Conserved Protein Domain Family
ALS2CR8

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pfam15299: ALS2CR8 
Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 8
This domain is found in amyotrophic lateral sclerosis 2 chromosomal region candidate gene 8 protein.
Statistics
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PSSM-Id: 317672
View PSSM: pfam15299
Aligned: 16 rows
Threshold Bit Score: 123.624
Threshold Setting Gi: 780124307
Created: 30-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 780124307  104 IETDHHKVCWE--DSsrLRQGH--LVFDYV----------------PYIVIGIK--M--LDCQ------YGKDRHIA--- 150
gi 459173619   63 WQKSSHFISFE--SE--RGNIR--IPFDGI----------------PFMVIGTK--V--LQCQ------HGKDSHKKske 110
gi 780178586   52 PDPGKSFLRFR--LD--YGGQSpkIECDGM----------------PFFYMHRH--V--LICH------QGKDRNEKtka 101
gi 780006303   44 aEKSSFRLRWE--YDedQHPCK--IPFTGV----------------PFIAVGRK--T--MECH------QGKDRNIRqke 93
gi 260825472  332 PGKPSTRLMWK--------SQY--VPFDGI----------------PFVNIGSRaiV--QECQ------FGPRRKGIvak 377
gi 260833424   60 QPSAKKSINWK--L------KY--VEFDGV----------------PFQLVSKA--V--YGCH------QGEDRDKPkkd 103
gi 156388881  202 sAKPSIRLMWK--------SQY--VPYDGI----------------PFLNTGRRatV--MECQ------YGPRRKGCiak 247
gi 699250576   73 KPSAKERIYWEhpLP--NGSVS--IPFDGF----------------PFMFVGRK--V--LLCQ------FGKDMEKDrrd 122
gi 260807469  388 rwaSAYIVKFDn-ME--RPGNL--MDFDKIeklksdpdmmfiltagPDDDVTNF--TgsAGCHfcwlftYGNSREAMirk 460
gi 242023590   85 QLPGRGSLMFK--SS---SDVS--VPFFGS----------------PFTVETTI--Y--YTCS------QGIKYYGSkqy 131
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 780124307  151 ------------------RKK----------------------------------RSLS--------------QVDINTV 164
gi 459173619  111 rykqmk----ergeyppsKKQ----------------------------------RTLTnptkk----kdcpaTIHLREV 148
gi 780178586  102 krkalvqfsnatnqestgRKK----------------------------------RKLVqdtkk----vdcpaSVYVVQI 143
gi 780006303   94 kyaiqae--ksrdsnskkRKK----------------------------------QMVSqrtkk----vscpaAIIIIQI 133
gi 260825472  378 ----------------kiGEQ----------------------------------EKNCkqgfk----atcpaRIYIKKV 403
gi 260833424  104 krkaekq--qqaledhgfLRR----------------------------------HRQVqdtkk----mdcpvKFTVHYL 143
gi 156388881  248 ----------------ksNEY----------------------------------EDESgqlkkph-rptcpaRIYIKKV 276
gi 699250576  123 krynele--rlrsvnpenYPK----------------------------------KRRRkqsik----igcpaTVNLVQI 162
gi 260807469  461 lvdvlklvlrlcevnargSKQlqgcyresyknanqdyvyltagrgvkyvtppqtgRWASayivkfdnmerpgnLMDFDQI 540
gi 242023590  132 pdem-------frqgdplSKK----------------------------------RRKPkitkk----igcqaRMTVKKI 166
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 780124307  165 --------------------------------------------------------------WRRKVMSEKLRKSLSMGS 182
gi 459173619  149 vtfpefq-------------------------------------------------mlkdtaRYRRKISCDIRTLLKNDP 179
gi 780178586  144 lrftdhkvq---------------------------------------------fqgleptgHSKVLVKRQLREEYQTDA 178
gi 780006303  134 trlqdik-------------------------------------------------vkenkeWTKRMAAAEFRKMLSKGH 164
gi 260825472  404 rkfpqfr-------------------------------------------------vhlredMDRKALRQAQERAFRSLK 434
gi 260833424  144 irfpdfk-------------------------------------------------ieedkqSAKDKVSKALKEALAKDP 174
gi 156388881  277 rkfpey---------------------------------------------------ridpnLEGKNVRQAQERALTTLR 305
gi 699250576  163 akfqsyky-----------------------------------------------hvaknskRQRRTAADKLRQDLLNGA 195
gi 260807469  541 lklksdpdvmfiltagpdddvtnftgsagchfcwlftygnsreamirklvdvlklvidkdtdARRRKASKDLKKAIDQKP 620
gi 242023590  167 kvfpsedy-----------------------------------------------lvsrnnwREKKVAIDQLKNDFLNNK 199
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 780124307  183 ---EV----KGERRIYIKFPEASDHNG------------------------HQ----------------------Infdv 209
gi 459173619  180 ---SKi---QMERRIYILLPFINEHRF------------------------HI----------------------I---- 203
gi 780178586  179 ---SCi---HTETLFYVSLPSLSSHRG------------------------HP----------------------V---- 202
gi 780006303  165 ---KPl---Q-RSEFYALFPKDQDHKG------------------------HP----------------------I---- 187
gi 260825472  435 ---ESglehGGEERQYVQLPTPEAHQF------------------------HD----------------------E---- 461
gi 260833424  175 ---SAv---KAVWEYRTRFPAMDDHRN------------------------HP----------------------T---- 198
gi 156388881  306 lagVEm---GGEERFYVQLPLPIAHEY------------------------HD----------------------T---- 332
gi 699250576  196 ---Ev----DVKMMFIKKASALSEHEG------------------------HLvcvent-----------lasarI---- 229
gi 260807469  621 ---SSv---QATVQFHTCFPTLTEHKN------------------------HP----------------------T---- 644
gi 242023590  200 ---Pv----ESINRYCIVISLDISHNHeaklkipkkpkqrqfdpakkvlklHEqfqeavvmlnselitkctnisiL---- 268
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 780124307  210 aedsvlhrpdserialrimgdlhgatdgSG---------S-RSEI----Hsdkdqhqepqetpiniefaeqdlghqahla 275
gi 459173619  204 ----------------------------GQ---------C-NPNL----K------------------------------ 211
gi 780178586  203 ----------------------------NN---------I-AAGL----R------------------------------ 210
gi 780006303  188 ----------------------------RN---------E-AAGL----R------------------------------ 195
gi 260825472  462 ----------------------------IQdhvladfsvC-NMEA----S------------------------------ 478
gi 260833424  199 ----------------------------VG---------M-VAEL----S------------------------------ 206
gi 156388881  333 ----------------------------DD---------VpMATL----Edq---------------------------- 343
gi 699250576  230 ----------------------------QG---------D-RNILafdcL------------------------------ 241
gi 260807469  645 ----------------------------VG---------E-VAEL----R------------------------------ 652
gi 242023590  269 ----------------------------TG---------C-CNSL----K------------------------------ 276
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 780124307  276 lsrqspetsrQKIDslpssqtrgdthqriqygrqmidspqsnqtsndinqaiqcrrqmidspqsnqtsgdtnqaiqcrrl 355
gi 459173619  212 ----------QNVD------------------------------------------------------------------ 215
gi 780178586  211 ----------EALD------------------------------------------------------------------ 214
gi 780006303  196 ----------EPTI------------------------------------------------------------------ 199
gi 260825472  479 ----------SRLH------------------------------------------------------------------ 482
gi 260833424  207 ----------QPVD------------------------------------------------------------------ 210
gi 156388881  344 ---------gQRLN------------------------------------------------------------------ 348
gi 699250576  242 ----------QETD------------------------------------------------------------------ 245
gi 260807469  653 ----------EGVD------------------------------------------------------------------ 656
gi 242023590  277 ----------SIINqlkdsia----------------------------------------------------------- 287
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 780124307  356 ldqlteetfsiqdSS--ILDALH--QQLE-GALRNVQRAK------QKRVGIPsRQSCtDT-MTPRPQRREpsdrctsct 423
gi 459173619  216 -------------PQ--LVEKIY--ELVNvSGVDSIDEMV------QLLKNFV-LEIF-VG-KKMPPVSNK--------- 260
gi 780178586  215 -------------PR--IIHKIA--ELTA-KGISKVPEIR------KHLDEYVqSALF-HS-TEQPERTRR--------- 259
gi 780006303  200 -------------PE--VVERVR--SLTR-GGIVKVSEMK------QHIVNFLhKELH-VT-DTL----RR--------- 240
gi 260825472  483 -------------PR--VSSKIR--ELVA-SGMNEVYQVR------KAVRKFVeKELF-GGsDTVPERHNL--------- 528
gi 260833424  211 -------------DR--IRQQVE--KITE-GGAKTVSEVK------HHLSTFItNELF-RG-ETPPPTTQR--------- 255
gi 156388881  349 -------------QQ--IISKIQ--EYVA-RGVTGLYAIK------HLLKEFVeKEMF-SG-QEAPPKHNK--------- 393
gi 699250576  246 -------------EMedLIKEIYdeKYLT-ELLIELRRFK------TCIKSFVhNAPIlQH-DQSDRKRKLpmelldkim 304
gi 260807469  657 -------------ER--VKGRIR--TLAL-NGVKDIREMR------RHLDAYVnDDLF-KG-QDLPPTTRR--------- 701
gi 242023590  288 ------redgvpiDL--ITAAID--KITQ-KQLKSAATLEkknlaaAKKKQFKtEKLI-KV-EPCEEINAN--------- 345
                         570       580
                  ....*....|....*....|...
gi 780124307  424 dtmTPKPQMREPSNRCTSCTDTM 446
gi 459173619  261 ---RFYPSKKDIREHMANAVAKL 280
gi 780178586  260 ---RYYPTDIDIRNTVQKAKKEV 279
gi 780006303  241 ---RYMPTNTDISNIMASVKRKa 260
gi 260825472  529 ---SYFPTVNDIQNHVHLAQMAI 548
gi 260833424  256 ---KYYPTDRDLWNIMAKVNDST 275
gi 156388881  394 ---AYFPTIIDIQNHMHQAQMAL 413
gi 699250576  305 kypRFSPPDRDLINNPGVFgqdf 327
gi 260807469  702 ---RYNPTDKDIRNNMDKSKDRI 721
gi 242023590  346 ---AFVAKVENNENQIIELSSVM 365
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