Conserved Protein Domain Family
LIN37

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pfam15306: LIN37 
LIN37
LIN37 is a component of the DREAM (or LINC) complex which represses cell cycle-dependent genes in quiescent cells and plays a role in the cell cycle-dependent activation of G2/M genes.
Statistics
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PSSM-Id: 317679
View PSSM: pfam15306
Aligned: 35 rows
Threshold Bit Score: 102.426
Threshold Setting Gi: 167537269
Created: 29-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121954309  64 SVGLRHQQGSS------FIMKLFDRSVDL--AQFDGEsslYPVCRAWMRNQPRarqnp-ydpkpSDPASPPRGAESSRHS 134
gi 74966827  112 STSLMESPRKTmtrdskIMFELRGKPFEMiaGRFEEE---YSLGRAWVKGHMNney-----epiKAQRTDYAPNLAVDYL 183
gi 121956081  58 SSESIPIPHQS------YIMKLFDRSVDL--ARFDETtplYPICRAWMQNQPR-----------VNPKQLRTPSPVKREH 118
gi 195057800 114 NQTGTKPHSES------YVMRLFDRSLDL--SKYEDKtplYPICRAWMANQPRnp-------nvAIYKTDGSVPIVKRED 178
gi 170044072  59 SAAIRHQHSST------FIMKLFDRSVDL--ARFPEAtalYPVCRAWMQNTPRv----------ARRDEVVEGVPEPREL 120
gi 195032660 129 eASPSSSRPDS-------VMPWFERRLDQ--SQHGNErslYSMSRDWVSNLPLnasastkknsnSNGDSSIPMVMPEHED 199
gi 514688599 194 PSTHQARRGKSkgvkgaHVMTIFERDINL--LAIDKDtslYSACRAWMAVDTTgdkl---rasvKQPQTPAT-------- 260
gi 195122442 114 NNAAQKSHSES------YVMRLFERSLDL--SKYKEKtplYPICRAWMANQPRnp-------nvAVYNTDGTVPIVKRED 178
gi 194756068 102 SSVSQKAPGES------YVMRLFERSLDL--SKYQDGtplYPICRAWMANQPRnp-------svASFHTDASDSSVKRED 166
gi 308465479 112 STSLLDSPRKTmtrdskIMFELRGKPFEMvaGRFEEE---YSLGRAWVKGHMNndy-----vpiNTKRTEFAPNLAVDYL 183
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121954309 135 MPDIVerfnrk-evleiPDMPKPSETel-----ePFRFERHFAEGEDNEPDLdgvegsadrKEILLQHHKA----RWTKM 204
gi 74966827  184 ACREI------------HRMPRPDKSip----elPIVPSRIDEFDATVDPRY---------ETDLKNEYIR----HWKQV 234
gi 121956081 119 NPQMVdqyrng-elkeiRSMPRPDADlvercplpLPSQTRTSKELLDVEPMS---------KATLLAEHKN----RWTQI 184
gi 195057800 179 NAEEIlaqlrsgelkvvKQMPKPRDTdmdpipqrLPQPN--HKDSGNLEGAS---------KDKLLASNMT----HWKQV 243
gi 170044072 121 QVDVLerynrk-eldqiEKMPGPAESele----afVREERFAERGEEMGTGEeev----lgREELLKGHKA----RWSGI 187
gi 195032660 200 DAEKVlaqqrsgelkvlKHMPKARETdmlpipipLPV-----TQNWDLEGAS---------KQQLLADNMK----RWKRV 261
gi 514688599 261 -----------------FSFPAPDTSapi--dygLHVRPELQKAMANVDACLetal-tgdeTEEAISERKQtlqiKWRKM 320
gi 195122442 179 DAEEVlskllsgelkvlKQMPQARKTemspipprLPNPQ-----DEKLKGAS---------KEELLAENIG----HWKRV 240
gi 194756068 167 NGEEIlaklrsgdikvlTSLPQPRSTdlpvipprLEFAKEEKQREKALEGAS---------RSDLLASNVA----RWKKV 233
gi 308465479 184 ACREI------------HRMPRPDENvp----elPVIPTKIDKFDDQVDPRY---------LSDLKTEYIR----HWKEV 234
                        170       180
                 ....*....|....*....|....*
gi 121954309 205 RRSWQGHRQN-YL-RKYQLSYDLLD 227
gi 74966827  235 KKGWCAHQRR-RT-APHARSIALIN 257
gi 121956081 185 RHNWEQHGRI-RN-QRHVASFELLD 207
gi 195057800 244 RCHRLKHAQA-YErARYEIINQIID 267
gi 170044072 188 KRRWVGHRRN-YL-GKYQQSFDLLD 210
gi 195032660 262 RNHWQKHNQE-YEhARYETIDQILK 285
gi 514688599 321 RRTTNERVVGsYA-QRYRDSLRVIa 344
gi 195122442 241 RSHWLKHAQK-YErERYEIIDQIMD 264
gi 194756068 234 RGHWLKHTQK-YEkERFEVIDQIMD 257
gi 308465479 235 KKGWCAHQRD-RN-ARYAKSIQLIE 257
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