Conserved Protein Domain Family
RHINO

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pfam15319: RHINO 
RAD9, RAD1, HUS1-interacting nuclear orphan protein
RHINO, or RAD9, RAD1, HUS1-interacting nuclear orphan, is a family of eukaryotic proteins. Under genotoxic stresses such as ionizing radiation during the S phase, RHINO plays a role in DNA damage response signalling. It is recruited to sites of DNA damage through interaction with the 9-1-1 cell-cycle checkpoint response complex and TOPBP1 in a ATR-dependent (ataxia telangiectasia and Rad3-related) manner. It is required for the progression of the G1 to S phase transition of breast cancer cells, and it is known to play a role in the stimulation of CHEK1 phosphorylation. It interacts with RAD9A, RAD18, TOPBP1 and UBE2N.
Statistics
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PSSM-Id: 317692
View PSSM: pfam15319
Aligned: 21 rows
Threshold Bit Score: 240.368
Threshold Setting Gi: 1033837606
Created: 29-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119368342    1 MPPRKKRRQ-AAQKPQLLFHQQPLEAPKHRCRF-PQLPvVTHTRQVPSKPVDHNTIT-SWVSPQFDTTAESWFPGKRk-- 75
gi 395538810    1 MPPRKKGKR-QPRKAQLAFREGPLEGPKHPYGS-PQAA-AALPRCAPVKPLDHRTVT-SWVSPQFENT-GGWLPLYQk-- 73
gi 620950572    1 MPPGKKSRR-PIPRAQLLFREAPLEGPKHPYGS-PQPT-DTRPRPVPTKPIDRKTAT-SWVIPQFEGSTGGr-------- 68
gi 573891990    1 MPRKGKNSYtQLKKPPLLFQERPIDGAKHQYGT-PIKS-AVNPLRVVAQPCEQNTTSeQWVTSQFDTTMQLHFPARRrkr 78
gi 514448380    1 MPPKKRR----SNKAQLLFHQQPLEGPKHHCESvRQR--ATHTVQVPSKPTD-QAFA-SWVSPQFDTTVDSLFPARRk-- 70
gi 351696907    1 MPPKKGRGQ-PSHKAQLLFHQQPLEGPKHHCGSvKQRLtRTRTRQGPGKPID-GAIA-SWVSPQFDTTVESFFPGHQk-- 75
gi 113931246    1 MPRKKQTSY-NASKPRLVFLESPKQGLRHEYGL-PPDK-AAHPVCVPTKPLDHNASA-SWVTPQFDQTEELHFPARRrlr 76
gi 1020933002   1 MPPKKKCTH-KARKAELVFLERPRAGPIHCYET-PLRS-AENPRRVPTKPVDRNTSA-VWVCPQFDTTKSVVLKACRk-- 74
gi 224043791    1 MPPKKKCTH-KARKAELIFLEKPRAGAIHCYEA-PLHL-AENPRRVPTKPVDLNTSA-AWVCPQFDATKSVVLKACQk-- 74
gi 326912621    1 MPPKKKRTH-KTRKAELVFLERPWEGPIHCCET-PLYV-AENPVCVSTKPVDQNTSA-TWVCPQFETTKSLVLRVCQk-- 74
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119368342   76 hHH-----RDH--------A--RRSS----RKSTSSRFPCLTFETPQSSa-----------------------SSATPGI 113
gi 395538810   74 qHQvpynlRNL--------A--KGSS----RKAAKHRFPPLSFESSVASs-----------------------SETASDN 116
gi 620950572   69 rPArqrppRDP--------V--GNSG----RKPHPCKFLPLAFAGLQGPc-----------------------REQAPTS 111
gi 573891990   79 qQSgsfthQRS--------Vl-GRSSlvraKKTSVCKFPSLTFECSFEApcqpqqpllavsagkgscqtglpeKNEALEV 149
gi 514448380   71 -HR-----RDR--------A--RLSS----RKST-CKFPHLSFESSKSSs-----------------------RPEIPAI 106
gi 351696907   76 -HH-----QDR--------A--RLSS----RKST-CKFPHLVFENPLFSs-----------------------SPEIPEI 111
gi 113931246   77 hMSsnttlQNR--------SelRGSG----TRPGACKFPSLSFTK----------------------------------- 109
gi 1020933002  75 kHRgphkpYNQnanhssfhA--GG----------ACRFPPLTFENPEGHe-----------------------FPPLDDP 119
gi 224043791   75 kHRgpqkpYNQdanhssfhA--GGAC----QGAVACRFPPLTFENPEGHa-----------------------VPLLDDP 125
gi 326912621   75 kQHgshklQNQdvnygllhA--ETAC----RRSVACKFPPLIFENSEVCs-----------------------VHSTDTL 125
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119368342  114 L-------ASRDGPSQPEKDIS--GRPLVP-------M------LSP----QSCRELSAHTFPDfpc--vfiPPDIQTPE 165
gi 395538810  117 L-------LVMECPMQCPKDTF--RRPLIP-------I------FSP----QSCGELSSHDFQNsdy--mviPPDIQTPE 168
gi 620950572  112 PpavkrpgRASQSPTRARVRAG--RQPLVP-------M------FSP----QSCGHLSGREPASpgf--aflPPDIQTPE 170
gi 573891990  150 NrgfeslnGVQKNPRKLSSDVCevRRTPVP-------EmerdleGTP----RACRDSDMESAST--------PPSLHTPG 210
gi 514448380  107 P-------LVRECLSRSERDVS--RQPLVP-------L------LSP----QSCEEPSAHVLQSslc--vfpAPDIQTPG 158
gi 351696907  112 P-------SVKECRSQSEKDIS--RQPLVP-------M------FSP----QTCGELSAHALQSlpc--vfaAPDIQTPG 163
gi 113931246  110 --------GTVKAPRKRSVCAR--PKPTLPkqrernvL------LSPlpqeDSCSNvl-------------tPPDVRTPE 160
gi 1020933002 120 Nrs---rkNAQCSHNQPKKGTA--ANANFQ-------V------KSP----ENCGEPAP----QpveqevlcPPDAEATQ 173
gi 224043791  126 Ncl---rkNAQCSPIQPRKGTA--ANANIQ-------V------KSP----ENCGELAveqd-------vlsPSDAEAAQ 176
gi 326912621  126 Sha---gkNTQHSHSQFKKGIG--SKANIQ-------V------NGS----ENCSE-TPLSISQpvgpdvfsPLGTGMPQ 182
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119368342  166 SP-----GQ-GEpi--------pSELRENSLPSCSL--HTSTPKSPEP-GPVLVTDTPEEKYGIKVTWRRRRHLFAYLRE 228
gi 395538810  169 QSp----VKdSGhi--------pTDHRQHVKRSCPL--LTDPPKSPDP-GPVLVADTPEEKYGLKVTWRRRHQLLCYLRE 233
gi 620950572  171 MPs----GR-Gp-----------EDPEPSPRPFGGLlsHSSPPEDSGP-GPTLVLDTPEESYGLKVTWRKRRHLLAYLRE 233
gi 573891990  211 ADs----G--GRrs--------cESQNFASDLAGRLifFAPTPTDTESqAETLVKDTPEQDYGVKVTWRKRKGIMRFLQD 276
gi 514448380  159 PS-----ER-EDps--------pPGQGENSPPVCV---YSPTPDTPDP-GPVLVKDTPEEKYGVKVTWRRRRHLLVFLKE 220
gi 351696907  164 PS-----VR-EDss--------pPEQRENSLPVCV---HTCAPHSPEP-GPVLVKDTPEEKYGIKVTWRRRRHLFEYLRE 225
gi 113931246  161 TSl----NC-NTelpngipvgrsPDRGQDKPRD-----GFDSPVMTGP-SHVLAEDTPEHEYGVKNTWRRREQLMTYLKA 229
gi 1020933002 174 VPpprnvGC-SDtp--------pQ-SSHAWHPENELalGTDPCGRGEA-AAVLVTDTPEHEYGVKVTWRRRPHIMKYLRE 242
gi 224043791  177 VPsprngRC-SStl--------sP-SSHAWHPEEELpfGTDPCGRGEA-AAVLVTDTPEHEYGVKVTWRPRPHVMRYLRE 245
gi 326912621  183 LPslrncTC-SSal--------pQISSHA-----ELvsSVLHCGREQL-AGTLVMDTPEREYGIKVTWRRRPHLLKYLRD 247
                         330
                  ....*....|.
gi 119368342  229 RGKLSRSQFLV 239
gi 395538810  234 KGKLNMSQCLV 244
gi 620950572  234 RGRLSQSQFLV 244
gi 573891990  277 QGKLTSKEALV 287
gi 514448380  221 RGKLSRSQFLV 231
gi 351696907  226 RGKLSRSQFLV 236
gi 113931246  230 RGRLKKSQIVV 240
gi 1020933002 243 QGKLSAADILV 253
gi 224043791  246 QGs-------- 248
gi 326912621  248 RGKLSTADILV 258
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