Conserved Protein Domain Family
CEP170_C

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pfam15308: CEP170_C 
CEP170 C-terminus
This family includes the C-terminus of centrosomal protein of 170 kDa (CEP170).
Statistics
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PSSM-Id: 317681
View PSSM: pfam15308
Aligned: 21 rows
Threshold Bit Score: 707.642
Threshold Setting Gi: 755745256
Created: 29-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351698481  1086 MVMQMHT------GPSSSSLvppreALGFVRQESFTKEPASSSAAPNKLPHISSHPL----------LQDLTAVRAARMD 1149
gi 528497461   737 SEDKs-------kGSDSERS-----GKPLVRQGSFTIEKPSGNVPIELIPRINRQNG------------GRERSDSVG-- 790
gi 992179610   741 eesrrrrtedkskSSDGERS-----GKPLVRQGSFTIEKPSGNVPIELIPRINRQVG------------GRERSDSAG-- 801
gi 551491409   684 MEEAKRRkk--deEKAREST-----GKPLLRQESFTVEKPSSSVPIELIPRIDAYTG----------------TKTQSRD 740
gi 767980331   265 MVIQLRPgr--spEPDGPAP-------AFLRQESFTKEPASGPPAPGKPPHISSHPL----------LQDLAATRAARMD 325
gi 741967866   842 MVIQLQTtgk-ppELEGPAPaptkeALAFVRQESFTKEPASGPAVPGQLPQIPSHPL----------LQDLATTRAARMD 910
gi 351695181   710 AEEILKSqt--tkGGDKKES-----SKSLVRQGSFTIEKPTPNIPIELIPHINKQTSctppvalapaSRLRERSDSLDTD 782
gi 514739272   868 NEETIKGqspktsGGEKKES-----SKPLVRQGSFTIDKPSTNVPIELIPHINKQSGsvap--sasaNRTRDRSDSMDTD 940
gi 768915914   779 SEETkg-----gaGEGGEKA-----GKPLVRQGSFTIEKPSGSVPAELIPRINRSGS------------GRERSDSAG-- 834
gi 1039357232  692 KDe----------EKAREST-----GKPLLRQESFTVEKPSSSVPIELIPRIDAYTG----------------TKTQSRD 740
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351698481  1150 LhTQDTHLILKETETALAALEARLLSKTADEE----------GEg--GrTPRPPDDSLSGDSDVDTASTVSLLSGKNGPS 1217
gi 528497461   791 --SMDTATLLKDTEAVMAFLEAKLRDEKKLDP----------I----TpPICPPACPLSPESDIDTASTVSQTAADGDRK 854
gi 992179610   802 --SMDTATLLKDTEAVMAFLEAKLRDEKKLDT----------T----TsPTQATGRSLSPESDVDTASAVS----EAERK 861
gi 551491409   741 G-GIDSVSIQKDSEAVAAFLESTVSDQG-------------------DpPSQSIEGSMSPESDVDTTSTVSQ--ADGVRK 798
gi 767980331   326 FhSQDTHLILKETETALAALEARLLSNSVDAE----------CEg--GsTPRPPEDALSGDSDVDTASTVSLRSGKSGPS 393
gi 741967866   911 LhSQDTHLILKETETALAALEARLLSKSFE-E----------PEggvGsAPGPPEDSLSGDSDVDTASTVSLLSGKNGPS 979
gi 351695181   783 S-SMDTTLILKDTEAVMAFLEAKLR-EDKTDE----------GP---DtPSYNRDNSISPESDVDTASTISLVTGETERK 847
gi 514739272   941 S-SLDTTLILKDTEAVMAFLEAKLREENKTDE----------GP---EtPSYNRDNSISPESDVDTASTISLVTGDSERK 1006
gi 768915914   835 --SMDTATLLKDTEAVMAFLEAKLRDENKLDKkssktgvtaqG----SsGFPARTDSISPESDVDTASTASHVAGEAEKK 908
gi 1039357232  741 G-GIDSVSMQKDSEAVAAFLESTVSDQG-------------------DpPSQSIEGSMSPESDVDTTSTVSQ--ADGVRK 798
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351698481  1218 PTT----PQP--AGPQKERLPPPSVAQDPgsAALGSSRERLSEKQHLLTsPADQGRGEPGRHLA----ARRGHRPRGSLD 1287
gi 528497461   855 AVQ----KRRslSSLYREKSNASTASK-----TTTSARERL-ERKTKTKtTE--SRSDSRRSVQt---SSRGRQP--SQD 917
gi 992179610   862 GVQ----KRRslSSLHKEKSNLSSA---G--KSAASARERL-ERKAKTKaPD--GRADVRRTTQt---ISRARQP--SMD 924
gi 551491409   799 VVQ----KRRilAGQQKERTVVCTSNK-----GPTGSREPL-DRRGKNRtSG----------------PQQPSHPSTSLD 852
gi 767980331   394 PTT----PQP--LRAQKEMSPSPPAAQDPggTALVSAREQSSERQHHPLgPTDMGRGEPVRRSA----IRRGHRPRGSLD 463
gi 741967866   980 PTG----SQP--SGLQREKPPSPPAAQDLggVSLSSARERLSEKQRRPLgPVDTGHGEPARRLA----ARRGHGPRGSPD 1049
gi 351695181   848 STQ----KRKsfTSLYKDRCSTSSPSKDVtkSSSAGAREKV-EKKTKSRsTDVGSRTDGRKFVQs---SGRIRQP--SVD 917
gi 514739272  1007 STQ----KRKsfTTLYKDRCSSGSPSKDVlkSSATSAREKM-EKKTKSRsSDGGSRADARKTVQs---SGRMRQP--SVD 1076
gi 768915914   909 ALAsgelKRRslSSMHREKSNMSTASKs--sVTNASARERL-ERKSKTRtVEVTSRTDARRSVQpssaSSRARQP--SLD 983
gi 1039357232  799 VVQ----KRRilAGQQKERTVVCTSNK-----GPTGSREPL-DRRGKNRtSg----------------PQQPSHPSTSLD 852
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351698481  1288 W-AEERGSNLTHLPNTDIVTPNHETP---EatgagRPGTR-RKP-VPpspslAAREEQSHGST------SVQKVQQ---- 1351
gi 528497461   918 LtDDDQTSSL---AISDILSSDQEMY---S-----SRSHT-KGHfTStddllQSKLDTSKSSRsskpskTPQTTTA---- 981
gi 992179610   925 LtDDEQTSSLP---ISDVLSSDQETY---S-----SRSHGgRGPfTStddllLSKLDSSKGTK------HTSKSSRtsqa 987
gi 551491409   853 LtDDDINS-------NSLLSDSLPVStqdS-----RSSNL-RGQtVGa----STK--SSRAKM------TQPSPSS---- 903
gi 767980331   464 WpSEERGPVLAHLPSSDVMASNHETP---EatgagRLGSR-RKP-AApppspAAREEQSRSSA------SSQKGPQ---- 528
gi 741967866  1050 WpAEDRDSSLAHPPSADTVTSDHETP---GatgaaRPGTR-RKPmAPpppttAAREEQGRGSA------GVQKSQQ---- 1115
gi 351695181   918 LtDDDQTSSVPHSAISDIMSSDQETY---S-----CKSHG-RTPlTStdehvHSKLEGGKGTK--------SKTSPaa-- 978
gi 514739272  1077 LtDDDQTSSVPHSAISDILSSDQETY---S-----GKSHG-RVPfASadellHSKME-GKSAK--------SKSTPva-- 1136
gi 768915914   984 LtDDDQTSSFP---ISDILSSDQETY---SgplghSKSDS-RSAlTSt---------------------nASKASRtlqa 1035
gi 1039357232  853 LtDDDINS-------NSLLSDSQPIS---Tqd--sRSSNL-RGQt------------VGASTK--------SSRAKmtqp 899
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351698481  1352 ----ALTRSNSLSTPRPTRASRLRRARLGDTSDTEVTDSDRGAPAHPEPV---GR---PAAEQAKKLSRLDILAMPRK-R 1420
gi 528497461   982 ----ALAKQAGLPQPRPTRASLLRRARLGDTSDTDLADADRVSVASEVST---TSstsKPPSGRKAQSRIDMLAQPRRtR 1054
gi 992179610   988 -sapPVGKQAGLPQPRPTRASLLRRARLGDTSDTDLADADRVSVASEVST---TSstsKPPSGRKAPSRIDMLAQPRRtR 1063
gi 551491409   904 ----APNKASTVPKPRPTRTSLLRRARLGESSDTEPADMDRMSVASEAST---ASstsRTGIARRGMSRIEALAQPRRpR 976
gi 767980331   529 ----ALTRSNSLSTPRPTRASRLRRARLGDASDTEAADGERGSLGNPEPV---GR---PAAEQAKKLSRLDILAMPRK-R 597
gi 741967866  1116 ----ALTRSNSLSTPRATRASRLRRARLGDASDTEAADGERGPPANQEPA---GR---PAAEQAKKLSRLDILAMPRK-R 1184
gi 351695181   979 --sgSSSKSTTLPRPRPTRTSLLRRARLGEASDSELADADKASVASEVSttssTS---KPPTGRRNISRIDLLAQPRRtR 1053
gi 514739272  1137 --lgQSSKSTTLPRPRPTRTSLLRRARLGEASDSELADADKASVASEVSttssTS---KPPSGRRSISRIDLLAQPRRtR 1211
gi 768915914  1036 attsSMNKQTSLPQPRPTRASLLRRARLGDTSDTDLADADRVSVASEVSttssTS---KPPPGRKGLSRLDMLAQPRRtR 1112
gi 1039357232  900 spssAPNKASNVPKPRPTRTSLLRRARLGESSDTEPADMDRMSVASEAStassTS---RTGIARRGMSRIEALAQPRRpR 976
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351698481  1421 AGSFTGPSDSEAA-PART-GFSGRSVELYcanRKP-TVADAHAAARK-AAATATSTgsrQPFSRAR-----PGSARY--- 1488
gi 528497461  1055 LGSFSARSDSEAT-VSRT-TAARLSAETa--lRLGlKSTNQPATENKlTARMRANSvskLTDPKPK-----TTPVNSt-- 1123
gi 992179610  1064 LGSISARSDSEAT-VSRS-TASRVSAETa--lRLG-LRATNPADSKL-NPRMRANSvskLTDTKTKvappvSGSPAEsfy 1137
gi 551491409   977 VGSPSAQSDSEAT-VAKSrGLGGRSAAGDyalRQGlRGSNVTSLS---GPRARANSaskLPDKTKG-----TSSYGHit- 1046
gi 767980331   598 AGSFTGTSDPEAA-PART-SFSGRSVELCcasRKP-TMAEARAVSRK-AANTATTTgprQPFSRAR-----SGSARYt-- 666
gi 741967866  1185 AGSFTGPSDSEAA-PTRA-GFSGRSVELYcpgRKPtTMAEARPTARK-ATNAAAVp--rQPFSRAR-----PGSARYs-- 1252
gi 351695181  1054 LGSLSARSDSEATiSR-S-STSSRTA--EaiiRSGaRLVP----SDKfSPRIRANSisrLSDSKVK-----SMSSAHgs- 1119
gi 514739272  1212 LGSLSARSDSEATiTR-S-TASSRTP--EaiiRSGtRLTS-AGDSSKvSARTRANSisrLSDSKSK-----SLASAHns- 1280
gi 768915914  1113 LGSISARSDSECTvTRTS-TSSSRMSA-EtalRLGlRSST-PT-ENKlTPRMRANSvskLNETKTR-----TTTSGYcs- 1182
gi 1039357232  977 VGSPSAQSDSEATvAKSR-GSSGRSAAGDyvlRHGlRGSNVASLS---GPRARANSaskLPDKTKG-----TSSYGHit- 1046
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351698481  1489 -----------------S--SNTRRRQQGSDYTSTSEEEYGSHHGSPKHA--------RSHTSTATQTPR-AGSASRACS 1540
gi 528497461  1124 ----------------pS--ANNRWRRVPPEYASTSEDEFGSNRNSPKHI--------RLRPGTTLRTSRvLGGPTPVTT 1177
gi 992179610  1138 aemtlpepedgladeepM--ASSRWRRLPPEYASTSEDEFGSNRNSPKHG--------RLRPGTALRTSK-VSATLTATT 1206
gi 551491409  1047 ----------------pA--SGTRWRRVPVEYASTSEDEYGSNRHISKQG--------PTRPFPSTRVAQ-LGGSAPATP 1099
gi 767980331   667 -----------------S---NTRRRQQGSDYTSTSEEEYGSRHGSPKHT--------RSHTSTATQTPR-AGSSSRARS 717
gi 741967866  1253 -----------------S--PNTRRRQQGSDCTSTSEEEYGSHHGSPKHT--------RSHASTATQTPR-AGGSGRARP 1304
gi 351695181  1120 ----------------pS--VNSRWRRFPTDYASTSEDEFGSNRNSPKHT--------RLRTSPALKTTR-L--QSSGSA 1170
gi 514739272  1281 ----------------pS--VSARWRRFPTDYASTSEDEFGSNRNSPKHT--------RLRTSPALKTTR-L---QSTGT 1330
gi 768915914  1183 ----------------pTvsSSSRWRRLPPEYGSTSEEEFGSSRNSPKHGgrsyarphHLVPHRNSRMST-TGGPSSSGV 1245
gi 1039357232 1047 ----------------pA--SGTRWRRVPVEYASTSEDEYGSNRHISKQG--------PTRPFPSTRVAQ-LGGSAPATP 1099
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351698481  1541 RAPGp-----RDTDDDDEepDPYGFIVQTAEIAEIARLSQTLVKDVAILAREINDVAADGDSLGSAGPTRSPSLGNVPST 1615
gi 528497461  1178 TSPGglllknRMREQEEY------IRDWTAHSEEIARISQDLAKDLAILAREIHDVAGEIDSVSSSGTAPSTTVSTAATT 1251
gi 992179610  1207 SPGGiam-khRMREQEEY------IRDWTAHSEEIARISQDLAKDLAILAREIHDVAGEIDSVSSSGTAPSTTVSTAATT 1279
gi 551491409  1100 NPAGltslkqNSRDQDEY------MRDWTAHSEEIARISQDLAKDLAMLAREIHDVAGEIDSVSPAATDPGAL------- 1166
gi 767980331   718 RAPGp-----RDTDDDEEepDPYGFIVQTAEIAEIARLSQTLVKDVAILAQEIHDVAGDGDTLGSSEPAHSASLSNMPST 792
gi 741967866  1305 RAPGl-----RDTDDEGEepDPYGFIVQTAEIAEIARLSQTLVKDVATLAREIHDVAGDGDSPGSPGPARSPSLNNVPST 1379
gi 351695181  1171 MPTSsssfkhRIKEQEDY------IRDWTAHREEIARISQ----DLALIAREINDVAGEIDSVTSSGTAPSTTVSTAATT 1240
gi 514739272  1331 ATQSsntfkhRIKEQEDY------IRDWTAHREEIARISQ----DLALIAREINDVAGEIDSVTSSGTAPSTTVSTAATT 1400
gi 768915914  1246 AAPGgvgvkhRMKEQEEY------IRDWTAHSEEIARISQDLAKDLAILAREIHDVAGEIDSVSSSGTAPSTTVSTAATT 1319
gi 1039357232 1100 NPAGltslkqNSRDQDEY------MRDWTAHSEEIARISQDLAKDLAMLAREIHDVAGEIDSVSPAATDPGALL------ 1167
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351698481  1616 PASTISAREELVQRIPEASLNFQK-------VPPGT--------LTS-QDLDQNMNNSHEDAL-GNKTRPRNREEacspg 1678
gi 528497461  1252 PGSAIDTREELVERVFDESLNFRK-------IPPVVhtka-seiNGRpVELRPHAPDSLDPQA-ALRRRTWNRDE----- 1317
gi 992179610  1280 PGSAIDTREELVDQVFDGGLNFRK-------IPPVVqtka-peiNGRsVELRPRAPDSMDPQA-ALRRRTWNRDE----- 1345
gi 551491409  1167 ----------LEESVFDDGMDLGGstaeqsrIVAGE--------GQT-VELRQRSSND-QSSR-SIRRQTWNRDD----- 1220
gi 767980331   793 PASTISAREELVQRIPEASLNFQK-------VPPGS--------LNS-RDFDQNMNDSCEDAL-ANKTRPRNREE----- 850
gi 741967866  1380 PASTISAREELVQRIPEASLNFQK-------VPPGS--------LGP-RDLDQNMNDRCEDAL-ANKTRPRNREE----- 1437
gi 351695181  1241 PGSAIDTREELVDRVFDESLNFRK-------IPPLVhsktpegnNGRsGDPRPPGAEPPDHLT-ITRRRTWSRDE----- 1307
gi 514739272  1401 PGSAIDTREELVDRVFDESLNFRK-------IPPLVhakp-pegNGRpNDARPQLPDITDPPT-ITRRRTWSRDE----- 1466
gi 768915914  1320 PGSAIDTREELVDRVFDESLNFRK-------IPPVIptnkppeiNGKpPELRPRAPDSLEPR--ALRRRTWNRED----- 1385
gi 1039357232 1168 -----------EESVFDDGLDLGG--------STAEqsri-pagEGRtVELRQRSSN--DQSSrSIRRQTWNRDD----- 1220
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351698481  1679 prmlltmqgV---IFDNLMLNPVSQLSHAIRENTEHLTEKMKVLFQNTGRSWEDLEARINAENEVPILKTSNKEISCILK 1755
gi 528497461  1318 ---------A---VLDSLLLTSVSQLSSKIRQSVDKTAGKIRILFKDKDRNLDDIESKLCLDNEVPLPKTSNKEISSILT 1385
gi 992179610  1346 ---------VrpaVLDTLLLTSVSQLSSKIRHSMDKTVGKIRILFKDKDRNWDDIETKLSSETDVPLLKTTNKEISLILT 1416
gi 551491409  1221 ---------L---YLDNVLLASVTQLSTRIRQSVDKTTYKVRILFKDKERKWDEIETKLQAEHDSLVLKSSNKEISTIIQ 1288
gi 767980331   851 ---------V---IFDNLMLNPVSQLSQAIRENTEHLAEKMKILFQNTGRAWEDLEARINAENEVPILKTSNKEISSILK 918
gi 741967866  1438 ---------V---IFDNLMLNPVSQLSQAIRENTEHLAEKMKILFQNSGRAWEDLEARINAENEVPILKTSNKEISSILK 1505
gi 351695181  1308 ---------V---MGDNLLLSSVFQFSRKIRQSIDKTAGKIRILFKDKDRNWDEIESKLRTESEVPIVKTSSMEISSILQ 1375
gi 514739272  1467 ---------V---MGDSLLLSSVFQFSRKIRQSIDKTAGKIRILFKDQDRNWEEIENKLRAESEVPIVKTSSMEISSILQ 1534
gi 768915914  1386 ---------A---VLDSLLLNSVSQLSSKIRHSVDKTAGKIRILFKDKERNWDEIENKLRSESETPLLKTSNKEISSILF 1453
gi 1039357232 1221 ---------L---YLDNVLLASVTQLSTRIRQSVDKTTCKVRILFKDKERKWDEIETKLQAEHDSLVLKSSNKEISTIIQ 1288
                          810       820
                   ....*....|....*....|....*...
gi 351698481  1756 ELRRVQKQLEVINAIVDPNVNLDLLTGN 1783
gi 528497461  1386 ELKRVEKQLQVINVMVDPDGTLDALTSL 1413
gi 992179610  1417 ELKRVEKQLQVINVMVDPDGTLDALTSL 1444
gi 551491409  1289 DLKSVEKQLSVIDMMVDPDGTLDALSSM 1316
gi 767980331   919 ELRRVQKQLEVINAIVDPSGSLDLLTGN 946
gi 741967866  1506 ELRRVQKQLEVINAIVDPSGNLDLLTGN 1533
gi 351695181  1376 ELKRVEKQLQAINAMIDPDGTLEALNNM 1403
gi 514739272  1535 ELKRVEKQLQAINAMIDPDGTLDALSNL 1562
gi 768915914  1454 ELKRVEKQLQVINVMVDPDGTLDALASl 1481
gi 1039357232 1289 DLKSVEKQLSVIDMMVDPDGTLDALSSM 1316
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