM---LGFGCQMRTLDSGIGTFPLPDSVTRASGRHIPKSESSP 268
20_pfamImport  207 -----------ATDLVC---KGditSDESLTESVNSQHF---AGSGSSTRTLDSGIGTFPLPDYAGCVAGKLVPKVKPRG 269
18_pfamImport  208 -----------GSDMVS---RDeitSDESLAESISSQHF---TGSGSSMRTLDSGIGTFPLPDYASSAAGKGVPK--PQG 268
1_pfamImport   202 -----------VSALLS---KDv-tSDDNLAETIHHEHF---AGSGISTHTLDSGIGTFPLPDYSANAGCKSIPKGKAHG 263
17_pfamImport  204 -----------GSALMS---KVdgvSDENLADSIHHERFagkAGGGVYTLKLDSGIGTFPLPDYSANAGCKSIPKGKAQG 269
10_pfamImport  198 LQPPPCCLTQ-GSQRIG---Kl--tSDENLADSVHSQHF---AGSGASTYTLDSGIGTFPLPDCSSSGTGRGLSKARGGA 268
15_pfamImport  199 TWPIKPILTPNGSERIG---Ki--tSDENLADSVHSQHF---AGSGASTYTLDSGIGTFPLPDCSSGAAARGLSKTKGGA 270
gi 556946318  1349 -----------AADLVN---KDditSDESLADSVTSQPF---AGCGSLTRTLDSGIGTFPPPDYPSSPTGISIPKLKSKF 1411
                          330       340       350
                   ....*....|....*....|....*....|..
gi 123779270  1572 DTDAL-LPLQPAA-SMASSARAQTLDREVPSS 1601
13_pfamImport  273 E---------------GVTGGSSELDREPPSS 289
14_pfamImport  269 E---------------GVTGGSSELDREPPSS 285
20_pfamImport  270 DQEFS-APLGKAGpVTKVPRKARTLERELSSL 300
18_pfamImport  269 DQGFF-CSQGKQGaLLKAPRKARTLERERSS- 298
1_pfamImport   264 ESDPS-HLQPKHAsGMKMSHKAWSLERELSSL 294
17_pfamImport  270 ENDPS-LPPGRHGsGMKIPHKAWTLERELSSL 300
10_pfamImport  269 EHHST-DSPG------RAGRRARTLDREPTPQ 293
15_pfamImport  271 EHHSAgGSPG------RAERRARTLDRELTSQ 296
gi 556946318  1412 EQPAC-LPPGKSLsVTRVPCKARTLERDMPSg 1442
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