Conserved Protein Domain Family
DUF4588

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pfam15251: DUF4588 
Domain of unknown function (DUF4588)
This family of proteins is found in eukaryotes. Proteins in this family are typically between 200 and 274 amino acids in length. There is a conserved LYK sequence motif. There is a single completely conserved residue A that may be functionally important.
Statistics
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PSSM-Id: 317633
View PSSM: pfam15251
Aligned: 11 rows
Threshold Bit Score: 174.642
Threshold Setting Gi: 149239120
Created: 29-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123893322   25 ERQCL------AEAEQED--QPEEEAEq---------sQQKLWHLFQNSATAVAQLYK-Drv-cQQ---------QGLSL 76
gi 762147213   21 EEECIee--lhSETNMEEalEKQQELA-----------EQKLWLQFQNSATAIAQLYK-D----RH---------QGLSL 73
gi 260801765   19 EQQCVee--veGEGNMEErlAGEREDVa-----------QKLWLSFQNSATAVAQLYKgNtc-nRG---------QGSHV 75
gi 72004461    23 EAQCLeeldreLEPNLDErlPQEKQFAs-----------EKLWYSFQNCASAVTTLYKeRln-qSN---------IHIPL 81
gi 1022767631  21 ERQCEie--leNEPDLDQavQSERDLSt-----------QKLWYLFQNSATSVAQLFK-D----RN---------QPQVL 73
gi 149239120   28 lsgtgaaaasvtssqstsstsstsstAd----------YTDLTTHFKDAAKAIASLYN-TalgvQNltntndetpQKLTL 96
gi 260944350   17 EQVSLvd------------------------------lNRDLTNEFKNTAKAVASLYNaTsq-aEC---------EHRSA 56
gi 348557929   21 ERQCLa----eAEAEQGEtlPPEQQAEataeaegirgeLQRVWHLFQLAANAVAQLYQ-Dse-cQQ---------PEQSV 85
gi 532078876   21 ERQCL------DEAEQDEqlPPELQEEaaaeaaglkseQQRLWHLFQISATAVAQLYK-Dsg-cQQ---------PGLSM 83
gi 558098802   38 pelqD------DKDDEDD--KGDEEAlgp------kseQQKLWHLFQISANSVAQLYK-Gse-cPQ---------SELSM 92
gi 410917750   25 ERQCL------AEAEQSD--PKEEETEq---------sQQKLWHLFQNSATAVAQLYK-Drv-cQQ---------QGISL 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123893322   77 WVPFQNAATAVTNLYKESVDA-HQRSFDLGIQIGYQRRNKDVL----------AWVKKRR-RTIRREDLISFLCGKVPP- 143
gi 762147213   74 WVPFQNAASNVTSLYKDGVDS-LHNCVDFGIQKGKQYRNRDIV----------AWVKKKR-RNIRREDLLAFLCGKNPPa 141
gi 260801765   76 WQVFQNAAQAVTLLYKDSIDA-NKRSEDFGIQCGYQRRTRDVV----------AWAKKRR-RHIRREELLAFLCGKTVPs 143
gi 72004461    82 WLVFQNAAGSVTQLYKESTDA-QKGSLDLGISIGHQRRTRDIV----------AWVKKRR-RHIRREDLLAFLCGKAPPg 149
gi 1022767631  74 WLPFQTAAGTITSLYKESTEA-LRRSSELGIQAGYQRRAREML----------AWAKKRRgRNIRREELIAFLTGKSVPg 142
gi 149239120   97 KTDFAQAARSVAVLYKYA-----QMSHPASFDQGYLNCIDDLLqiitndedveNWALTRR-AEITKLQKTSNKDNERERk 170
gi 260944350   57 KTEFSNAAKAVASLYRTGS-----NSNVLSMHKGYLDCLDDMLrvitndedieSWVLTRR-AELTNSYNTNQNHGAGSPg 130
gi 348557929   86 WDPFQRAAMAVTDLYKESGddarrRCLDLGVQVGCRRRVGDVL----------EWAKKGR-STIRREDLISFLCGKAPPe 154
gi 532078876   84 WDPFQNAAMAVTSLYKESGda-hqRSFDLGVQVGYQRRIKDVL----------EWVKKGR-STIRREDLISFLCGKVPPa 151
gi 558098802   93 WDHFQSAAMALTSLYKESRda-qqRSFNLGVQVGYQRRIKDVL----------DWAKKGQ-STILREDLISFLCGKVPPd 160
gi 410917750   77 WVPFQNAATAVTNLYKESTea-rqRSYDLGIHLGNQRRNKDMI----------AWVKKRR-RTIRREDLISFLCGKVPP- 143
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123893322  144 ------PRNSRAPPRL-TVVSPNRATPT-----ET----GSSV------------ETD----LQPFREAIALHGLSGAMA 191
gi 762147213  142 rn-rhaSSMVRHSQSS-RLSVERTHSPRlqgpeSL----SSGN------------EPD----LQAFREAIALQGLNGAMS 199
gi 260801765  144 ------rTGSRSPPRStRDSPRLGSQEY-----AP----SHQS------------EID----LQPFKDAIALQGLNGAMA 192
gi 72004461   150 ri--rpSHGVPRSPSD-RSSPRTHSPPR-----EAqrtgLGEP------------VDD----LQPFRDALALHGLNGAMA 205
gi 1022767631 143 sgasqpRHQMRMGPRP-RVSLSDGMSAS-----HH----GPSAlqhplegsagdfEPA----LQAFRE----------AL 198
gi 149239120  171 ek-gerERDR--------DRDRERERER-----EK----DIES------------DSV----LNFSQKSVVKNSLDSLQS 216
gi 260944350  131 rasvshNTHERLTDEA-FPVRTN---------------------------------KDsshrLRDFDEASSENSKKNTTE 176
gi 348557929  155 a---ppPRAPRTPPKP-PAGAAGqaavte---------------------snpsvdVD----LQLFHEAAALHGLDGAAA 205
gi 532078876  152 p---ppPRTSRMPPKP-PSGAASqagate---------------------ssssvdVD----LQPFHEAIALHGLNGAMA 202
gi 558098802  161 pp-pvpPHLPPVPPQL-PPVPPHlpppyspkm---------------atessssldFI----LQPFQEAINLHELSGAMA 219
gi 410917750  144 ------PRAPRAPPRV-ASRSapqet-------------------------gssveTD----LQPFREAIALQGLSGAMA 187
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123893322  192 S---------------------I--S--VRSSTPGSPTHv----SGSSNTGRRRNgl--------hD--VDLNTF----- 227
gi 762147213  200 N---------------------ItmG--FSMSQGATASP-----QIGALPKSNGN-----------M--EELNRF----- 233
gi 260801765  193 S---------------------F--G----LRTPTSPSH-----NMHSTPSRRRN-----------L--GELHAF----- 222
gi 72004461   206 N---------------------I--G--VSQSPSSHHSSs----RRRHLSN---------------------HDL----- 230
gi 1022767631 199 S---------------------L--P--LPSSASSNNTNn----ASSAKSTGRRGspv------hnH--SELSAF----- 236
gi 149239120  217 Ktafddgkl------psdfafqF--A--LDLRPPTAFRPsipplSVLHNPSQRNLa------------iSKKNRFhqqil 274
gi 260944350  177 KkfsnngtandlsssqlhtdyeF--SlpQELMSHVVFRPsfpplSVSFKRSKKWCdikdrkmpislQdaSGSSDC----- 249
gi 348557929  206 S---------------------V--G--VPTGAPGSPPQg----SGVACGGRTQSsf--------lE--DDLNRF----- 241
gi 532078876  203 S---------------------I--S--VRSGAPGSPPQd----SGVASSGRRKSsf--------lE--DDLNPF----- 238
gi 558098802  220 S---------------------I--S--VQSGPPSSPSQagafsSNVATGDLQNSst--------lK--EDLSSC----- 259
gi 410917750  188 S---------------------I--S--VRSGPPGSPTHp------AQPHGRRRNgl--------hD--VDLNTF----- 221
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|..
gi 123893322  228 ----ISEEMALHl--dNGGTRKRTSAQcGDVITDSPTHKRNR 263
gi 762147213  234 ----ILDEFSRN----YDTARKRTSSP-DNTLIDSPSRKKSR 266
gi 260801765  223 ----ISEEFANHmdsnSPNGRKRSSGN--DLLGDSPVHKRSR 258
gi 72004461   231 ----FPEDLVSH-----PDSRKRSSTNiAPTVEGSPSHKRSR 263
gi 1022767631 237 ----ISHESARH-------KRPAPASPtHDVIMDSPTHKRSR 267
gi 149239120  275 kkvhSSEDSSES----ESDDLKRVKIFkDNT---SPSRKKKR 309
gi 260944350  250 ----DSDDgitd----adikKKRLA----HSlheVPKRQKRA 279
gi 348557929  242 ----GSEElglhl--dsggiRKRPSTQlGDCftdSPSHKRNR 277
gi 532078876  239 ----GSEElalcl--dsggiRKRTSAQfGDGitdSPSHKRNR 274
gi 558098802  260 ----NSEDlalhl--asggnLKRTSGQcDDVitnFPTHKRNR 295
gi 410917750  222 ----IAEEmarhm--dstatRKRGPTPcSDVitdSPTHKRNR 257
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