Conserved Protein Domain Family
NYAP_N

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pfam15439: NYAP_N 
Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter
NYAP_N is an N-terminal family of eukaryotic proteins that are substrates of tyrosine kinase in the brain. When first identified, the family members were referred to as unconventional myosin XVI, or Myr 8. However, proteins have now been identified as being integrally involved in neuronal function and morphogenesis. The family is involved in both the activation of phosphoinositide 3-kinase (PI3K) and the recruitment of the downstream effector WAVE complex to the close vicinity of PI3K; it also appears to regulate the brain size and neurite outgrowth in mice.
Statistics
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PSSM-Id: 317793
View PSSM: pfam15439
Aligned: 32 rows
Threshold Bit Score: 239.974
Threshold Setting Gi: 597762573
Created: 29-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 152112422 1221 PYHkeklevRNMQEEGSKRTdd------------------------ksGPRHFHPSSMSVCAAVDGL-------GQCLVG 1269
gi 528502328   48 TYLqeknqkKRRQEEAIKRIgedvarv---------------tegggyAGKHFRMGFMTMPAPQDRVp------PPCGPG 106
gi 410924347   42 LFLqekndkKRKKEEAIKRtged----------------------iatEGKHLRIGSITMPEPQERMpiplpqaLACGQA 99
gi 765149029   95 TLLqekndkKRKQEEAIRrtge----------------------nvaaEGKHLRMASITMPDPPERLpmshlhaIACGQG 152
gi 528470236   42 INFqekndkKRKQEEAIKRgee-----------------------vvtEGKHLRMGSMSMPAPAEHMsph-qhqHPCNPG 97
gi 941814153   50 TYLqekhqkKRRQEEAIKRIgedvat----------------asdgaySGKHFRMGFMTMPAPQDRVp------TPT-PG 106
gi 395533658    4 LYRktklewRQHKEEEAKRStskevgpagpsg----pgpgvrardvssLRRSLRMGFMTMPASQEHVp------HPCRSA 73
gi 734645413   44 LYRksrldwRQRDQEGSkksssqndpsa----------tvgkvrdlasFRRHFRMGFMTMPASQDLSp------HSCASA 107
gi 768939926   66 LYRksrldwRQRDQDGSKKSssqndpsat----------vgkvrdlasFRRHFRMGFMTMPASQDLSp------HSCASA 129
gi 564378773    4 LYRktklewRQHKEEEAKRSsskeaaptgpvgsgavpgpgvrvrdiasLRRSLRMGFMTMPASQEHTp------HPCRSA 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 152112422 1270 PSIWSPSLHSV-------FSMDd---sSSLP-----------SPRKQ-----PPPKPKRDPNTRLSASYEavsa----cl 1319
gi 528502328  107 FTVRSQSLHSV-------GGGEe----eGSP-----------TSRKQ-----PPPKPRRDPNTKLSTSSEtvna---gls 156
gi 410924347  100 FSVRSQSLHSVggggnsgGGGDe---eVGSP-----------TSRKQ-----PPPKPRRDPATKLSMSSEavdhspmstc 160
gi 765149029  153 FSVRSQSLHSVggg-nngGGGEe---eVGSP-----------TSRKQ-----PPPKPRRDPATKLSMSSDavdhspiytc 212
gi 528470236   98 FSVRSQSLHSV-------GGLEe----eGSP-----------TSRKQ-----PPPKPRRDPSTKLSISSEavdis-ptyc 149
gi 941814153  107 FTVRSQSLHSV-------GGGEe-----dSN-----------HSRKQ-----PPPKPKRDPTTKLSSSSEavdgv-sgfi 157
gi 395533658   74 MAPRSLSCHSV-------GSMEs---sGSTTggggssgvggdVGARR-----PPVKPRRHPSTKLSMAAS---------- 128
gi 734645413  108 MAPRSQSCHAV-------GAGDtslenGDYS-----------DTQSQhggrcPPAKPKRHPSTRLSSSSAdg-------- 161
gi 768939926  130 MAPRSQSCHAV-------GAGDpdlenGDYS-----------DTQSQhggrcPPAKPKRHPSTRLSSSSAeg-------- 183
gi 564378773   78 MAPRSLSCHSV-------GSMDs---vGGGPggggg-glledSSTRR-----PPAKPRRHPSTKLSMAGP---------- 131
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 152112422 1320 sAa-rEAA--------NE-----AL----------ARPRPHSDDYStmKKIPPRKPKRSPNTKLSGSYEEISGS------ 1369
gi 528502328  157 tGksaKDSe------kFD------A----------SKSRPCSEEY---RRMPPPKPKRNPNTQLSTSFDEsy-------- 203
gi 410924347  161 rG---DRCd-----------------------------AQGCSEDC--RRVPPPKPKRNPNTQLSVSFDEsy-------- 198
gi 765149029  213 yG---EKCd----------------------------aAQGCSEDC--RRVPPPKPKRNPNTQLSVSFDEsy-------- 251
gi 528470236  150 kGdesERCd------gTQ----------------------GCSEDC--RKVPPPKPKRNPNTQLSTSFDEsy-------- 191
gi 941814153  158 kReyqEAKd------gAE-----LS----------EARYHHHSEES--RKMPPPKPKRDPNTQLSSSFDEsy-------- 206
gi 395533658  129 -Ga--ELPps-----kKA-----GS----------QKPGPEGRESS--RKIPPQKPKRSPNTQLSVSFDESCSMaptsrv 183
gi 734645413  162 rGl-pETPppasthsqSKhsdkkNA----------MKKSDSGEIGA--KKVPPLKPKRSPSTQL--SFDPLPPRvphs-- 224
gi 768939926  184 rGl-tEIPpl-----pSG-----YSqskhsekknaMKKSESGEIGS--KKVPPLKPKRSPSTQL--SFDPPATRvpps-- 246
gi 564378773  132 -Ga--ETPps-----rKA-----GS----------QKPTPECRESS--RKVPPQKPRRSPNTQLSVSFDESCAPapsprg 186
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 152112422 1370 -RPGdarpagapgaaarvltpgtPQCALPPAAPP----GDEDDSEPVYIEMLG-HAAR---------------------- 1421
gi 528502328  204 iQHHsskgks-------aslprvSKKKSASQNQSpa-pDTDDEVEPVYIEMVG-NILRdfsri----------------- 257
gi 410924347  199 iKSHgsgaicpskhl-hrvvspselnASPQSDESpt-dDCE--DEPVYIEMGGiDVGSrep------------------- 255
gi 765149029  252 iKSHgnsgvcmskplnyttspceRNHLHSQSDESps-nDCD--DEPVYIEMGGiDVGSrea------------------- 309
gi 528470236  192 iRSNgskg--------------sttmLFSRDGQTps-pQPQDLDEPVYIEMSG-NVGQeat------------------- 236
gi 941814153  207 vRNHcskk------------ssfQGDKSSSQSHSpasrDTDDE-EPVYIEMVG-NILRelk------------------- 253
gi 395533658  184 gALP-------------------LQRHSRGGRGVgehdLSSQDEEPVYIEMVG-DVFQggggssgrssggpagasvgggg 243
gi 734645413  225 --------------------atsLPFQATDSQIQ----TEDGEDEPVYIEMVG-QVFTrdsqtatph-----------pv 268
gi 768939926  247 --------------------aasLPFQAADSQIQ----TGDSEDEPVYIEMVG-QVFTresqtatph-----------pv 290
gi 564378773  187 gNLP-------------------LQRLSRASRIAgdldAGAQEEEPVYIEMVG-DVFRgggrsgggltgpp----lgsgg 242
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 152112422 1422 -------PDSPDPGESVYEEMKCCLPDDg-GPGAGSFLLHgASPP------LLHRAP-----EDEaa---------gPPG 1473
gi 528502328  258 --agangDEEDDQGESVYEEMKYPAYDD-----------L-PSSL------DHGQSRweqcpTPGvpevel-trpttPRG 316
gi 410924347  256 -----lkSEDEEPGESVYEEMKYPALDD-----------------------MEy--------RTDpvgcrs-acptpAPY 298
gi 765149029  310 -----lkSEDEEPGESVYEEMKYPVLDD-----------------------MEy--------RTDpvgcrs-acptpAPY 352
gi 528470236  237 -----prTEEDEPGEAVYEEMKYPALDE-----------------------YDs--------RWDlvncrs-lcvtpCPS 279
gi 941814153  254 ----gqeAVDDEQSESVYEEMKYPMLED-----------------------FLQDVQs-------------------TII 287
gi 395533658  244 tgpptgpDSDSEESEAIYEEMKYPLPEDvaEGRANGAPPTaAVSPl-------hHTHshhshRRPasalqsrqngasTKI 316
gi 734645413  269 tpvattpDSDSDQSEAIYEEMKYPLQEDreSQRHLPTKHEkLRNSkhf-hvLSASPHtprapTPYllqgnkseaesnT-- 345
gi 768939926  291 tpvattpDSDSDQSEAIYEEMKYPMQEDr-------------------------dPHtprapTPYllqgnksesesnT-- 343
gi 564378773  243 ptppaaaDSDSEDSEAIYEEMKYPLPEEtgDGRANGPPPLmAPSPpqqphvLQPHPHp---hRRPasalpsrrdgtpTKT 319
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 152112422 1474 D-----------------ACDIPPPFPNLLPHRPPLLVFPPTpvtcspaSDESPLTPLEVKK------------------ 1518
gi 528502328  317 S-----------------LCDIPAPFPNLLSHRPPLLVFPPApaqcspnSDESPLTPLDVTK------------------ 361
gi 410924347  299 Dpeplsrc---stprnipLCDIPAPFPNLLTHRPPLLVFPPApaqcspnSDESPLTPLDVTK------------------ 357
gi 765149029  353 Dpeplsrc---stprnipLCDIPAPFPNLLTHRPPLLVFPPApaqcspnSDESPLTPLDVNK------------------ 411
gi 528470236  280 EseiytplsrcttprgvpLCDIPAPFPNLLSHRPPLLVFPPApaqcspnSDESPLTPLDVAK------------------ 341
gi 941814153  288 Dseaws--------srgsFCDIPPPFPNLLTHRPPLLVFPSApvqcspnSDESPLTPLDVTR------------------ 341
gi 395533658  317 S-----------------PCEIPPPFPNLLQHRPPLLAFPQA-------KPTTRTPGDGVSR------------------ 354
gi 734645413  346 --------------------KIPAPFPNLLQHRPPLLAFPQP---------AAASSGVGVQNksasakmgtqtssattqa 396
gi 768939926  344 --------------------KIPAPFPNLLQHRPPLLAFPQP---------AAASSGVGVQN------------------ 376
gi 564378773  320 T-----------------PCEIPPPFPNLLQHRPPLLAFPQA-------KSASRAPGDGVSR------------------ 357
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 152112422 1519 --------LPVLetnlKYPVQPeGSSPLSP----------QYSKS------------------------QKGDGDRPASP 1556
gi 528502328  362 --------LPMFdn-vGIVKPGaSPTGTEPqpeaqqqvsgKHHHH------------------------HHHHHHKKSAE 408
gi 410924347  358 --------LPMLen-qSYSKSP--TSSAEP----------PPSAH------------------------LR--------R 384
gi 765149029  412 --------LPMLdn-qSLSKSP--TSSNEP----------TSSAH------------------------IR--------R 438
gi 528470236  342 --------LPMFen-gSFGKSP-TSSSLEPsg-------sASTSH------------------------MR-----RAER 375
gi 941814153  342 --------LPMLen-vSLSK---SGGAEHP----------QGSGH------------------------HRKDRDRDRDR 375
gi 395533658  355 --------LPVL----CHTKES-AVPVPAL----------QVPGR------------------------DQETT--PTPP 385
gi 734645413  397 stssssssNVPAsl--sSKESS---EGGAT----------KQDKH------------------------SRESQLGPA-- 435
gi 768939926  377 --------KASTsskmGTQTSS-VTTQASA----------SSSTSsssnatasgskessggsatqqdkhSRDSQLCPA-- 435
gi 564378773  358 --------LPVL----CHSKES-AGSTPAP----------QVPAR------------------------ERETPPLPPPP 390
                         570       580       590       600
                  ....*....|....*....|....*....|....*....|.
gi 152112422 1557 -GLALFN--GSGRASPPSTPPPpp---------ppPGPPPA 1585
gi 528502328  409 -TKEQQT--ITASGRS-SAPPLtsalyk-sggssaAHGYPR 444
gi 410924347  385 eLTATPT--LTVSGRS-SAPPLpctl-----ykssSSSYQR 417
gi 765149029  439 eLTSTPT--LTVSGRS-SAPPLpctly----ksssSSSYQR 472
gi 528470236  376 eLTATPT--ITASGRS-SAPPLpcaly---kssssSYSYQR 410
gi 941814153  376 dASHTHT--ITSSGRS-SAPPLassfykssssahsVHGYPR 413
gi 395533658  386 pAANLLLlgPSGRARSHSTPLPpqgsgq--prgekEREIPN 424
gi 734645413  436 ---------PGLRARSHSTPLPpss----------kstSPF 457
gi 768939926  436 ---------PGLRARSHSTPLPpsskstspfshhhhhphhr 467
gi 564378773  391 pAANLLLlgPSGRARSHSTPLPpqgsg----qtrgERELPN 427
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