Conserved Protein Domain Family
HECA

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pfam15353: HECA 
Headcase protein family homolog
HECA was characterized first in Drosophila where it regulates the proliferation and differentiation of cells during adult morphogenesis. In humans, HECA affects cell cycle progression and proliferation in head and neck cancer cells. It by slows down cell division of oral squamous cell carcinoma cells and may thereby act as a tumor-suppressor in head and neck cancers.
Statistics
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PSSM-Id: 317723
View PSSM: pfam15353
Aligned: 15 rows
Threshold Bit Score: 157.921
Threshold Setting Gi: 260810380
Created: 29-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121955121    44 RCCVP--IGDCFKS--Spvd--------ygsINLED---L---RDCVRVICNNDNCTAGQYMHRECFDHWEEGVLNYLKS 105
gi 1005970642   56 KCCVP--TNCNLNQ--P--------------IRMED---L---NDCVKVICNNENCNQGRYMHKSCFEDFQATVLTYLRS 111
gi 260808558    32 wCCVPgsSGCQLGS--P--------------VSLAN---P---EDVVKVVCNHDGCPEGPYMHKQCFEEWEETVLTFLRS 89
gi 762106573    42 ACCSP--TTCLFPD--Et-------------IDTRD---P---GDAVRVYCNNDQCTLGNWMHGDCFIEWEDTVLAYLKS 98
gi 390331625    43 PCCVP--LSCTEGG--P--------------VHTDD---P---DDCQKVVCNNPECTQGQHMHKFCFDVWEDEVLTYLRS 98
gi 347969173    67 RCCLP--LGECLKP--KgaggnnpfselgamINLED---L---RECVRVQCSNESCTAGQYMHRECFDRWEDEALACLKS 136
gi 968059400    66 RCCYP--NGECTKL--Dt------------lIALDDqsrL---GDYVRVVCNNENCNEGQYMHRDCFEQWEAGVLQQLKA 126
gi 395536943    11 PCATP--LICSFGR--P--------------VDL-D---K---DDYQKVVCNNEHCPYSTWMHLQCFYEWESSILVQFNC 65
gi 340371061    67 MCCNP--RGCILGPieTg-------------SATPT---Q---QEVVRMMCSNEKCPFSPYMHSECFDSFEEQILSCLRG 125
gi 328722493    52 DCCVP--TGDCIMR--Sa------------pIRPED---PraaELYARVVCSDGGCPAGRYMHRECFDAWERLVLVYMKN 112
                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 121955121   106 IGRARS-----WSDKQRQQNLWT------------KKGYDLVFKACSCKCGRGHLRKDLDW 149
gi 1005970642  112 TGRARS-----WSEKQRLQNLWT------------KKGYDLAYKACGCKCGKGHLRKDLDW 155
gi 260808558    90 SGRARS-----WSEKQRRQNLWT------------KKGYDLAYRACACKCGKGHLRKDLNW 133
gi 762106573    99 CGRARS-----WSEKQRLQNLWT------------KKGYDLAFKACDCKCSRGHLRKDLNY 142
gi 390331625    99 SGRARS-----WSEKQRRQNLWT------------KKGYDLAWKACSCKCAKGHLRKDLEW 142
gi 347969173   137 TGRARS-----WSDKQRQQYLWT------------KKGYDLVQKVCGCKCGRGSLKKDLDW 180
gi 968059400   127 SARGRS-----WSERQRVQQLWT------------KKGYDLVYKNCSCKCGRGHLRKDLEW 170
gi 395536943    66 IGRARS-----WNEKQCRQNMWT------------KKGYDLAFRFCSCRCGQGHLKKDTDW 109
gi 340371061   126 MSRARN-----WSEKQRKQNLWT------------KKGYDLVFKFCACQCGKGNLRKDLNH 169
gi 328722493   113 AAASYAngnapQSNSRRIKDLWTvnvnnnnvvnlnKKGYEMAFKACGCRCGRGYLKKDSEW 173
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