Conserved Protein Domain Family
RFXA_RFXANK_bdg

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pfam15289: RFXA_RFXANK_bdg 
Regulatory factor X-associated C-terminal binding domain
This C-terminal domain of Regulatory factor X-associated protein binds to RFXANK, the Ankyrin-repeat regulatory factor X proteins. RFXA is part of the RFX complex, Mutants of either RFXAP or RFXANK protein fail to bind to each other. RFX5 binds only to the RFXANK-RFXAP scaffold and not to either protein alone, and neither the scaffold nor RFX5 alone can bind DNA. The binding of the RFXANK-RFXAP scaffold to RFX5 leads to a conformational change in the latter that exposes the DNA-binding domain of RFX5. The DNA-binding domain of RFX5 anchors the RFX complex to MHC class II X and S promoter boxes.
Statistics
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PSSM-Id: 317663
View PSSM: pfam15289
Aligned: 7 rows
Threshold Bit Score: 129.224
Threshold Setting Gi: 350646362
Created: 29-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350646362  27 SCLSTSTTETENGSKLQRV-SGSTKNSKTSASSVKTH-AKSSgvrgrksissDEMANRKRqefnelvkarTE-------- 96
gi 410915812  92 QCTYEGCTETSTQVAKQRK-PWMCKKHRNKMYKDKYK-KKKS----------DKAMSSTK----------LD-------- 141
gi 72043183   59 KCSVDNCQEMLVVSGKRRKgPWMCSYHRNK--TYKAK-KKQK----------DQMTTNIQ----------MF-------- 107
gi 513165616 153 SCTYQGCNETTTQVAKQRK-PWMCKRHRNKMYKDKYK-RKKS----------DQALGGGGaaaanagggpRA-------- 212
gi 984096640 188 TCTYEGCNETTSQVAKQRK-PWMCKKHRNKMYKDKYK-KKKS----------DQALNCGGatssgsagnvKL-------- 247
gi 301620537  97 SCTYQGCQETTSQVAKQRK-PWMCKKHRNKMYKDKYKnKKKN----------DQAISTASkl------------------ 147
gi 47227068   92 QCTYEGCTETSTQVAKQRK-PWMCKKHRNKMYKDKYK-KKKS----------DKAMSSTK----------LDvrrpeagv 149
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350646362  97 -------------------KLMSDGPIA---NATGSTGPESGSPNyr-kLIHAVLDAKKSALLRSPSVIHFLVSQQRSLT 153
gi 410915812 142 -------------------ENSEERPVSvnkQRLGAMGDRPARPT----LIEQVLNQKRLSLLRSPEVIRFLQQQQHFLA 198
gi 72043183  108 -------------------KKKEEENVPkpsSLQSIPGGEKSAPDdglpRLDQVLNEKKLALLRSPAIIKFLQESQQQLS 168
gi 513165616 213 -------------------EDCVEGTVSatkQRTGSIGDRPARPT----LLEQVLNKKRLSLLRSPEVVQFLQKQQQLLS 269
gi 984096640 248 -------------------EESPDNILSivkQRTGSFGDRPARPT----LLEQVLNQKRLSLLRSPEVVQFLQKQQQLLN 304
gi 301620537 148 -------------------eDNPECPISltkQRSSSVGDRPARPT----LLEQVLNQKRLSLLRSPEVVHFLQTQQQLLS 204
gi 47227068  150 nryqpapdadiclflfpvqENSEERPVSvnkQRLGAMGDRPARPT----LIEQVLNQKRLSLLRSPEVISFLQQQQQFLA 225

                 ....*
gi 350646362 154 EYKRQ 158
gi 410915812 199 TQTHG 203
gi 72043183  169 HTHHQ 173
gi 513165616 270 QQALE 274
gi 984096640 305 QQVLE 309
gi 301620537 205 RQALE 209
gi 47227068  226 TQNHG 230
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