Conserved Protein Domain Family
HEXIM

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pfam15313: HEXIM 
Hexamethylene bis-acetamide-inducible protein
HEXIM is a transcriptional regulator that functions as a general RNA polymerase II transcription inhibitor. In cooperation with 7SK snRNA it sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation. HEXIM may also regulate NF-kappa-B, ESR1, NR3C1 and CIITA-dependent transcriptional activity.
Statistics
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PSSM-Id: 317686
View PSSM: pfam15313
Aligned: 31 rows
Threshold Bit Score: 73.5774
Threshold Setting Gi: 762088625
Created: 29-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17555808   69 MAPPNSTQFLLEDRearadaefeneqkfeaaerrrV---------R---------TMSGSYEHMRP-AY----------- 118
gi 312082329 147 MAPYNTTQFLLEDHek------------------rTmppdvgdslP---------GMTAHQRQSTA-GF----------- 187
gi 340373465 117 VAPFNSTQFLIDDRced---------------qyrR---------P---------SRTLSFDSSSG-VTgamgkwansss 162
gi 541040677 115 MAPYNTTQFLLEDRek------------------rV---------TadsdgdsvnGTGISINGNRAfHS----------- 156
gi 390359597 128 PTPYNTTQFLMEDHkv------------------vT---------P---------DLS---NMGAF-DE----------- 156
gi 196013386 121 VTPFNTTQFIMDDYekarar------------------------------------------------------------ 140
gi 762088625 133 VAPYNTTQFLMEDH------------------------------------------GKADQNIGEG-QL----------- 158
gi 156370848  46 AAPENTTQFLMDDHek------------------fE---------Pfv-----lsSPSLSPNSSGC-EF----------- 81
gi 332030157 128 PALYNTTQFLMADHsdlpdl----------eqklsE---------A---------ASLEVPALFPK-PW----------- 167
gi 357628414  27 QAPFNNNQFLMEIH-----------------------------------------KPEPENNFLLY-RT----------- 53
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17555808  119 ----WcTiepatttadfG----------SD------DNNDLDSTSGE-SEADREMEREFETDYLEVKRERIQSMTRSQLA 177
gi 312082329 188 ----SpThercgtigqsG----------SEmggnttDSASYSGGEDD-E-----MERQFDADYDYVNMERISNMTKDEVA 247
gi 340373465 163 niitP-SpspgasdgtnNkcfffyplslGD------DVHYDLSDEDQ-EA---FLEADFNQVYLQLKLNRLEGMSKQDLI 231
gi 541040677 157 ----P-Qrdrvr-llsgS----------DP------GGNTSESGSVS-GEEGERLEREFDAEYDSVNLMRISGMSREEVT 213
gi 390359597 157 ----Nhdv------nlsS----------SD------EVLE---NENE-E----YLVRNFTAVYDEVQSERLQQMSKEQLV 202
gi 196013386 141 ------------svndnS----------DD------LLDEIQRMEDKsENGNYSGEDEFTAHLEEIRFDKYDRMSKGELV 192
gi 762088625 159 ----Nrnns----restD----------GS------GSTSDSSEEMY-SEEEEFLEKEFAETYDNMHAERLQKMSKDELI 213
gi 156370848  82 ----SsSsvrgspvcerD----------LQ------SVTELVGNFDE-L----YFEKDFNDVYDSIHAETLLGLSKQELI 136
gi 332030157 168 ----ApSrtrdssfsvdS----------DE------DYFYSSPEDEE-E----FLTKEFSTAYEAVHEERLSTLTKTELI 222
gi 357628414  54 ----PsArtrdssfsidS----------ED------NYFHSLPEDEE-E----YLTKEFSSVYEDAQCERLSNMSKNELI 108
                        170
                 ....*....|
gi 17555808  178 AELLERDQDT 187
gi 312082329 248 REYMHLEKIN 257
gi 340373465 232 SQCCNLEDKV 241
gi 541040677 214 REMMCLERNN 223
gi 390359597 203 NEVLELSKKV 212
gi 196013386 193 RYCYQLDKKI 202
gi 762088625 214 KDYIEMETKL 223
gi 156370848 137 YKYMELEKKE 146
gi 332030157 223 QEYRHLEAKM 232
gi 357628414 109 QEYLLLEAKY 118
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