Conserved Protein Domain Family
Ashwin

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pfam15323: Ashwin 
Developmental protein
This family of proteins are found in eukaryotes. These proteins have an important role to play in developmental biology, particularly embryogenesis. It plays an important role in cell survival and axial pattern. It is also thought to be a crucial subunit in the tRNA splicing ligase complex. Proteins in this family are typically between 141 and 232 amino acids in length. There are two conserved sequence motifs: HPE and PQR.
Statistics
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PSSM-Id: 317696
View PSSM: pfam15323
Aligned: 11 rows
Threshold Bit Score: 170.02
Threshold Setting Gi: 156377247
Created: 29-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119361251   21 VDLLLHPELLSQEFIQLMLQERNIAVSD--PE--DRDRLTGLYLQHVIPLPQRELPRSRWGKRMEKSR-----------P 85
gi 973192663   24 TDLLLHPELLSQDFILLTLYEKKIPVEK--EKeaNRDHLTNLYLQHVIPLPQRDLPSSRWGKRMEKIR-----------A 90
gi 327268060   21 dllllhpellSQEFLLLTLEQRNVPVEN--ELkvSKDSLTDLYVQHVIPLPQRELPKTRWGKRMEKQR-----------G 87
gi 556984238   19 SDFLLHPELLSRDFVLLTLQEKKIPIEN--EQvvDKDGLLDLYVQHVIPLPQRELPKSRWGRMMEKRR-----------E 85
gi 301623798   16 SALLLHPELLSRDFLLLSLERRNIPVED--AFn-DKEKLTKIFVQHAMPLPQRDLPRNRWGRMMESKR-----------G 81
gi 597784202   23 TDLLLHPELLSEDFIKLVLNERKICTED--NE--DRDQLTDLYIQHVIPLPQRELPNSRWGKRMEKTK-----------A 87
gi 261289815   14 AVDLIHPEILSKDTLIDILTQRLVLKHHhgDEslDKTHLVEMFYKAVTPKPQRKYRLNRRGRVMTKAQirraklrakttG 93
gi 156377247   19 TVSYDHPEILERETLVDVLCTKGIDRQE--INalDKVDLVKLFYKYAAPLPQRAQQLRRAKRKPPKp------------- 83
gi 395843160   13 SELLLHPELLSQEFLLLTLEQKNIAVEN--DVkiNKDNLTDLYVQHAIPLPQRDLPKNRWGKMMEKKR-----------E 79
gi 620955140    1 --------------------------------------------------------------MMEKKR-----------E 7
gi 1020935851 149 ELLLLHPELLSEEFLRLTLEQKNILVEN--DAkmDKDGLTDLYIQHAIPLPQRDLPKSRWGKMMEKKR-----------Q 215
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119361251   86 RLS----S--SSTHSSSTD----SGRKRPL-------------------IVFDGSS---TST-GcVKLKKPD-------- 124
gi 973192663   91 LQSp--aNrsSQQQGSACD----NSRKRPL-------------------IVFDGSS---TKT-S-IKLKKTE-------- 132
gi 327268060   88 QQVt--kH--DMKSFAAVE----NLRKRPL-------------------IVFDGSS---TST-S-IKVRKTE-------- 127
gi 556984238   86 QQVg--lF--VQTKSLATD----GSRKRPL-------------------IVFDGSS---TST-S-IKLKKNE-------- 125
gi 301623798   82 EKKi---T--TVQKSAGTE----GVRKRPP-------------------IVFDGCS---TST-S-IKVKRTE-------- 120
gi 597784202   88 RQSs--tS--GHGS--STD----SGRKRPL-------------------IVFDGSS---SSTgS-VKLKKPD-------- 126
gi 261289815   94 QQEvqmnM--GLKRSASPT----EPRLKPP-------------------INCVNFQ---RKT---IKLGSSPksaaasse 142
gi 156377247   84 -------S--EHQPSASPKdiviGSRKRALtsegplrsklyrpddfskiIINKGPSkqkNKT-D-IPMQTSK-------- 144
gi 395843160   80 QHEi--kN--ETKRSSTVD----GLRKRPL-------------------IVFDGNS---TSTs--IKVKKTE-------- 119
gi 620955140    8 QKEs--kN--ESKSDVAVG----GLRKRPL-------------------IVFDGSS---TSTs--IKVKKTE-------- 47
gi 1020935851 216 QNDl--kS--ESKSVAAVE----GLRKRPL-------------------IVFDGNS---TSTs--IKVKKTE-------- 255
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119361251  125 -S---------SS----ApvttDRLK----PPVSsVSLTNPIRKLSGASTNCSSSN----------------FSNRTPVS 170
gi 973192663  133 -A---------GS----Ga--vDRLK----PPPS-GNLTNTIRRLSGPSANCSLDDshrss-------anhlSGKEEAQN 184
gi 327268060  128 -N---------GT----V----DGLK------LTaGSASAPCRRLSVSSDSLACASvstdss----dfkigtSINESKQN 179
gi 556984238  126 -N---------GT----A----DRLK----PPPS-GNTTNAIRRLSSLSSNSSSNSiiaspprdttvrkeetKPNRTPVN 182
gi 301623798  121 -N---------GD----Al---QRLN----PSP----------KESTNSTQNSSPAlqlgfttpnkeakgatAANHGQHD 169
gi 597784202  127 -D---------FSssavA----ERLK----PPPStINLTNPIRKLSGsstncs-------------pssstvSSTQTPAS 175
gi 261289815  143 tN---------TA----A----DRLK----PPPAsVKLS----KVSSTTDSSNGSSklkaepvtlitnpgkkSTAIKLVR 197
gi 156377247  145 -NdlspmsqdsSK----V----TKLKrstpEPPKsKPVKLNRRSFTNHPSDGNK-------------------------- 189
gi 395843160  120 -N---------GD----N----DRLK----PPPQaSFTSnafrKLSHSSSSVSPLIlssnlpm---nnktehNNNDTKQN 174
gi 620955140   48 -N---------GA----N----DRLK----PPPStHTTShplrKLSHPS---SPSVspsvlp----tdvkvpTPNGSEQN 98
gi 1020935851 256 -N---------GA----A----DRLK----PPPAg-STTntvrRLSVPSNA-STYIsasslse---daklgiRNNEAQQN 308
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 119361251  171 SSGAIPKSPSNHS---N----------S---SVHSNNATSKLKRTSPSK-GePDTAKDIKSPETKKKIQHIT--WP 227
gi 973192663  185 NVATIHRSPTGNGkapS----------S---TLPTGGTTIKLKRVAPKEgE-SEATGEQKSPEPKKKIQHVT--WP 244
gi 327268060  180 N-IRINNNMASSQkspP----------S---LPVIGTTVVKLKRAAPKE-E-IDASNGLKPSDSKKKIQHVT--WP 237
gi 556984238  183 NNNNSSSTTVHLKslpP----------S---TSSSGTSIVKLKRAAPKG-E-TE-MGDLKPTEAKKKIQHVT--WP 240
gi 301623798  170 SSPVTDTTLI-SPksaK----------L---QQPIIVSAVKLKRTAPKD-E-SDVANDAKPTEAKKKIQHVT--WP 227
gi 597784202  176 ASGAT-KSPTGNGslsS----------S---GHSSNT-NTKLKRGPPND-G-VPGSPELKSPEVKKKIQHVT--WP 232
gi 261289815  198 SPPTSPTSPVANTgvvKvssptsdilqT---SATETTEQVTEKRKSTDE---TEVSSEQDLNKKKFKPSKIT--WP 265
gi 156377247  190 -------------------------------TTHAGTITQQSKHVEVCK-S-DSDSMDEDIVEVKTQFQKVAvkWP 232
gi 395843160  175 HDLMHRKSPLGSV---K----------SpplSPV-GTTPVKLKRAAPKEe--AEAMNNLKPPEAKRKIQHVT--WP 232
gi 620955140   99 HDVGTGRSSLANV---K----------SppsSPVGSPAVVKLKRAAPKEe--VESVNDLKPTEAKRKIQHVT--WP 157
gi 1020935851 309 NISKTDSSVLTGL---K----------VyplSPIAGTTVVKLKRSVPKEe--SDLPSDLKPSEAKKKIQHVT--WP 367
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