Conserved Protein Domain Family
SIT

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pfam15330: SIT 
SHP2-interacting transmembrane adaptor protein, SIT
SIT, or SHP2-interacting transmembrane adaptor protein, is a disulfide-linked dimer that regulates human T Cell activation.
Statistics
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PSSM-Id: 317702
View PSSM: pfam15330
Aligned: 39 rows
Threshold Bit Score: 56.5884
Threshold Setting Gi: 444727871
Created: 29-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84029591    12 WGLLAFLGLALVISLIFNISHYVEKQRRDEI---------YRY-SDDYipRvdEY----YVEdaPI-----YGNLENIIp 72
gi 395518954   15 WGILAIVGLSLIISLVFNVSYWMEKQRQDKI---------YDYqDDYIpeDd-EY----YTEeaPI-----YGNLDNVLs 75
gi 620959205   11 WVSLIVLILALVISLFFNVSHWLDSRRREKVidgyvdedeDEDvDDYVprEe-ES----YTEdp-----piYGNLTQVs- 79
gi 972959566    9 WLGLAMTAIALLISVCLNIVFCLRQRKCEQV-------------PQQIiyPd-YApsyrEEE--QIdenpiYGNINQDFe 72
gi 545192667   12 WAILAFLGLALVVSLIFNISCYVEKQRQGIT---------YRF-SDDYisRedEY----YIEdtPI-----YGNLDNVIp 72
gi 449485954    8 WGALAFLSLALLVSLTLNIVHYIKKKQ-AKM---------HKD-YEESnpSydGY----HTEddPV-----YGNLNQ--- 64
gi 1020936283   8 WGVLAFLSLALLVSLSLNISHCMKKKQA-KM---------HKD-YKENnpSydGY----DTEdyPV-----YGNLNQ--- 64
gi 971374468   47 WGVLAFLSLALIFSLILNISHYMKKKREAKM---------YKD-NEDNtqSydDC----YTGddPV-----YGNLSQ--- 104
gi 483507498   10 WGVLVFLSLALIVSLILNISHYMKKKQETKM---------YKD-YEDNspSydDH----YTEddPV-----YGNLSQ--- 67
gi 847107573    1 ------MCMAFVISLTINIVYFVVKNKKAKN---------VFYySEGAi-GyePQ----YIEsnPI-----YGNLNQPMl 55
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 84029591    73 ----EPLDENCYEQMKGRPQRSASDPQevAAPAQVPAEAQMCYASLDHSVK 119
gi 395518954   76 ----GPAEESCYEQMKARPERVVNEKQe-LCPMQAEADTQMCYAILDHSFK 121
gi 620959205   80 ---aEPVTESCYEQMRARPPRSGNQEQ--EPPVKAQTDIQMCYASLDHSFK 125
gi 972959566   73 ahedYDCEEECYEQMKAPRKQQTGK--------KPAAEPSMCYASLDLTVD 115
gi 545192667   73 ----EPMDENCYEQMKARPERSVNQLRaaPTPAQATNEAQMFYSSLEHSLE 119
gi 449485954   65 ----DILEECCYEQMKSQPQRPVNQLQ-------VESANQMCYASLDHSVK 104
gi 1020936283  65 ----DILEECCYEQMKSQPPRPVNQLQ-------VEPANQMCYASLDHSAK 104
gi 971374468  105 ----DVLEECCYEQMKSQPQRPVNELQ-------VESADQMCYASLDHSTK 144
gi 483507498   68 ----EVLEECCYEQMKSQPQMPVNQLQ-------VEPDHQMCYASLDHSVK 107
gi 847107573   56 ----EHIDDSCYEQMTAPHSSNREGVQ----LIQAEPEEQMCYAALDLSPK 98
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