Conserved Protein Domain Family
TSSC4

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pfam15264: TSSC4 
tumor suppressing sub-chromosomal transferable candidate 4
This family of proteins is expressed from a gene cluster where in humans the TSSC4 gene is not imprinted. This same cluster is associated with the Beckwith-Wiedermann syndrome. This domain family is found in eukaryotes, and is typically between 120 and 147 amino acids in length. There is a conserved YSL sequence motif.
Statistics
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PSSM-Id: 317645
View PSSM: pfam15264
Aligned: 16 rows
Threshold Bit Score: 116.427
Threshold Setting Gi: 110748711
Created: 15-Apr-2017
Updated: 23-May-2017
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122134285  90 HSIFDGLEGAARRAVPAv-------TPASPGD------------------------------------------------ 114
gi 556977924  96 QSIFEGLENPTRLSLPT--------LNNNSDEeed-------------------------------------------vi 124
gi 242021724  26 RNLFDILDSAEKEKKS---------CDNSCNDsmdidvnksssr------------------------rqrkitkqfrgq 72
gi 612061909  90 HSIFGGLEGAAGLTGIPi-------ADPQPDGdr---------------------------------------------d 117
gi 195126194   9 DALFACLDDASKELKGTa-------LDQSKSKpytvvalekaknrnpvmnyrq------grsieagnevedgklrrmrgk 75
gi 195376681   9 DALFACLDDASKELKGTp-------LDQSRAKpytvsaleranntknrnqvmnyr---qgrsievgndvedeklrrlrgk 78
gi 195012737   9 DALFACLDDASKELKGTa-------LDQTRSKpytinaleraknqgrkicaa--------gkadlvetetdeklrrlrgk 73
gi 110748711  21 KLLFDKLSDAEQECNKNkivnepmdMDSNIEQsnyfqilkagr---------------------------qsqtrrfrgk 73
gi 195428271   9 DALFACLDDASKELKGTg-------LDQSKAKpytiramerrhnarddrgqvmnyrcgqriqvdgetesedgklrrmrgk 81
gi 9938004    91 HSIFDCLESAARQAPCSa-------PQTSVSD------------------------------------------------ 115
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122134285 115 GGGFQQLLT-PSSQPAAGVPGRAAGSPAAQRAPPVPDYVTHPERWTRYSLDDVA--EASEQSNRAAALAFLG-------- 183
gi 556977924 125 DGPFKRPLPqPAPRRAAGDAAAGKRRIVGKKVSAVPDYVAHPERWTKYSLEDVE--ETSDRKNKMVALEFLEglqksrek 202
gi 242021724  73 ESLFNKPLS-LPPRFKKRNK--------------VPDFQRNPHKWTKYSLGDVTqnEMSNETNTAAAMSFLR-------- 129
gi 612061909 118 DGPFKR-----------PLPPPGPAPHRPPSRPQLPDYVTHPERWTKYSLEDVP--DASDCTNRAVALEFLG-------- 176
gi 195126194  76 ESIFKKPEL-PIGRCLKPRK--------------TPDYQVNPHKWKKYSLSDV---DISDQTNAAAALSFL--------- 128
gi 195376681  79 ESIFKKPEL-PIGRCLKPRK--------------TPDYQINPHKWKKYSLSDV---DISDQTNAAAALSFL--------- 131
gi 195012737  74 ESIFKKPEL-PIGRCLKPRK--------------TPDYQVNPHKWKKYSLSDV---DISDQTNSAAALSFL--------- 126
gi 110748711  74 ESIFKRPEG-PAPRALNRS---------------IPDFHKNPHKWKKYSLDDVsndDMTEESNTRAALSFL--------- 128
gi 195428271  82 ESIFKKPEL-PIGRCLKPRK--------------TPDYQVNPHKWKKYSLSDV---DISEQTNSAAALSFL--------- 134
gi 9938004   116 NGSFRRPVT-PPSQTPARGLsrvhgntgptrvlpVPDYVSHPERWTKYSLEDVs--EASEQSNRDAALAFLs-------- 184
                        170       180       190
                 ....*....|....*....|....*....|
gi 122134285 184 P-------QNLAAPGNYMPSFNQDPSSCGE 206
gi 556977924 203 K-------MSLDIDKSFVPCFNQGLSSSAE 225
gi 242021724 130 D-------IEIQKLKTRVKMEVDDSNDCKS 152
gi 612061909 177 DlkrraggQSPAPPESCAPSFNQDPSSRGA 206
gi 195126194 129 --------RQMDAQRDADSDGTDDMDETGT 150
gi 195376681 132 --------REMDSQRDVDSDDTEDMNDAGT 153
gi 195012737 127 --------REMDAQHGQTDPADEMDNEPST 148
gi 110748711 129 --------KELKARRSLEKLKQSEKIDine 150
gi 195428271 135 --------REMDAQRETDTIGQDDDELASS 156
gi 9938004   185 -------sRSQVSHTDYVPSFNQDPSSCGE 207
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