Conserved Protein Domain Family
Barttin

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pfam15462: Barttin 
Bartter syndrome, infantile, with sensorineural deafness (Barttin)
Barttin is a family of mammalian proteins that are chloride ion channel beta-subunits crucial for renal Cl-re-absorption and inner ear K+ secretion. Bartter syndrome is a term covering a heterogeneous group of autosomal recessive salt-losing nephropathies that are caused by disturbed transepithelial sodium chloride re-absorption in the distal nephron. Mutations in the BCD proteins lead to sensorial deafness.
Statistics
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PSSM-Id: 317814
View PSSM: pfam15462
Aligned: 17 rows
Threshold Bit Score: 278.956
Threshold Setting Gi: 395530567
Created: 29-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54035724   27 SHDRPQVYGTFYAMGSVMVIGGIIWSMCQCYPKITFVPADSDFQGILSPKA-MGLLENGLaAEMKspSP--QPPYVRLWE 103
gi 637293813  27 SVEKPQIYITFCTLGVLTILIGVVWSMCQCYPKVQIVSAYSESEKFLIKKPgVLCMKNEI-PEKS--SS--QTPYTSLKE 101
gi 395530567  27 taDRPQVYITFCVMGGIMLVSGVIWSMCQCYPKIAFVPADTDFESFLSPKA-RGAGESGLsLSPL--SPrsQPPYSRLEE 103
gi 348556586  27 SHDRPQVYGTFYAMGSVMVIGGVIWSLCQCYPKVTFVPADSDFQGILSPKA---LLENGLtAETK--SP--QIPYTRLWE 99
gi 513016748  27 SHDRPQVYGTFYAMGSVMVVGGVIWSMCQCYPKVTFVPADSDFQGILSAKA---LLENGLaAEMK--SP--QPPYTRLWE 99
gi 532080651  27 SHDRPQVYGTFYAMGSVMVMGGVIWSMCQCYPKIAFVPADSDFQGILSPKP-LGLLENGLaPEVK--SP--QAPYVRLWE 101
gi 354466680  27 SHDQPQVYGTFYAMGSIMVIGGVIWSMCQCYPKITFVPADTDFQGILSPKA-LSLLESSLs-EVK--SP--QPPYVRLWE 100
gi 545498696  27 SHDRPQVYGTFYAMGCVMVIGGVVWSMCQCYPKITFIPADSDFQGILSPKA-LGFLENGLaAEMK--SP--EPPYVRLWE 101
gi 927150911  27 SHDRPQVYGTFYAMGGIMVIGGVIWSMCQCYPKIAFIPADSDFQGILSPKA-LGLLENGLaAEMK--SP--QPPYARLWE 101
gi 126722585  27 SHDRPQVYGTFYAMGGVMVIGGVVWSMCQCYPKITFVPADSDFQGIMSPKA-LGLLDNGLaVEMK--SP--QAPYVRLWE 101
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54035724  104 EAAYDQSLPDFSHIQMKVMSYSEDHRSLLAPem--gQPKLGTSDGgegg-pgdVQAWMEAAVVIHKGSDESEGERRLTQS 180
gi 637293813 102 SEAYEKSLPSYEQVQKTVAGSEEHLGVLPVP-----VPQIRTGAG--------VQPLVQAKAEVHRNSENDRGTYKYPES 168
gi 395530567 104 EEASMQSPPDYHHIQMKVFGSGEDQGVLSAP-----QPEFQAGREgrg---pySEAFVETAV-VHAVEAESHQGRPEARN 174
gi 348556586 100 EAAYDQSLPDFSHIHGKATGYHGDSHPLLAP-----KLEPRTGDGgtgg-pgeAQAWVEAAVVVHRGLDESEGKRTRTQS 173
gi 513016748 100 EAAYDQSLPDFSHIQMKALGYSEDSRMLLAS-----EPGPRPRDTgegg-pcdAQAWVEAAVVVHRGVDQSEGERTRTQS 173
gi 532080651 102 EAAYDQSLPDFSHIQMKVLGHSEDPRPLLAP-----ETQPRTSDGeagg-pqdAQAWVEAAVVVHRGLDENEEERHRTQN 175
gi 354466680 101 EAAYDQSLPDFTHIQMKVLGYSEDPRPLLAP-----EPKTGVSSGgege-phtAQAWMEAAVVVHRGLDEKEGERPGTQS 174
gi 545498696 102 EAAYDQSLPDFSHIQMKVMGYHEDPRPLLASgpgqpQPQPGAGDGgegg-prdAQAWMEATVVIHRGSDEDEGGSQPTPS 180
gi 927150911 102 EAAYDQSLPDFSHIPMKVMGYSEDPRPLLASep--gQLQLGASDGgegg-prdPQTWLEAAVVIHRGSDQDEGERRPSQG 178
gi 126722585 102 EAAYDQSLPDFSRIQMKVMSYSEDPRPLLASep--aQLKPASSDDrgglgprdAQSWVEAAVVVHRGSDEKEGGRTPSQS 179
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54035724  181 --------WPG------PLACPQG------------------PAPLASFQDDLDMDSSEGSSPNASPH-DREEACSPQQE 227
gi 637293813 169 --------QKGatklhsQSKMSKS------------------QAPLASLQEEMDASSMESASNSPFLQrWKSAPNTVFPT 222
gi 395530567 175 lgsleslgGPG------PPCAPYGygaggfgaggfgagsqvpAAPLASFQDDLD-SSCGGSS--------RDPSPPEEEE 239
gi 348556586 174 --------GRS------LPGYPQG------------------PAPLASFQDDLDMGLSEGSSPNPSLP-DGEAPRSPQQE 220
gi 513016748 174 --------SPS------LTGYHQG------------------PAPLASFQDDLDMGSSEGSSPAPSPP-GRAAPWPPQQE 220
gi 532080651 176 ----------S------SPACPQG------------------PAPLASFQDDLDLGSSEGSSPNPSPP-AGKEPHPLAQK 220
gi 354466680 175 --------SP--------PACSQG------------------SAPLASFQDDLDMGSSEGSSPHPSPP-NREEPHP--QV 217
gi 545498696 181 --------RPG------LQACPQG------------------PAPLASFRDDLDMDSSEGGSPNPSPP-EGEGPHPPPRE 227
gi 927150911 179 --------RPS------PQTCPQG------------------PAPLASFQDDLDVGSSEGSSPNLSPPqEVELPLPPP-E 225
gi 126722585 180 --------RPG------PPACPQG------------------PAPLASFQDDLEVGSSEGSSPRPSPA-NGEEPPPPPGE 226
                        250       260
                 ....*....|....*....|....*..
gi 54035724  228 PQGCR--CPLDRFQDFALIDA-PTLED 251
gi 637293813 223 ENQLR--YQLPCYEDFALIDS-VTTEG 246
gi 395530567 240 PWARRtdAQPDCYPDLALIDA-AGADE 265
gi 348556586 221 PRARR--GPLDNFCDAALIDDaPTLED 245
gi 513016748 221 PRASR--SPLDDSHDFALIDD-PSTpe 244
gi 532080651 221 HQACR--GTRDHFYDFALIDD-ASvse 244
gi 354466680 218 PWASM--GPLDRFSDFALIDDtPTSED 242
gi 545498696 228 PWACR--CQLDRFHDFALIDA-PTPED 251
gi 927150911 226 PWACR--CQLDRFHDFALIDA-PTSED 249
gi 126722585 227 PWACR--SPPDRFHDFALIDEvPTSED 251
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