Conserved Protein Domain Family
MDFI

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pfam15316: MDFI 
MyoD family inhibitor
Members of this family inhibits the transactivation activity of the MyoD family of myogenic factors. They affect axin-mediated regulation of the Wnt and JNK signaling pathways, and regulate expression from viral promoters.
Statistics
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PSSM-Id: 317689
View PSSM: pfam15316
Aligned: 10 rows
Threshold Bit Score: 150.831
Threshold Setting Gi: 731454023
Created: 29-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1040696804 139 LPDHIP----TIS----HKIDKGNVKPclp-------ngTSPV-VNGCAVTCSPPASSPQ-------------------- 182
gi 327272974   79 QPQRLPlpnaVPL----EKCKEETGKIqng-------haCPNH-GSGFRNGVKPGIPDGS-------------------- 126
gi 556997199   78 QPHPLP----HPTasalEQTEEETGKLqng-------hvVLTN-GSGIHNGVTHGAADH--------------------- 124
gi 597763927   76 LPDHVP----VLP----HKIEKESPSPlng-------psPPDIvTNGSPPICTPPTASKG-------------------- 120
gi 1003952884  38 lPVLHE----VMLssedHP----ENQLtnekhtdektvkGIVM-SSVAEFSMADTSSKET-------------------- 88
gi 821470153   29 ngvpgktrksmniavgkylpnleNTQLtnekhsdeksvkGIVI-NSVSEFNIADAPSKEA-------------------- 87
gi 731454023   86 QPQGNP----LGCt------------------------pLLPN-GSGHPSELSDARRVGN-------------------- 116
gi 542235192   72 qseskP----VPT----ETAEEDTAKDqngfhhstagtpVLNN-GNGIHPGGSQATRTCScgatistnatggsrpgsgaa 142
gi 326911372   76 QPQRLP----QPNtsalERGEEESGKVqng-------haGLSN-GSGMHNGVKHASADN--------------------- 122
gi 940751399  126 QPQRLP----QLQtsaqEPNEEDIDKTknc-------hkSLSN-GNGIHHGAKHVSVDN--------------------- 172
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1040696804 183 ----------VSTSRPAAQ-------QkcnphakcnghkqPPRKQM--SSTS-------QSqksfnGDATQIQRVAGDDC 236
gi 327272974  127 ----------RRFSAPVSQ-------K-------------MHKKIQ--SSLSvnsgsskKS-----TAYSHKAGSLPEDC 169
gi 556997199  125 ----------KKLPAPVSQ-------K-------------MHRKLQ--SSLsvs--sdsSKrsklsSTNSQKPGSSPEDC 170
gi 597763927  121 ----------LRTPDPAQVpkcnghsH-------------PHKKRL--HSTS-------KSqqslkASATQIQQVAGDDC 168
gi 1003952884  89 --------------------------K-------------NEKKLSeaSRSSiaslekcReft-yiEDDASVHQRDSDDE 128
gi 821470153   88 --------------------------P-------------NEKKLSa-SSTSlsspeecQTkfsylQNDTSFHQRDNDDE 127
gi 731454023  117 ----------GALGGP----------K-------------AHRKLQ--THPSlasqgskKSkgstkSAAPQIPLQAQEDC 161
gi 542235192  143 tatpmteqprKQPSTPVSQ-------R-------------MQRKLR--SSLSvnsdssrRSkg--sSTGSQKP-PLPEDC 197
gi 326911372  123 ----------RKLSSPVSE-------K-------------MHRKIQ--STLSvnsngskKSki--sSAFSQKPSPE--DC 166
gi 940751399  173 ----------RRLSAPVSQ-------K-------------MHRKIQ--SSLSvnsdinkKSkv--nAVFSQKPGSSPeDC 218
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1040696804 237 CAHCILACLFCEVLSWCSAV---AQCLACGLECDAlcccgeaaggglACCAEDs-----CSALLDCGILEDCCQSSDCLE 308
gi 327272974  170 CVHCILACLFCEFITLCSLVleqASCGICPAEACC------------CCCGEEmgddcnCPCDMDCGIMDACCESSDCLE 237
gi 556997199  171 CVHCILACLFCEFLTLCNIVlgqASCGICTSEACCcccg----ddmgDDc--------nCPCDMDCGIMDACCESSDCLE 238
gi 597763927  169 CVHCILACLFCEVLSLCSAV---AQCLACGMECDAacccg--eacsvACCSEDp-----CSALLDCAILEDCCQSSDCLE 238
gi 1003952884 129 CATLILACLFCQFWDFLIMLp-----dTCEHWLIDtccpsn--ryyqtSDEDHsnndcnCDCDIDCSLFESCHETGECLE 201
gi 821470153  128 CASLILTCLFCQFLDCLLMLp-----dTCETVCINtccpsh--ryhhaSDENHarndcnCSCDVDCSLFESCHETSECLE 200
gi 731454023  162 CVHCILSCLFCEFLTLCNIVldcATCGSCSSEDSClc---------ccCCGSGecadcdLPCDLDCGILDACCESADCLE 232
gi 542235192  198 CVHCILACLFCEFLTLCNMVvaqASCGACTSE--Vcc---------ccCCTDDlgddcnCPCDMDCGIMDACCESSDCLE 266
gi 326911372  167 CVHCILACLFCEFLTLCNIVlgqASCGICTSEac------------ccCCGDEmgddcnCPCDMDCGIMDACCESSDCLE 234
gi 940751399  219 CVHCILACLFCEFLTLCNIVlgqASCGICTSEac------------ccCCGDEmgddcnCPCDMDCGIMDACCESSDCLE 286
                         250
                  ....*....|..
gi 1040696804 309 ICLECCSICFPA 320
gi 327272974  238 ICMECCGICFPS 249
gi 556997199  239 ICMECCGICFPS 250
gi 597763927  239 ICLECCSICFPA 250
gi 1003952884 202 LAMEISEVCYr- 212
gi 821470153  201 LAMEISEICYr- 211
gi 731454023  233 ICMECCGLCFSS 244
gi 542235192  267 ICMECCGICFPT 278
gi 326911372  235 ICMECCGICFPS 246
gi 940751399  287 ICMECCGICFPS 298
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