Conserved Protein Domain Family
PRAP

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pfam15314: PRAP 
Proline-rich acidic protein 1, pregnancy-specific uterine
PRAP, or proline-rich acidic protein 1, is a family of eukaryotic proteins. PRAP is abundantly expressed in the epithelial cells of the human liver, kidney, gastrointestinal tract, and cervix. It is significantly down-regulated in hepatocellular carcinoma and right colon adenocarcinoma compared with the respective adjacent normal tissues. In the mouse it is expressed in the epithelial cells of the mouse and rat gastrointestinal tracts, and pregnant mouse uterus. This article describes the isolation, distribution, and functional characterization of the human homolog. PRAP was abundantly expressed in the epithelial cells of the human liver, kidney, gastrointestinal tract, and cervix. PRAP plays an important role in maintaining normal growth suppression.
Statistics
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PSSM-Id: 317687
View PSSM: pfam15314
Aligned: 22 rows
Threshold Bit Score: 43.4873
Threshold Setting Gi: 551523994
Created: 30-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 81872514  100 PELDLDSIYHPMS--E--DVQNEE-VPQS--R--------PILYRQVLHGPEEDLDHISH 144
gi 821450893 145 PEEDRDYFYHPRS--V--EDDIEE-SKML--K---------VSHYAVLQGPEEERDKAFH 188
gi 118092530  75 PEQDHDHLYHPS---V--EVEVEP-EPQS--Rra-----hLVLSAEVENGPSEDRDHIYH 121
gi 992207590 104 PEEDKDQLYHPFE--E--PSNKQP-DSYFqpQ--------QFGQVQLYQEPEQDMDNLYH 150
gi 992207590 179 PEEDKDGLYHESFpsE--SIVVAP-VMQA--F--------DNEPKRVYTEPEEDLDNLYH 225
gi 768916512 138 PEKDEDDVYHGDN--QysEVQTES-EQKI--K--------EDSAVRVYLQPEEDKDDLYH 184
gi 483515855  99 PEEDRDYLYHSAV--E--AEAEEPaDLGK--P--------LVLSMEVQNGPEKDRDHLYH 144
gi 676415388   8 PKEDRDHLHHPQD-----DTREAN-ARVP--F--------WMLSLEVQNGPEEDRDHLYH 51
gi 551523994 169 PEEDLDYLYHKGF----------D-MPVL--QqkvaeapvDIPSQRKYTKPEEDLDGLYH 215
gi 958751810  98 PEPDYDSLYHPPP--E--EAQEEA-GPRS--Q--------VLLSRQVLRGPEEDRDHIYH 142
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