Conserved Protein Domain Family
GTSE1_N

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pfam15259: GTSE1_N 
G-2 and S-phase expressed 1
This family is the N-terminus of GTSE1 proteins. GTSE-1 (G2 and S phase-expressed-1) protein is specifically expressed during S and G2 phases of the cell cycle. It is mainly localized to the microtubules and when overexpressed delays the G2 to M transition. the full protein negatively regulates p53 transactivation function, protein levels, and p53-dependent apoptosis. This domain family is found in eukaryotes, and is approximately 140 amino acids in length. There is a conserved FDFD sequence motif.
Statistics
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PSSM-Id: 317641
View PSSM: pfam15259
Aligned: 28 rows
Threshold Bit Score: 113.543
Threshold Setting Gi: 390360526
Created: 29-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556953190    6 VTFITEEEFDFGFSFSNswedECD---Et---EDEIFVGPVKHLERCVAKSIDIN--IGNNESQRNNECLTNWSPPTADK 77
gi 768930012    9 LFFLHEEKFDFDMSMSPa---SSN---Gd---EDEVFVEPVGRNERCVSVNV--------KTQLDGRQLRTSWSPLTGDQ 71
gi 941821274    8 LCFLQDEKFDFNVSLSPv---SSKgeeEd---DDEVF---VGHTEQCVSTDV------SSQPEEGGGDVQAVWTPLTADQ 72
gi 765169223   28 VLFLQDEKFDFDVSLSPa---SSK---Dd---EDEVFEGPVEGEESRVSVS-------KASELLEGDHVFSNWSPLTGER 91
gi 1033407015   1 ---------------------S----------DDEVFVGPMGHKEKCIAVLLE-SqeGPKNKCSPSAQDAPTWSPLAGEK 48
gi 733868291   29 FPLLADEKFDFDLSLSPs---SGS---E-----DEVFIGSLGHKEKCIAVNIE-AksAEKKK-VPTSDDKLTWSPLIGDK 95
gi 823454049   22 FPLLSDEKFDFDLSLSSt---SGN---E-----DEVFVGPMGHKERCIAASIE------AKKCVSAFDDKLTWSPLQGEK 84
gi 514706469   30 IPLLTDEKFDFDLSLSPa---SGN---E-----DEVFVGPLGHKEKCIAVSIEAKrsTEKSE--PASDEKLMWSPLTGEK 96
gi 542231473    9 VFFLPDEKFDFDVSLSPa---SSR---Gde-dEDEVFVGPVSHKEKCISVSV--------ASPLENHSI--TWSPLTGEQ 71
gi 528521452    9 FVSLAEEKFDFDVSLSPg---SSK---GdyevEDEVFVGPVSHKEKCISHGV-EThmKDNISSGPSLGEEPSWSPLTGEK 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556953190   78 LEEITREANQLAAQLEk---C-----TlkEKENSYRQKNDGSITNSFKFEKDTKGKIRLLKEERENRKSPrsPRRETYIV 149
gi 768930012   72 LEAVCQEAHKLANQLQsgerS-----QshSEDDKDNEATAAVTTQPDEFVQDSQAKLHVFEQSNR-VLSP--IKRETFCV 143
gi 941821274   73 LEAVCEEAHRLASQLQ----CrephvQktNTTHTASDVDMNSMATTEEFIQDTEVKLGLLDHTAS-SLSP--IKRQTFCV 145
gi 765169223   92 LDAVCQEAHSLVNQLQ----------------DGKACGVEDANIAGEQFLQDSEAKKKVLC-SSSGALSP--IKRQTFCV 152
gi 1033407015  49 FVEIFKEAHLVALQLQ----S-----AskTKRKNAGQQEEAKSATVEKFVQESKSKLKILERGIVTNKTPtsIKRETFYV 119
gi 733868291   96 FVEIFKEAHLLALQIE----S-----GnkSEENKVSQSEGNGNETSEQFVEDLKSKMKILKSHHI-EKSPraVKRETYCV 165
gi 823454049   85 FVEIFKEAHLLALQIQ----T-----GskDEETKISQSEEQENKIIETFVEDSKSKLKILRNKNI-EISPrpAKRDTYCV 154
gi 514706469   97 FVEIFKEAHLLALQIE----R-----GskTEQDKISQAEEQEKEIIEKFVEDSKSKLKILRNENI-EQSPraAKRETYCV 166
gi 542231473   72 LEAVCQEAHRLASQLQs---T-----VshDENRDTTSMTMDTMTEQEEFVEDAETRLGLLAQTTS-GVSP--NKRQTFCV 140
gi 528521452   82 FDEICKEAQQLASHIEq------------TITDSAAESSVVSSCQTETFEDDAATKLNLFSKPAD-ILSP--IKRETFLV 146

                  ...
gi 556953190  150 KDS 152
gi 768930012  144 QES 146
gi 941821274  146 QDS 148
gi 765169223  153 QDt 155
gi 1033407015 120 AES 122
gi 733868291  166 GDS 168
gi 823454049  155 QDS 157
gi 514706469  167 WDS 169
gi 542231473  141 QDS 143
gi 528521452  147 QDS 149
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