Conserved Protein Domain Family
Chisel

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pfam15355: Chisel 
Stretch-responsive small skeletal muscle X protein, Chisel
The murine X-linked gene Chisel (Csl/Smpx) is selectively expressed in cardiac and skeletal muscle cells. It localizes to the costameric cytoskeleton of muscle cells through its association with focal adhesion proteins, where it may participate in regulating the dynamics of actin through the Rac1/p38 kinase pathway. Thus it is implicated in the maintenance of muscle integrity and in responses to biomechanical stress.
Statistics
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PSSM-Id: 317724
View PSSM: pfam15355
Aligned: 6 rows
Threshold Bit Score: 112.715
Threshold Setting Gi: 432929830
Created: 28-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82184084   1 MSKQPSSNVKALQANLNIPMGALRPGAGHPVKRREDTVET-EEV-------SPVTPEEKKPLPGAVKLPGPAVNLSELQN 72
gi 733873411  1 MSKQPASHVKAIQANINIPMGAFRPGAGHPHKRKEVTPEEvEESv-----pATEEEKDKKHLPGAIKLPGPAVNLSEIQN 75
gi 432929830  1 -msKPSTNVKALQANLNIPMGALRPGAGLPVKRREETAAQmEEVppeqscpAAPTPEEKKPSPGALKLPGPAVNLSELKN 79
gi 507574243  1 MSKQPVSNVRAIQANINIPMGAFRPGAGQPPRRKECTPET-EEGv-----pPTSD-EEKKPIPGAKKLPGPAVNLSEIQN 73
gi 327268192  1 MSKQPASNVRSIQANINIPMGALLPGAGQPPKRKEFT-EP-DESl-----pPSSEAEKKKTLPGAKKLPGPAVNLSEIQN 73
gi 118403924  1 MSKQPASNIRSIQANINIPMGAFRPGAGQPPRRKEISTEE-EPHvpm--heSEEKNEEKKPIPGAVKLPGPVFNLSEIQN 77
                        90
                ....*....|
gi 82184084  73 VKSELRWVTK 82
gi 733873411 76 IKSELKFVPK 85
gi 432929830 80 VKSELRWVTK 89
gi 507574243 74 IKSELKYVPK 83
gi 327268192 74 VKSELKFVPR 83
gi 118403924 78 VKSELKFVPK 87
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