Conserved Protein Domain Family
Ntox21

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pfam15526: Ntox21 
Novel toxin 21
Bacterial genomes and plasmids encode a variety of peptide and protein toxins that mediate inter-bacterial competition. Bacteriocins are diffusible proteins that parasitize cell-envelope proteins to enter and kill bacteria. Contact-dependent growth inhibition (CDI) is one mechanism of inter-bacterial competition. Novel Toxin 21 (alternatively 16S rRNA endonuclease CdiA) belongs to a family of prokaryotic polymorphic toxin systems implicated in intra-specific conflicts. This RNase toxin found in bacterial polymorphic toxin systems, is proposed to adopt the BECR (Barnase-EndoU-ColicinE5/D-RelE) fold, with two conserved lysine residues and [DS]xDxxxH, RxG[ST] and RxxD motifs. In bacterial polymorphic toxin systems, the toxin is usually exported by the type 2, type 4, type 5 or type 7 secretion systems. This is also referred to as the E. cloacae CdiAC. The CdiAC proteins carry a variety of sequence-diverse C-terminal domains, which represent a collection of distinct toxins. Many CdiA-CT toxins have nuclease activities. In accord with the structural homology, CdiA-CT cleaves 16S rRNA at the same site as colicin E3 and this nuclease activity is responsible for growth inhibition.
Statistics
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PSSM-Id: 317870
View PSSM: pfam15526
Aligned: 9 rows
Threshold Bit Score: 94.8801
Threshold Setting Gi: 916826665
Created: 12-Apr-2017
Updated: 23-May-2017
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75432401   157 AAAKKLGY-----RKIKERTRNDAAIFKKGKS-------YISRDVDSHN-GGAWKEAS--SPKNLNRKETRNGTFDKNLN 221
gi 635331719   68 AAARDLGY-----AVANVGKSHGCLIFKHEKKn-----lYISQDVDGHN-GGRWKMAS--SPENLASKKTRMGTYDANLN 134
gi 511266406  962 SMAKALGF-----QTTNY-KSHGAPVYRQG-Sn-----rYITPDVDSHI-GGVWKMAT--SVINLGSKRTRMGTYDANLK 1026
gi 505246106   48 lVAKELGY-----IKTNYRTKSGAAVFKKGNS-------YITRDIDGHN-GGAWKEAS--SPEKLNKKETRNGTFDINLN 112
gi 643491424  180 QVANELGY-----RDTGY-LSHRVAVFERAARdavkgprYIARDRTSHG-GGVWKGAN--KIEDLASPTRRSGTYDAVLK 250
gi 256363954 1404 DVAKYLGY-----KKTKEMSAGKQPIWVNKKAggg-qpkYITYDRTGHS-GGIFKGASfeKPFQTTKDTGRDGTYDLDVD 1476
gi 505960350  178 EAAKKLGY-----SPTKS-YSHGKKVFKRNKRgn---pmYITPDTDNHS-GGAWKGAS--SIKKLGNKKTRSGTYDANLK 245
gi 289173447  442 DAAKKLGYdqripAQKAPFNSHGQTVFFNKKTk-----tYITPDVDGHNvNNGWKM--------MDKKGKRIGTYDSELN 508
gi 916826665 2155 DIAGYLGY-----TKTNKRSAGGAAIWENKKAgag-qprYVTYDRTGHNkEAVFKGADfrNPFQSTKDSARDGTYGLDV- 2227

                  ....
gi 75432401   222 RIGD 225
gi 635331719  135 RIGD 138
gi 511266406 1027 KIGD 1030
gi 505246106  113 KIGD 116
gi 643491424  251 RIRD 254
gi 256363954 1477 GSGN 1480
gi 505960350  246 RIGD 249
gi 289173447  509 RLKD 512
gi 916826665 2228 ---S 2228
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