Conserved Protein Domain Family
SOBP

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pfam15279: SOBP 
Sine oculis-binding protein
SOBP is associated with syndromic and nonsyndromic intellectual disability. It carries a zinc-finger of the zf-C2H2 type at the N-terminus, and a highly characteristic C-terminal PhPhPhPhPhPh motif. The deduced 873-amino acid protein contains an N-terminal nuclear localization signal (NLS), followed by 2 FCS-type zinc finger motifs, a proline-rich region (PR1), a putative RNA-binding motif region, and a C-terminal NLS embedded in a second proline-rich motif. SOBP is expressed in various human tissues, including developing mouse brain at embryonic day 14. In postnatal and adult mouse brain SOBP is expressed in all neurons, with intense staining in the limbic system. Highest expression is in layer V cortical neurons, hippocampus, pyriform cortex, dorsomedial nucleus of thalamus, amygdala, and hypothalamus. Postnatal expression of SOBP in the limbic system corresponds to a time of active synaptogenesis. the family is also referred to as Jackson circler, JXC1. In seven affected siblings from a consanguineous Israeli Arab family with mental retardation, anterior maxillary protrusion, and strabismus mutations were found in this protein.
Statistics
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PSSM-Id: 317654
View PSSM: pfam15279
Aligned: 17 rows
Threshold Bit Score: 211.558
Threshold Setting Gi: 157265543
Created: 29-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 162416114  255 VCDWCKHIRHTKEYLDFGAGERRLQFCSAKCLNQYKMDIFYKETQAALpgglCNPPLPTSDTKSesgAGv---------- 324
gi 1036994401 248 TCDWCKHVRHAVSYVDFQDGASQLQFCSEKCLNQYKMQIFCNETQAHL----DMNPHLRDQGLE---AGse--------a 312
gi 357614216  137 TCDWCRHVRHTVAYVDFQDGATQLQFCSDKCLNQYKMHIFCRETQAHL----DLNPHLVNAASS---S------------ 197
gi 968076205  245 TCDWCKHVRHAVSYVDFQDGASQLQFCSEKCLNQYKMQIFCNETQAHL----DMNPHLRDQGLD---AGne--------a 309
gi 170036333  105 TCDWCRHVRHAVSYVDFQDGVTQLQFCSDKCLNQYKMQIFCNETQAHL----DMNPHLKEKSTS---AGs---------- 167
gi 321468092  141 VCDWCKHVRHTVSYVDLHDGQRQLQFCTDKCRNQYKMRLFVAEAS-SLgvqsCATPGSKGET-S---PGtsidlkkqstg 215
gi 242009685   37 TCDWCRHIRHTVNYVDFQDGEHQLQFCSDKCLNQYKMNIFCKETEAHL----QLHPHLQGLGSS---GGsngkg--nasv 107
gi 195582528  273 TCDWCKHVRHAVSYVDFQDGASQLQFCSEKCLNQYKMQIFCHETQAHL----DMHPHLRDQAMD---AGse--------a 337
gi 195380948  240 TCDWCKHVRHAVSYVDFQDGASQLQFCSEKCLNQYKMQIFCNETQAHL----DMNPHLRDQGLEaaaAGdg--------a 307
gi 158300896  218 TCDWCRHVRHTVSYVDFQDGASQLQFCSDKCLNQYKMQIFCNETQAHL----EMNPHLKEKSTS---AGkvt-----glr 285
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 162416114  325 QLLTPESWsapLSELRsRKAPSPVGATIAGPSG--S--------TSGSPSEAGt----VCSSSSSSSSSSSSTKIPTPRP 390
gi 1036994401 313 GLITPDLW---LRNCR-SRSASPASTVSVSPGPpaErsag-ataKRISPSVTP-----PSNPSKPLISVAPVSKLLAQKS 382
gi 357614216  198 NLITPELW---LKNCR-SRSISPTSEGSGTPNDk-N--------DDTCQRKSPl----------PLITIAPPAKLMNPKP 254
gi 968076205  310 ALITPDLW---LRNCR-SRSASPAST--VSVSPgpI--------KRNSPCATP-----PSNPTKPLISVAPVSKLLALRS 370
gi 170036333  168 -LITPDLW---LKNCK-SRSASPLSDRSESVSPapSl------pMRPSPEPSPvm--qSSPAKKPMISVAHPSKLLSKNL 234
gi 321468092  216 ILITPDLW---LSDC---QLDNPINVKLECNEE--T--------ELASIDSEPe----EQNCEIPLNLVHSSRRSVQPVK 275
gi 242009685  108 RLITPELW---LRDC---RSESPISDRSLSPQ------------DNNNSSSSPi----E---IKVVMRPPNENSQLTVKP 162
gi 195582528  338 GLITPDLW---LRNCR-SRSASPASTLSVSPGPppAp------aVSRCPDSPP-----SHHPSKPLISVAPVSKLLAQKC 402
gi 195380948  308 GLITPDLW---LRNCR-SRSASPAS--TISVSPgpAavcianasKRSSPCNTP-----PSHPNKPLISVAPVSKLLAQKS 376
gi 158300896  286 TLITPELW---MKNCK-SCSISPVSDRSESVSPvpSl------pVRSSPEPSPvllrsPTPAKKPLISLAPASKLLS-KS 354
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 162416114  391 HESP-----------SLPPPHpp---------------pISGLHPALGMPPGSPPMVMTPRG---P-------------- 427
gi 1036994401 383 PAPA-----------AAVPPPppppqqrhhnslgsgpglKPGRRKRPQRGPSSSSGSETVAS---Mlqkqhhqq-----q 443
gi 357614216  255 PEDR-----------PVQKSPetkkd---------lrtkMNLRKRRTSKCSTVTSQTVRQRS---Itpkt---------- 301
gi 968076205  371 PQAAqasqpppppqtSLHQQRqqhq----------nltsKSGRRKRLHRG-GLSAGSETVASllqKqqqh---------- 429
gi 170036333  235 QPSA-----------AVNARTviks----------trkrRPGLRPLQQNTLHNRKNAKVDYG---Qltsnn--------- 281
gi 321468092  276 RKPN------------LVEIPlskk----------gkshRK-----HHSSSHQHKTSIYTRN---Lippp---------- 315
gi 242009685  163 SPPP-----------SLTPSTleitk---------vdrkERGTHREKSRKTGSILSKSKRQG---Rygsgn--------- 210
gi 195582528  403 PGPG-----------PGVPPPppppv---------qrhlAGKLGRRKRRGISSSSGSETVAS---Llqkqqqhhqqqqap 459
gi 195380948  377 PASS-----------SITTGApppplpqlq-rhhvhagpKPGRRKRPHRAAG-AAGSETVAS---Llqkqq--------- 431
gi 158300896  355 LQPS-----------TLPTRPspks----------srkrRTGHRPPPGTNASMSSGKRST-------------------- 393
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 162416114  428 ------VPFPIFMEHQMmqqMRPPFLRPPG-----P-------NSPHSNPMIP------GIGPPP--------------- 468
gi 1036994401 444 qqqqhqPTLSADFSGSS---VPLPPLSPMPep-ahP-------HQQQQQPPTVvppqvlGRGPTAi-------------- 498
gi 357614216  302 ---qdfRMLSPSMDGSS------PASCVTSnn-pvH-------SPPHMNQPIP------PPFPNPmf------------- 345
gi 968076205  430 ---hqpSPISADFAGSS---VPLPPLSPMPmp-eqSappppaaAPPTPTQSLG------RGCATAi-------------- 482
gi 170036333  282 -nnnnaSVLNNNLPASS---MPKPATVTSAni-qdL-------RAGISLQNLT------HSLTPTkfesrespttprppp 343
gi 321468092  316 ---pptLPCPATTWPS----FPYPPHMVPSyi-lqS-------QFLALNRSLK------P-------------------- 354
gi 242009685  211 -nerrgSSLSPRNRENL---TPPKPNIFPPsf-fpL-------NGTSLPTMHP------PHPAPPp-------------- 258
gi 195582528  460 qqhqapPTLTADFGGSS---VPLPPLSPMPsmqeaP-------QQQQAPQVPP------TQVPPRgpt------------ 511
gi 195380948  432 -qqqqpAPLSADFAGSS---VPLPPLSPMPdq-pqP-------QQQHQQ-HPP------PQLPQPmgrp----------p 482
gi 158300896  394 ------VTHQAEYGGSA---------GASSsinnnN-------NVTIPNNNLL------TAVLNI--------------- 430
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 162416114  469 ---PPRTLCPPSSPM-HRPLLSPHlhpsSTPTLSGNPPgiMPPHPAa--hMP-----GL------------PFPpvnMmp 525
gi 1036994401 499 ---PSSYFAPPPNGHpMGLPFGRHp--aQPPHHFLPp--pHGMMPRg--fPPp---fGL------------PMP---T-- 549
gi 357614216  346 -gmPPPVFMDSNHMNdHRNPMFQ------PRVNFMPPPgmHQERPRl--fPPln--fHQ------------PINqapP-- 400
gi 968076205  483 ---PPSYFATPPNGM-LGHPFGVRp--pHHFLPp-----pPGMLPRg--fIPp---fGP------------PPPfatP-- 532
gi 170036333  344 lniPPQFLQLPPNPA-MRPPFFPL----NPAFRFGs---pPNPQAMp--pPPp---pNM------------DPNnpqN-- 396
gi 321468092  355 ---PKNPCVRSTDRE-DQISFTPVi--eSNKMPSEPVI--EQSSTKv--aTPpdertAE------------AINeltE-- 410
gi 242009685  259 ---PPHNGMPPDHGL-LKPPFLPLgcfpPPPPPPPPPPppPPTGPRn--fQRp---gGQihhrpplisppsPSGptvI-- 327
gi 195582528  512 -aiPASYFATPSNGVpMGHPFAGRpp-pPPHHFMHPPP--HGMMPRg--fGPh---fGP------------PLPp----- 565
gi 195380948  483 agmPGGYFATPPNGM-LGHPFGARaa-pPPPHPFLPPP--PGMLPRg--fGAh---fGP------------PPPpqlQp- 540
gi 158300896  431 ---PPQFLPPPLNL--LRAPFFPLn--pAQLRFPAGLPnlPNAQPPpappPPpp--mGP------------PPSplaGgp 489
                         410       420       430
                  ....*....|....*....|....*....|..
gi 162416114  526 sgpipVPPIMNIGMPslaplVPPPTLLVPYPV 557
gi 1036994401 550 -----QVPEHLGAFAammgaVPPVTVMvpypi 576
gi 357614216  401 -----Vtvlvpypvvipvpipipiplplssfi 427
gi 968076205  533 -----QMPEFGll-----gtAPPVTVMVPYpi 554
gi 170036333  397 -----RHQPPLLGFP-----APPVTILVPYpi 418
gi 321468092  411 -----NKQEINH-TKlltpeIPPNFVVLRIPY 436
gi 242009685  328 -----NKPIRNPLLPpprslLPPVTVLVPYPV 354
gi 195582528  566 ---------qMPELGsllgaVPPVTVMVPYPI 588
gi 195380948  541 ----qLQPELQGALGallgaAPPVTVMVPYPI 568
gi 158300896  490 lggptGSRPPLPNLLgfggaAPPVTILVPYPI 521
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