Conserved Protein Domain Family
NYAP_C

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pfam15452: NYAP_C 
Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter
NYAP_C is a C-terminal family of eukaryotic proteins that are substrates of tyrosine kinase in the brain. When first identified, the family members were referred to as unconventional myosin XVI, or Myr 8. However, proteins have now been identified as being integrally involved in neuronal function and morphogenesis. The family is involved in both the activation of phosphoinositide 3-kinase (PI3K) and the recruitment of the downstream effector WAVE complex to the close vicinity of PI3K; it also appears to regulate the brain size and neurite outgrowth in mice.
Statistics
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PSSM-Id: 317805
View PSSM: pfam15452
Aligned: 8 rows
Threshold Bit Score: 303.414
Threshold Setting Gi: 597762573
Created: 3-Aug-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961880119  610 SQTPSLQQPSSLTGVGEG-VSKSNSGSSSQS----KVGF------MPWDSSASLAADD-GSYWPMQRK-LSFSHGSREAE 676
gi 512955842  573 NKGCGVGAPSPMVKIQLQeQGTDGGAFASIScahvIASAg-----TPEEEEEEMGATTfGAGWALQRKvLYGGRKAKELD 647
gi 612047981  376 RSSPSV--PHSTARNTLQe-GGKMVNASVNTygssQSGSrsrtptSPLEELTSLf----TSGRSLLRK-SSSGRRSKEPA 447
gi 803305963  398 RSSPSV--PHSTPR-PVSd-GSKMVNAAVNTygsaPSGSrsrtptSPLEELTSLf----TSGRSLLRK-SSSGRRSKEPA 468
gi 973186866  461 RSSSSV--PHSLIKNTSQe-GAKLANSSSSThgsmQNVSrsrtptSPLDELTSLf----TSGRSLLRK-SSSGRKSKEPA 532
gi 597762573  691 PQLPILQHSEG---------GAKGGTSTTQAhqqaKAGF------LPWDSSSSLGIDE-QAYWPMHRK-LSFSHSSRDTE 753
gi 768939926  637 SQTPSLHQPSSLTGVGELs-KSNGG--SLQSa---KVGF------IPWDSSASLTTDE-GSYWPMQRK-SSFSHGSRETE 702
gi 657586017  739 SQTPSLQQPSSLTGIGEGaSKSNGGSVSLHS----KVGF------MPWDSSASLAADE-GSYWPMQRK-LSFSHGSRETE 806
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961880119  677 ---KDEGRAWNGSADALLRMDKEDL---Glg-srGGQSGIPVHFSGATSra--lgHCeslagvdsspgfRALPRGGLPLP 747
gi 512955842  648 k-vEDGARAWNGSSEGPGKMEREDR---G-----PVASAIPVRSQGAEGllarihHD------------RGGSRTALPIP 706
gi 612047981  448 ekpTDELKIRSHSTEPLPKLENKERghhG-----ASSSREPIKAQEWDGtpgp---------------pvaSSRLGRSSV 507
gi 803305963  469 eksTEELKVRSHSTEPIPKLDSKERghhG-----ASSSREPIKAQEWDGtpgp---------------pvvTSRLGRCSV 528
gi 973186866  533 e---SEAKSRSHSTEPLPRHESKERgghQ-----PPPKEQP-KAHEWDGvsgq-------------saaAQSNRLGRTSV 590
gi 597762573  754 k--ED-ARVWNGSTDALLRRDRDDV---GvgvrgGGHSGIPVRASGRi------gHSeslagadgppgfRALPRAGLPLP 821
gi 768939926  703 ---KDEGRAWNGSADALLRMDKEEF---Glg-srAGHSGIPVHFSGATSr----tHSdslagvdssagfRALPRVGLPLP 771
gi 657586017  807 ---KDEGRAWNGSADALLRMDKEDL---Gmg-srGGHSGIPVHFSGATSra--lgHSeslagvdsspgfRALPRVGLPLP 877
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961880119  748 CQTFPAC-RNG---EVGRLGRSSSAAGVR--------------------QVGgGDVHRQ-------SS------------ 784
gi 512955842  707 CQTFPAChRNGdftGGYRLGRSASTSGVR--------------------QAA-LHTPRP-------CS------------ 746
gi 612047981  508 SPTLLAGnSSSepkVSCRLGRSASTSGV----------------------------PPP-------SV------------ 540
gi 803305963  529 SPTLLAGnHSSepkVSCKLGRSASTSGV----------------------------PPP-------SV------------ 561
gi 973186866  591 SPTLMLGsGVSeskAVCKLGRSASTSGV----------------------------PPA-------SV------------ 623
gi 597762573  822 CQTFPAC-RNGe---lGRLGRSSSTSGVR--------------------QAG-GDVQRQ-------SS------------ 857
gi 768939926  772 CQTFPAC-RNG---EVGRLGRSSSAAGMR--------------------HVGtGDVQRQ-------SS------------ 808
gi 657586017  878 CQTFPAC-RNG---EVGRLGRSSSAAGVRqvgggdvqrqsslparealnQLH-GLGQPQapcspsgPSvsrqqqqlqlhq 952
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961880119  785 -----------------------LPvRE------A--LN---------QL------------------------------ 794
gi 512955842  747 -----------------------QP-RD------A--LS---------QT------------------------------ 755
gi 612047981  541 -----------------------TPlRQ------AsdLQ---------QS------------------------------ 552
gi 803305963  562 -----------------------TPlRQ------AsdLH---------QS------------------------------ 573
gi 973186866  624 -----------------------NPlRQ------GgeVQ---------QS------------------------------ 635
gi 597762573  858 -----------------------LPaREalsqlqA--LS---------QApcspsltrpqmqaqqqaqfqlqqlhqhhlq 903
gi 768939926  809 -----------------------LPaRE------A--LNqfqqlaqlaQG------------------------------ 827
gi 657586017  953 qqlqlkqqlqqlqqqhhlqlqfqQLaQL------A--QG---------QP------------------------------ 985
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961880119  795 -------------HGva-pAQAPcspsgpgvsrqqqqlqlhqqqlqlkqqlqqlqqqhhlqlqfqqlaqlaqgqppAGGG 860
gi 512955842  756 -------------HPal-pLPLP-----------------------------------------------------LPPP 768
gi 612047981  553 ----------------------Q-----------------------------------------------------VACM 557
gi 803305963  574 ----------------------Q-----------------------------------------------------VACM 578
gi 973186866  636 ----------------------Q-----------------------------------------------------VTQM 640
gi 597762573  904 lqfqqlaqlaaqaQPpa-sGGGG-----------------------------------------------------PGSG 929
gi 768939926  828 -------------QPavsgGGIQ-----------------------------------------------------STTQ 841
gi 657586017  986 -------------PV----SGGT-----------------------------------------------------TPST 995
                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 961880119  861 TMSstsqtQRDGKLLEVIERKRCLCKEIKAHRRPDKSLCKQDSMPILPSWRRTPEPRKTGTPPCQRPQAVVWDTAI 936
gi 512955842  769 PAR-----ERDGKLLEVIERKRCVCKEIKARHRPDRGLCKQESMPILPSWRRGPEPRKSGTPPCRRQHTVLWDTAI 839
gi 612047981  558 QWL-----HGDHTMLEMIEKKRCLCKEIKARQKTEKGLCKQDSMPILPSWKKNTGTKKYSPPPYSKQQTVFWDTAI 628
gi 803305963  579 QWF-----HGDHTMLEMIEKKRCLCKEIKARQKTEKGLCKQDSMPILPSWKKNAGAKKYSPPPYSKQQTVFWDTAI 649
gi 973186866  641 QWV-----YGDNTMMDMIEKKRCLCKEIKARQKTDKGLCKQDSMPILPSWRKNNGTKKDSPPPYSTQTTVFWDTAI 711
gi 597762573  930 GPV-----QRDGKLLEVIERKRCLCKEIKAHRRPDKSLCKQDSMPILPSWRKTPEPRKTGTPPCQRPQAVVWDTAI 1000
gi 768939926  842 --T-----QRDGKLLEVIERKRCLCKEIKAHRRPDKSLCKQDSMPILPSWRRTPEPRKTGTPPCQRPQAVVWDTAI 910
gi 657586017  996 TQT-----QRDGKLLEVIERKRCLCKEIKAHRRPDKSLCKQDSMPILPSWRRTPEPRKTGTPPCQRPQAVVWDTAI 1066
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