Conserved Protein Domain Family
DUF4589

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pfam15252: DUF4589 
Domain of unknown function (DUF4589)
This protein family is a domain of unknown function. The precise function of the protein domain remains to be elucidated. This family of proteins is found in eukaryotes and are typically between 215 and 293 amino acids in length. The protein contains two conserved sequence motifs: SSS and KST.
Statistics
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PSSM-Id: 317634
View PSSM: pfam15252
Aligned: 23 rows
Threshold Bit Score: 151.53
Threshold Setting Gi: 0
Created: 29-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123888017   48 EVVGQIDKLTSDLELDLD--ADDWTVATASSTSSSERGLCe---AF-RLDFLGQDSLSDSWDFCSFLESSsrrsarddtK 121
17_pfamImport   1 EVVSQIDKLTSDFDFELE--PDDWTTATVSSTSSSDKAGVggpfDLgHLDFMTADILSDSWEFCSFLDAS---------T 69
5_pfamImport    1 EVVSQIDKLTSDFDFELE--PDDWTTATVSSTSSSDKAGVggpfDLgHLDFMTADILSDSWEFCSFLDVS---------T 69
10_pfamImport   1 EVVTQIDKLTSDFDFELE--PDDWTTATVSSTSSSDKAGVggpfDLgHLDFMTADILSDSWEFCSFLDVS---------T 69
9_pfamImport    1 EVVSQIDKLTSDFDFELE--PDDWTTATVSSTSSSEKGGGsgpfDLtHLDFMTSDILSDSWEFCSFLDIS---------T 69
4_pfamImport    1 QVVSQIDKLTSDFDFELE--PDDWTTATVSSTSSSDKGGgg-lfDLgHLDFMTSDILSDSWEFCSFLDVS---------T 68
15_pfamImport   1 QVVSQIDKLTSDFEFELE--PDDWTTATVSSTSSSDKGAgm--fDLgNLDFMTSDILSDSWEFCSFLEAS---------T 67
18_pfamImport   1 QVVSQIDRLTSDFALDLE--PDAWTPATASSTSSSDRGGAs--lELgPLDFASSDVLSDSWEFCSFLDAS---------T 67
6_pfamImport    1 EVGEDVGSSPQQTSYSFAesKPKHTKSRKAPRSFSSKGTAqnpsDKsLLSFQMS-IVSGMLFYQSFLPLS---------L 70
2_pfamImport    1 EVVSQIDRLTSDFEFELE--PDDWTTATASSTSSSEKGGVs--fELgPLDFAAADILSDSWEFCSFLDTS---------T 67
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123888017  122 PPPTTA--------------SVYSQMN--GGLPvPNGPL--IITPDSSSEeassS---THSQSQKTSRTAGTRERVRFSD 180
17_pfamImport  70 PSDSVDgpelt----rpgagPDYRLMN--GGTPiPNGPR--VETPDSSSEeafgA---GPVKGQLPQRTPGTRERVRFSD 138
5_pfamImport   70 PSDSVDgpesa----rpgagPDYRLMN--GGLPiPNGPR--VETPDSSSEeafsA---GPAKGQLPQRTPGTRERVRFSD 138
10_pfamImport  70 PSDSVDgpess----rpgvgPDYRLMN--GGTPiPNGPR--VETPDSSSEeafsA---GPTKG---QRTPGTRERVRFSD 135
9_pfamImport   70 PSDSGEgpepa----rqpptPDYRLMN--GGVLiPNGPR--VETPDSSSEeafsScppDPPKGQQAHRTPGTRERVRFSD 141
4_pfamImport   69 PSDSGDgseqp-----ggrqPDYRLMN--GGVLiPNGPR--GETPDSSSEeafsSa-pAPAKGQP-QRTPGTRERVRFSD 137
15_pfamImport  68 PSDSGDgseqqq---pqgrqPDYRLMN--GGVLiPNGPR--IGTPDSSSEeafsS---APSHKAQHQRTAGTRERVRFSD 137
18_pfamImport  68 PSDPGDcpepp----rpprpPPARLMN--GGVPvANGPRggGGTPDSSSEecfgS---AAVPKMPAQRPAGTRERVRFSD 138
6_pfamImport   71 PPSSLLciss------lrigALPRVVRaiGGVPiANGPR--GGTPDSSSEea-----fAPQQKGPHHRTAGTRERVRFSD 137
2_pfamImport   68 PSDQGDgpdpprpqpppcrqPDYRLMN--GGVPiANGPR--GGTPDSSSEea-----fVPQQKGPHHRTAGTRERVRFSD 138
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123888017  181 KILYHALCCDDDEDEDEDedgrdeeEDK-----LDTDSERSPLAGSPVPPLpelyncreppagGSHTIPRKDALNPgcrk 255
17_pfamImport 139 KVLYHALCCDDEEEDGEE-------VVAeeevgLSPEPPRPEAHVGPLKPS------------PAPYKPRRSPLTGrrps 199
5_pfamImport  139 KVLYHALCCDDE-GDGEE-------EAAeeeadLSPEPPRTEAPAGPPKPA------------PAPYKPRRSPLTShrsg 198
10_pfamImport 136 KVLYHALCCDDE--------------TEeeagsLPPELPHTEPHEGALKPS------------APLYKTRRSPLTSrrsg 189
9_pfamImport  142 KVLYHALCCDDEEGEGEE-------EQEedgaaPSPNPPQTEPHVAPLKPL------------LATCKPRRSPLTSrngg 202
4_pfamImport  138 KVLYHALCCDDDEEG----------EQGee-------------------------------------dgEESPLPSrhvh 170
15_pfamImport 138 KVLYHALCCDDD--------------EEadsspLPEDPPEEASDPAHKAGQ------------VTKTLPRRSPqqqkl-- 189
18_pfamImport 139 KVLYHALCCDDD-------------GDAdagadAPDDPARKG--------------------------PREQLLRNpgti 179
6_pfamImport  138 KVLYHALCCDDD-------------GDGadeasPNEDSTEER---------------------GLKVTPKNQPsvggngg 183
2_pfamImport  139 KVLYHALCCDDD-------------GDGadeasPNEDSTEER---------------------GLKVTPKNQPpvggngg 184
                         250       260       270
                  ....*....|....*....|....*....|...
gi 123888017  256 kl-------------lrnssTQTVSDKSTQTLL 275
17_pfamImport 200 stlape----qtrrvtrnssTQTVSDKSTQTLL 228
5_pfamImport  199 ptvape----qtrrvtrnssTQTVSDKSTQTAL 227
10_pfamImport 190 ptlape----qtrrvtknssTQTVSDKSTQTVL 218
9_pfamImport  203 hiptltpgsgqtrrvtrntsTQTVSDKSTQTVL 235
4_pfamImport  171 laptltvg-gqprkvtrnssTQTVSDKSTQTAL 202
15_pfamImport 190 ---------------trnssTQTVSDKSTQTVL 207
18_pfamImport 180 pir----------ratrnssTQTVADKSTQTLL 202
6_pfamImport  184 gttgg----pparrlmrnssTQTVADKSTQTVL 212
2_pfamImport  185 gtagg----pparrlmrnssTQTVADKSTQTVL 213
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