Conserved Protein Domain Family
DUF4592

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pfam15262: DUF4592 
Domain of unknown function (DUF4592)
This protein family is a domain of unknown function, which lies to the N-terminus of the protein. This domain family is found in eukaryotes, and is typically between 114 and 130 amino acids in length. There are two completely conserved residues (L and A) that may be functionally important. In humans, the gene that encodes this protein lies in the position, chromosome 2 open reading frame 55.
Statistics
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PSSM-Id: 317644
View PSSM: pfam15262
Aligned: 25 rows
Threshold Bit Score: 65.9352
Threshold Setting Gi: 0
Created: 29-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
20_pfamImport    1 PTMKLGP----------PPPFgLHAKRTDDAGTSS-EDDGLPR--------------------------SPPEM----SL 39
19_pfamImport    1 KNIKFGQ----------PPQMtVSARTMGEANASA-EDDALLS--------------------------SPMET----ET 39
7_pfamImport     1 KNIKFGQ----------PPPKaVPMKKADSGEASL-EEDLFLT--------------------------SPMEI----VT 39
5_pfamImport     1 KNIKFGQ----------HPPSaIPMKKADSGEPRF-EEHPFLT--------------------------CPVES----VP 39
8_pfamImport     1 GNIHFGL----------RPDS-IPRKRMQGLGASTgEMDTSHI--------------------------SPMEIggwnLS 43
12_pfamImport    1 QGIKFGQ----------RP---PSLRKSEEDEGST-DEDEAPQ--------------------------SPLKV----LA 36
15_pfamImport    1 QGIKFGQ----------RP---PSLRRSEGDEGSS-DEEEVPR--------------------------SPLKV----LA 36
11_pfamImport    1 ------------------------SKITEDPGHQK-PDQPLHRklplstkvitpnarvvnrikcylkaeTPPKTekknVI 55
17_pfamImport    1 SKITEIPplrprqpsisPPLI-RSGTISKDLEEMS-GDDELPM--------------------------NPQMK----AS 48
gi 664708117    45 KNIKFGQ----------PPPKaVPMKKADSGEASL-EEDLFLT--------------------------SPMEI----VT 83
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
20_pfamImport   40 LHESLISgmrtRFSDSHKHLSSLSLAGTGSEEEEQitLGSSSRSRSTDgqlftrhgstSTESPrtst--dstISPTaNFD 117
19_pfamImport   40 QQDTVISdcsnKSTDTPDFLRKMNFLGPGHEMEEK---------VTPV----------KSARPkrqfscsgtIETI-NLD 99
7_pfamImport    40 QQDIVLSdtenKSSATPSSLSPLNLPGARSEMEEK---------VVPV----------KPSRPkrhfssagtIESV-NLD 99
5_pfamImport    40 EQALVLVdtesKPSETPGTPSPLNLPAARSEMEEK---------AAPV----------KPSRPkrlfssagtIESV-NLD 99
8_pfamImport    44 QGNTQNTdtgsNQQRSPSSFSSMNNIELEHKTEEK---------VTPV----------KPSRSkrpfavsgtIESI-NLD 103
12_pfamImport   37 QVEPEPSntesKDVSCDSTPYAIELKVYGTQQVEP--------HSTPV----------KSPRTkcalpptgtIESI-NLD 97
15_pfamImport   37 QVEAEPLrtepKKTHTHTH--------TKKKQVQG--GQPFGPHSPPV----------KSPRSkrvlpltgtIESI-NLD 95
11_pfamImport   56 HKILWSAlnisKPSPGPDQSQSLTALGTTAPSSTQ-----------PAt----------------------------TFI 96
17_pfamImport   49 SHKILAAkknySEATTGTGLSQSSTACASSNVTQQ-----------PV-----------------------------GFS 88
gi 664708117    84 QQDIVLSdtenKSSATPSSLSPLNLPGARSEMEEK---------VVPV----------KPSRPkrhfssagtIESV-NLD 143
                          170       180
                   ....*....|....*....|....*....
20_pfamImport  118 TPPELSAFLDNSAAKHKLLIKPRNQRFSR 146
19_pfamImport  100 SVPQALARLDNSAAKHKLSVKPKKQRMSR 128
7_pfamImport   100 AIPLAIARLDNSAAKHKLAVKPKNQRVSK 128
5_pfamImport   100 AIPLAIARLDNSAAKHKLSVKPKNQRVSR 128
8_pfamImport   104 AVPRSVDRLDNTFAKHKLSVKPKNQRVSK 132
12_pfamImport   98 ALPQSAPRLDNAAAKHKLSVKPKNQRISR 126
15_pfamImport   96 AVPQSVPRLDNAAAKHKLSVKPKNQRVSR 124
11_pfamImport   97 SSATQQVCLDSSAARHKIALNPRKQKKKK 125
17_pfamImport   89 IPATTQGCLDSSAARHKMALNPRKQKKKK 117
gi 664708117   144 AIPLAIARLDNSAAKHKLAVKPKNQRVSK 172
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