Conserved Protein Domain Family
DUF4594

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pfam15266: DUF4594 
Domain of unknown function (DUF4594)
This protein family is a domain of unknown function. The protein family is found in eukaryotes, and is typically between 170 and 183 amino acids in length.In humans, the gene encoding this protein lies in the position, chromosome 15 open reading frame 52.
Statistics
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PSSM-Id: 317647
View PSSM: pfam15266
Aligned: 25 rows
Threshold Bit Score: 125.267
Threshold Setting Gi: 444730785
Created: 29-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158513399  187 QARSPRAKGTSGGGRSWRAPLQMTSSSDSAGK-G--------VLEPRSPGV-----VsSpPP-QQSLGLspeASWDYTQW 251
gi 555978126  301 EPERDRREGSRRHGRNWGGPDFERVRYGLEQErQ--------G------GGrraglS-GaGDmTLSMTGr--ERSEYLRW 363
gi 731459457  207 EPERDRREGSRRHGRNWGGPDFERVRCGLEQErQ--------GRR---AGL-----G-GaGDmTLSMTGr--ERSEYLRW 267
gi 444730785  206 EPERDRREGSRRHGRNWGGPDFER------------------GRR---AGL-----G-GaGDmTLSMTGr--ERSEYLRW 256
gi 612025997  215 ESERDRREGSRRHGRNWGGADFERVRSGLEQErY--------GRR---AGP-----G---GDmTLSMTGr--ERAEYLRW 273
gi 1033385670 233 fAETDRREGSRRHIRNWGGPDFDKVKTGIEQGkEwpspgrggSRRRGGPPP-----A-AsLDmTLCMTGr--ERAEYIRW 304
gi 847157420  302 EV--DRKEGSRRHNRNWGGPDFEKVKTGMDKEkEs------hGRR---PAM-----K-DqMDmTMSMTGr--ERAEYVRW 362
gi 941796020  264 DI--DRKEGSRRHVRNWGGLDFDNVKTGHELErEw------tSRR---PGP-----KgGsVDmTMSMTGr--ERAEYLRW 325
gi 768932802   38 DT--DRKEGSRRHVRNWGGLDFDNVKTGPELEkEw------sSRR---SGP-----K-GsVDmTMSMTGr--ERAEYLRW 98
gi 832626498  247 DT--DRKEGSRRHVRNWGGVDFDNVKTGPEVEkEw------tNRR---PGG-----K-GsVDmTLSMTGr--ERAEYLRW 307
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158513399  252 KQEREQIDLARLARHRNPQGDWSRPWDLDKAKSMPQNCHK----PRDRDLA-MG--SRKGprtHQKPQHPPSSLDGK--C 322
gi 555978126  364 KEEREKIDQERLQRHRKPTGQWRREWDAEKTDGmFKDGPA----VALEPSHrYDdqAWAR--------PPKPPTFREflS 431
gi 731459457  268 KQEREKIDQERLQRHRKPTGQWRREWDAEKTDGMFKDGPA----PAVETSHrYDdqPWAR--------PPKPPTFGEflS 335
gi 444730785  257 KQERERIDQERLQRHRKPTGQWRREWDAEKTDGMFKDGSThvhePFNEPSPrYDeqAWAR-----PPKPPKPPTFGEflS 331
gi 612025997  274 KQERERIDQERLQRHRKPTGQWRREWDAEKTEGMFKDGPS----TASEPPAhHDegSSR---------PPKPPTFGDflS 340
gi 1033385670 305 KQEREQIDQERLARHRQPTGEWRREWDAEKMDAAFKEGSK----PGSSGGSgGGkhGESK-------RPPKLPTFGEflS 373
gi 847157420  363 KKEREQIDQERLARHRKPTGQWRREWDAEKTDSMFKDGGS----PRVEDEPvSRreKGKR-------GAPKPPTMGEffP 431
gi 941796020  326 KKEREQIDEERLARHRNATGQWRREWDAQKTDGMFKEDPN------VAAEGvTAeeGGRR---DDSKRPPRGPTFGDflS 396
gi 768932802   99 KKEREQIDEERLARHRNATGQWRREWDAQKTENMFKEDTC------ASTESgTPeqSGKR---DDNKRPPKGPTFGDflS 169
gi 832626498  308 KKEREQIDEERLARHRNATGQWRREWDAQKTDTMFKEESA------VAGES-MQeqSNRR---EDNKKPPKTPTFGDflG 377
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 158513399  323 rggqSGRPSMtSTIGSNAQGKERLTGRAR-------RYDMK-EDEM 360
gi 555978126  432 ----QHKTEV-SR-RKKKSSRPQPKAAPRaysdhddRWEMK-Eavs 470
gi 731459457  336 ----QHKAEVnSR-RRRKSSRPQAKAVPHaysdhddRWETK-ETas 375
gi 444730785  332 ----QHKAEVsSR-RKRKSSRPQAKAAPRaysnhddRWEMK-EETa 371
gi 612025997  341 ----QHKTVPgNR-RRRKTSRPRVKGPPRgyshhddRWEPK-EEVE 380
gi 1033385670 374 ----EQQPDRrRRGRGRGRGRPRGSGPSKpysmhdnRWEKE-EPdq 414
gi 847157420  432 -----GNIMEsNRKRDRQRGQ----GQNKpysmhdtRWEEPxEDKE 468
gi 941796020  397 ----QGRSQGpRGDRSRGRGR----GQRQsysmhdnRWEGE-KEEE 433
gi 768932802  170 ----QGRTPGsRGDRGRGRSR----GQKPeysmhdnRWEGE-KEQE 206
gi 832626498  378 ----QGKPR-----QAGGRGR----GKGKsysmhdnRWEGE-NEEE 409
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